Mild acid stress as a differentiation trigger in Trypanosoma brucei

In vitro differentiation of Trypanosoma brucei from the bloodstream to the procyclic form is efficiently induced by the combination of cold shock from 37 to 27°C and the addition of citrate/ cis-aconitate (CCA) to the incubation medium. Here it is reported that exposure of pleomorphic bloodstream tr...

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Veröffentlicht in:	Molecular and biochemical parasitology 1998-06, Vol.93 (2), p.251-262
Hauptverfasser:	Rolin, Sylvie, Hanocq-Quertier, Jacqueline, Paturiaux-Hanocq, Françoise, Nolan, Derek P, Pays, Etienne
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitic Acid - pharmacology Animals Cell signalling Cellular differentiation Citric Acid - pharmacology Culture Media Dihydrolipoamide Dehydrogenase - metabolism Genes, Protozoan Glycosylphosphatidylinositol Diacylglycerol-Lyase Hydrogen-Ion Concentration Membrane Glycoproteins - biosynthesis Mice Mutation pH stress Phosphatidylinositol Diacylglycerol-Lyase Phospholipase C Protozoan Proteins Trypanosoma Trypanosoma brucei brucei - cytology Trypanosoma brucei brucei - genetics Trypanosoma brucei brucei - growth & development Trypanosoma brucei brucei - metabolism Type C Phospholipases - genetics Type C Phospholipases - metabolism Variant Surface Glycoproteins, Trypanosoma - analysis
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