Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging
Aging of the human brain is associated with a decline in dopamine (DA) function, generally interpreted as reflecting DA cell loss. Postitron emission tomography studies revealed that in healthy individuals, the age‐related losses in DA transporters (presynaptic marker) were associated with losses in...
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| Veröffentlicht in: | Annals of neurology 1998-07, Vol.44 (1), p.143-147 |
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| container_title | Annals of neurology |
| container_volume | 44 |
| creator | Volkow, N. D. Wang, G. J. Fowler, J. S. Ding, Y. S. Gur, R. C. Gatley, J. Logan, J. Moberg, P. J. Hitzemann, R. Smith, G. Pappas, N. |
| description | Aging of the human brain is associated with a decline in dopamine (DA) function, generally interpreted as reflecting DA cell loss. Postitron emission tomography studies revealed that in healthy individuals, the age‐related losses in DA transporters (presynaptic marker) were associated with losses in D2 receptors (postsynaptic marker) rather than with increases as is known to occur with DA cell loss. This association was specific for DA synaptic markers, because they were not correlated with striatal metabolism. Furthermore, the association was independent of age, suggesting that a common mechanism regulates the expression of receptors and transporters irrespective of age. |
| doi_str_mv | 10.1002/ana.410440125 |
| format | Article |
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D. ; Wang, G. J. ; Fowler, J. S. ; Ding, Y. S. ; Gur, R. C. ; Gatley, J. ; Logan, J. ; Moberg, P. J. ; Hitzemann, R. ; Smith, G. ; Pappas, N.</creator><creatorcontrib>Volkow, N. D. ; Wang, G. J. ; Fowler, J. S. ; Ding, Y. S. ; Gur, R. C. ; Gatley, J. ; Logan, J. ; Moberg, P. J. ; Hitzemann, R. ; Smith, G. ; Pappas, N.</creatorcontrib><description>Aging of the human brain is associated with a decline in dopamine (DA) function, generally interpreted as reflecting DA cell loss. Postitron emission tomography studies revealed that in healthy individuals, the age‐related losses in DA transporters (presynaptic marker) were associated with losses in D2 receptors (postsynaptic marker) rather than with increases as is known to occur with DA cell loss. This association was specific for DA synaptic markers, because they were not correlated with striatal metabolism. Furthermore, the association was independent of age, suggesting that a common mechanism regulates the expression of receptors and transporters irrespective of age.</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.410440125</identifier><identifier>PMID: 9667606</identifier><identifier>CODEN: ANNED3</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aging - physiology ; Biological and medical sciences ; Biomarkers - analysis ; Carrier Proteins - metabolism ; Corpus Striatum - diagnostic imaging ; Corpus Striatum - metabolism ; Development. Senescence. Regeneration. Transplantation ; Dopamine - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Glucose - metabolism ; Humans ; Male ; Middle Aged ; Receptors, Dopamine D2 - analysis ; Receptors, Presynaptic - physiology ; Tomography, Emission-Computed ; Vertebrates: nervous system and sense organs</subject><ispartof>Annals of neurology, 1998-07, Vol.44 (1), p.143-147</ispartof><rights>Copyright © 1998 American Neurological Association</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4715-23d01cb13294602b1799e456a03e61780366f696030be4fa06a7015889cfc93d3</citedby><cites>FETCH-LOGICAL-c4715-23d01cb13294602b1799e456a03e61780366f696030be4fa06a7015889cfc93d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.410440125$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.410440125$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27933,27934,45583,45584</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2329116$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9667606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Volkow, N. D.</creatorcontrib><creatorcontrib>Wang, G. J.</creatorcontrib><creatorcontrib>Fowler, J. S.</creatorcontrib><creatorcontrib>Ding, Y. S.</creatorcontrib><creatorcontrib>Gur, R. C.</creatorcontrib><creatorcontrib>Gatley, J.</creatorcontrib><creatorcontrib>Logan, J.</creatorcontrib><creatorcontrib>Moberg, P. J.</creatorcontrib><creatorcontrib>Hitzemann, R.</creatorcontrib><creatorcontrib>Smith, G.</creatorcontrib><creatorcontrib>Pappas, N.