Methamphetamine treatment rapidly inhibits serotonin, but not glutamate, transporters in rat brain

Previous studies have demonstrated that multiple methamphetamine (METH) administrations rapidly and reversibly decrease dopamine transporter activity assessed in striatal synaptosomes. A role for reactive oxygen species was suggested by findings that: (1) METH treatment increases the formation of ox...

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Veröffentlicht in:	Brain research 1998-07, Vol.799 (1), p.78-83
Hauptverfasser:	Kokoshka, Jerry M, Metzger, Ryan R, Wilkins, Diana G, Gibb, James W, Hanson, Glen R, Fleckenstein, Annette E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport System X-AG Animals ATP-Binding Cassette Transporters - metabolism Biological and medical sciences Carrier Proteins - antagonists & inhibitors Corpus Striatum - drug effects Corpus Striatum - metabolism Glutamate Glutamic Acid - pharmacokinetics Male Medical sciences Membrane Glycoproteins - antagonists & inhibitors Membrane Transport Proteins Methamphetamine Methamphetamine - pharmacology Nerve Tissue Proteins Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Serotonin Serotonin - pharmacokinetics Serotonin Plasma Membrane Transport Proteins Striatum Synaptosomes - drug effects Synaptosomes - metabolism Time Factors Transporter Xanthine Oxidase - pharmacology
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