</creatorcontrib><title>Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>Aging of the human brain is associated with a decline in dopamine (DA) function, generally interpreted as reflecting DA cell loss. Postitron emission tomography studies revealed that in healthy individuals, the age‐related losses in DA transporters (presynaptic marker) were associated with losses in D2 receptors (postsynaptic marker) rather than with increases as is known to occur with DA cell loss. This association was specific for DA synaptic markers, because they were not correlated with striatal metabolism. Furthermore, the association was independent of age, suggesting that a common mechanism regulates the expression of receptors and transporters irrespective of age.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Carrier Proteins - metabolism</subject><subject>Corpus Striatum - diagnostic imaging</subject><subject>Corpus Striatum - metabolism</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Dopamine - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Receptors, Dopamine D2 - analysis</subject><subject>Receptors, Presynaptic - physiology</subject><subject>Tomography, Emission-Computed</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtv1DAURi1EVYaWJUskLxC7lOv4kXg5qkqLVA1VH2Jp3XGcyuA4wZ4RzL_H1UQRK1aWfI-vv-8Q8p7BBQOoP2PEC8FACGC1fEVWTHJWtbXQr8kKuBKVZFy8IW9z_gEAWjE4JadaqUaBWpHNHSYMwQUaxpzp2NMpuXyIOO28pRg7Oo15t1x044SDj44OmH66lKmPNI5pwEDx2cfnc3LSY8ju3XyekacvV4-XN9Xtt-uvl-vbyoqGyarmHTC7ZbzWQkG9ZY3WTkiFwJ1iTVtyq15pBRy2TvQIChtgsm217a3mHT8jn457pzT-2ru8M4PP1oWA0Y37bNpSVWoBBayOoE2lX3K9mZIv4Q-GgXnxZ4o_s_gr_Id58X47uG6hZ2Fl_nGeY7YY-oTR-rxgdWnE2AvWHLHfPrjD__8068363wBzYJ937s_ysug2quGNNN831-bh8a5t5cONued_AY3GlgM</recordid><startdate>199807</startdate><enddate>199807</enddate><creator>Volkow, N. D.</creator><creator>Wang, G. J.</creator><creator>Fowler, J. S.</creator><creator>Ding, Y. S.</creator><creator>Gur, R. C.</creator><creator>Gatley, J.</creator><creator>Logan, J.</creator><creator>Moberg, P. J.</creator><creator>Hitzemann, R.</creator><creator>Smith, G.</creator><creator>Pappas, N.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Willey-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199807</creationdate><title>Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging</title><author>Volkow, N. D. ; Wang, G. J. ; Fowler, J. S. ; Ding, Y. S. ; Gur, R. C. ; Gatley, J. ; Logan, J. ; Moberg, P. J. ; Hitzemann, R. ; Smith, G. ; Pappas, N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4715-23d01cb13294602b1799e456a03e61780366f696030be4fa06a7015889cfc93d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - physiology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Carrier Proteins - metabolism</topic><topic>Corpus Striatum - diagnostic imaging</topic><topic>Corpus Striatum - metabolism</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Dopamine - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Receptors, Dopamine D2 - analysis</topic><topic>Receptors, Presynaptic - physiology</topic><topic>Tomography, Emission-Computed</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Volkow, N. D.</creatorcontrib><creatorcontrib>Wang, G. J.</creatorcontrib><creatorcontrib>Fowler, J. S.</creatorcontrib><creatorcontrib>Ding, Y. S.</creatorcontrib><creatorcontrib>Gur, R. C.</creatorcontrib><creatorcontrib>Gatley, J.</creatorcontrib><creatorcontrib>Logan, J.</creatorcontrib><creatorcontrib>Moberg, P. J.</creatorcontrib><creatorcontrib>Hitzemann, R.</creatorcontrib><creatorcontrib>Smith, G.</creatorcontrib><creatorcontrib>Pappas, N.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Volkow, N. D.</au><au>Wang, G. J.</au><au>Fowler, J. S.</au><au>Ding, Y. S.</au><au>Gur, R. C.</au><au>Gatley, J.</au><au>Logan, J.</au><au>Moberg, P. J.</au><au>Hitzemann, R.</au><au>Smith, G.</au><au>Pappas, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>1998-07</date><risdate>1998</risdate><volume>44</volume><issue>1</issue><spage>143</spage><epage>147</epage><pages>143-147</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>Aging of the human brain is associated with a decline in dopamine (DA) function, generally interpreted as reflecting DA cell loss. Postitron emission tomography studies revealed that in healthy individuals, the age‐related losses in DA transporters (presynaptic marker) were associated with losses in D2 receptors (postsynaptic marker) rather than with increases as is known to occur with DA cell loss. 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| subjects | Adult Aged Aged, 80 and over Aging - physiology Biological and medical sciences Biomarkers - analysis Carrier Proteins - metabolism Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism Development. Senescence. Regeneration. Transplantation Dopamine - physiology Female Fundamental and applied biological sciences. Psychology Glucose - metabolism Humans Male Middle Aged Receptors, Dopamine D2 - analysis Receptors, Presynaptic - physiology Tomography, Emission-Computed Vertebrates: nervous system and sense organs |
| title | Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging |
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