Augmentation of the inhibitory effect of FK480, a CCK-A receptor antagonist, on pancreatic exocrine secretion by achlorhydria
The effect of intraluminal acid and cholecystokinin (CCK) receptor blockade on the pancreatic secretory response was examined in rats. Blockade of gastric acid secretion by YM022 (CCK-B receptor antagonist) or famotidine (histamine-2 receptor antagonist) resulted in a significant suppression of case...
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| Veröffentlicht in: | Pancreas 1998-07, Vol.17 (1), p.57-64 |
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| creator | KUNO, M SOGABE, H ITO, H MATSUO, T SATOH, Y MOTOYAMA, Y TANAKA, H |
| description | The effect of intraluminal acid and cholecystokinin (CCK) receptor blockade on the pancreatic secretory response was examined in rats. Blockade of gastric acid secretion by YM022 (CCK-B receptor antagonist) or famotidine (histamine-2 receptor antagonist) resulted in a significant suppression of casein-stimulated pancreatic exocrine secretion as determined by juice volume and amylase secretion. Ligation of the gastric pylorus, which leads to complete prevention of gastric acid from entering the duodenum, also suppressed pancreatic exocrine secretion. FK480 (CCK-A receptor antagonist) inhibited pancreatic exocrine secretion dose dependently at doses of 0.01-1.0 mg/kg. When submaximal doses of FK480 and YM022 were treated concomitantly, pancreatic exocrine secretion was inhibited more profoundly than when treated solely. Hydrochloric acid (HCl; 0.05 N), injected into the duodenum, stimulated pancreatic exocrine secretion to a level comparable to that exhibited by intraduodenal casein. This effect of HCl was inhibited by FK480 (1.0 mg/kg) but not by YM022 (1.0 mg/kg). These findings suggest that inhibition of gastric acid secretion leads to the suppression of pancreatic exocrine secretion through mechanisms mediated by CCK-A receptors. |
| doi_str_mv | 10.1097/00006676-199807000-00007 |
| format | Article |
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Blockade of gastric acid secretion by YM022 (CCK-B receptor antagonist) or famotidine (histamine-2 receptor antagonist) resulted in a significant suppression of casein-stimulated pancreatic exocrine secretion as determined by juice volume and amylase secretion. Ligation of the gastric pylorus, which leads to complete prevention of gastric acid from entering the duodenum, also suppressed pancreatic exocrine secretion. FK480 (CCK-A receptor antagonist) inhibited pancreatic exocrine secretion dose dependently at doses of 0.01-1.0 mg/kg. When submaximal doses of FK480 and YM022 were treated concomitantly, pancreatic exocrine secretion was inhibited more profoundly than when treated solely. Hydrochloric acid (HCl; 0.05 N), injected into the duodenum, stimulated pancreatic exocrine secretion to a level comparable to that exhibited by intraduodenal casein. This effect of HCl was inhibited by FK480 (1.0 mg/kg) but not by YM022 (1.0 mg/kg). These findings suggest that inhibition of gastric acid secretion leads to the suppression of pancreatic exocrine secretion through mechanisms mediated by CCK-A receptors.</description><identifier>ISSN: 0885-3177</identifier><identifier>EISSN: 1536-4828</identifier><identifier>DOI: 10.1097/00006676-199807000-00007</identifier><identifier>PMID: 9667521</identifier><identifier>CODEN: PANCE4</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Achlorhydria - complications ; Amylases - drug effects ; Amylases - metabolism ; Animals ; Benzodiazepines - pharmacology ; Benzodiazepinones - pharmacology ; Biological and medical sciences ; Caseins - pharmacology ; Digestive system ; Dose-Response Relationship, Drug ; Duodenum - drug effects ; Famotidine - pharmacology ; Gastric Acid - metabolism ; Histamine H2 Antagonists - pharmacology ; Hormone Antagonists - pharmacology ; Hydrochloric Acid - pharmacology ; Indoles - pharmacology ; Male ; Medical sciences ; Pancreas - drug effects ; Pancreas - metabolism ; Pharmacology. Drug treatments ; Rats ; Rats, Wistar ; Receptor, Cholecystokinin A ; Receptors, Cholecystokinin - antagonists & inhibitors</subject><ispartof>Pancreas, 1998-07, Vol.17 (1), p.57-64</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-820e8653845d6afa0f498c942561eafc8d123574996fcf953bd42acfebe0dee33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>310,311,315,781,785,790,791,23934,23935,25144,27928,27929</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2323470$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9667521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KUNO, M</creatorcontrib><creatorcontrib>SOGABE, H</creatorcontrib><creatorcontrib>ITO, H</creatorcontrib><creatorcontrib>MATSUO, T</creatorcontrib><creatorcontrib>SATOH, Y</creatorcontrib><creatorcontrib>MOTOYAMA, Y</creatorcontrib><creatorcontrib>TANAKA, H</creatorcontrib><title>Augmentation of the inhibitory effect of FK480, a CCK-A receptor antagonist, on pancreatic exocrine secretion by achlorhydria</title><title>Pancreas</title><addtitle>Pancreas</addtitle><description>The effect of intraluminal acid and cholecystokinin (CCK) receptor blockade on the pancreatic secretory response was examined in rats. Blockade of gastric acid secretion by YM022 (CCK-B receptor antagonist) or famotidine (histamine-2 receptor antagonist) resulted in a significant suppression of casein-stimulated pancreatic exocrine secretion as determined by juice volume and amylase secretion. Ligation of the gastric pylorus, which leads to complete prevention of gastric acid from entering the duodenum, also suppressed pancreatic exocrine secretion. FK480 (CCK-A receptor antagonist) inhibited pancreatic exocrine secretion dose dependently at doses of 0.01-1.0 mg/kg. When submaximal doses of FK480 and YM022 were treated concomitantly, pancreatic exocrine secretion was inhibited more profoundly than when treated solely. Hydrochloric acid (HCl; 0.05 N), injected into the duodenum, stimulated pancreatic exocrine secretion to a level comparable to that exhibited by intraduodenal casein. This effect of HCl was inhibited by FK480 (1.0 mg/kg) but not by YM022 (1.0 mg/kg). These findings suggest that inhibition of gastric acid secretion leads to the suppression of pancreatic exocrine secretion through mechanisms mediated by CCK-A receptors.</description><subject>Achlorhydria - complications</subject><subject>Amylases - drug effects</subject><subject>Amylases - metabolism</subject><subject>Animals</subject><subject>Benzodiazepines - pharmacology</subject><subject>Benzodiazepinones - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Caseins - pharmacology</subject><subject>Digestive system</subject><subject>Dose-Response Relationship, Drug</subject><subject>Duodenum - drug effects</subject><subject>Famotidine - pharmacology</subject><subject>Gastric Acid - metabolism</subject><subject>Histamine H2 Antagonists - pharmacology</subject><subject>Hormone Antagonists - pharmacology</subject><subject>Hydrochloric Acid - pharmacology</subject><subject>Indoles - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pancreas - drug effects</subject><subject>Pancreas - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptor, Cholecystokinin A</subject><subject>Receptors, Cholecystokinin - antagonists & inhibitors</subject><issn>0885-3177</issn><issn>1536-4828</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtKAzEUhoMoWi-PIGQhrhxNJvdlKd5QcKPrIZM5sZHppCZTsAvf3VRrsznkv5wDH0KYkmtKjLoh5UmpZEWN0USVX7WR1B6aUMFkxXWt99GEaC0qRpU6Qsc5fxBCFRPmEB2aUhY1naDv6ep9AcNoxxAHHD0e54DDMA9tGGNaY_Ae3Lgx7p64JlfY4tnsqZriBA6WJYJtKb_HIeTxCpcVSzu4BGWdw_AVXQoD4AxF-j3QrrF18z6m-bpLwZ6iA2_7DGfbeYLe7m5fZw_V88v942z6XDkm9VjpmoCWgmkuOmm9JZ4b7QyvhaRgvdMdrZlQ3BjpnTeCtR2vrfPQAukAGDtBl397lyl-riCPzSJkB31vB4ir3OjCTnCqS1D_BV2KOSfwzTKFhU3rhpJmQ775J9_syP9KqlTPtzdW7QK6XXGLuvgXW99mZ3ufCqiQd7Ga1Ywrwn4AOGmMFA</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>KUNO, M</creator><creator>SOGABE, H</creator><creator>ITO, H</creator><creator>MATSUO, T</creator><creator>SATOH, Y</creator><creator>MOTOYAMA, Y</creator><creator>TANAKA, H</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980701</creationdate><title>Augmentation of the inhibitory effect of FK480, a CCK-A receptor antagonist, on pancreatic exocrine secretion by achlorhydria</title><author>KUNO, M ; SOGABE, H ; ITO, H ; MATSUO, T ; SATOH, Y ; MOTOYAMA, Y ; TANAKA, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-820e8653845d6afa0f498c942561eafc8d123574996fcf953bd42acfebe0dee33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Achlorhydria - complications</topic><topic>Amylases - drug effects</topic><topic>Amylases - metabolism</topic><topic>Animals</topic><topic>Benzodiazepines - pharmacology</topic><topic>Benzodiazepinones - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Caseins - pharmacology</topic><topic>Digestive system</topic><topic>Dose-Response Relationship, Drug</topic><topic>Duodenum - drug effects</topic><topic>Famotidine - pharmacology</topic><topic>Gastric Acid - metabolism</topic><topic>Histamine H2 Antagonists - pharmacology</topic><topic>Hormone Antagonists - pharmacology</topic><topic>Hydrochloric Acid - pharmacology</topic><topic>Indoles - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pancreas - drug effects</topic><topic>Pancreas - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptor, Cholecystokinin A</topic><topic>Receptors, Cholecystokinin - antagonists & inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KUNO, M</creatorcontrib><creatorcontrib>SOGABE, H</creatorcontrib><creatorcontrib>ITO, H</creatorcontrib><creatorcontrib>MATSUO, T</creatorcontrib><creatorcontrib>SATOH, Y</creatorcontrib><creatorcontrib>MOTOYAMA, Y</creatorcontrib><creatorcontrib>TANAKA, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pancreas</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KUNO, M</au><au>SOGABE, H</au><au>ITO, H</au><au>MATSUO, T</au><au>SATOH, Y</au><au>MOTOYAMA, Y</au><au>TANAKA, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Augmentation of the inhibitory effect of FK480, a CCK-A receptor antagonist, on pancreatic exocrine secretion by achlorhydria</atitle><jtitle>Pancreas</jtitle><addtitle>Pancreas</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>17</volume><issue>1</issue><spage>57</spage><epage>64</epage><pages>57-64</pages><issn>0885-3177</issn><eissn>1536-4828</eissn><coden>PANCE4</coden><abstract>The effect of intraluminal acid and cholecystokinin (CCK) receptor blockade on the pancreatic secretory response was examined in rats. Blockade of gastric acid secretion by YM022 (CCK-B receptor antagonist) or famotidine (histamine-2 receptor antagonist) resulted in a significant suppression of casein-stimulated pancreatic exocrine secretion as determined by juice volume and amylase secretion. Ligation of the gastric pylorus, which leads to complete prevention of gastric acid from entering the duodenum, also suppressed pancreatic exocrine secretion. FK480 (CCK-A receptor antagonist) inhibited pancreatic exocrine secretion dose dependently at doses of 0.01-1.0 mg/kg. When submaximal doses of FK480 and YM022 were treated concomitantly, pancreatic exocrine secretion was inhibited more profoundly than when treated solely. Hydrochloric acid (HCl; 0.05 N), injected into the duodenum, stimulated pancreatic exocrine secretion to a level comparable to that exhibited by intraduodenal casein. This effect of HCl was inhibited by FK480 (1.0 mg/kg) but not by YM022 (1.0 mg/kg). These findings suggest that inhibition of gastric acid secretion leads to the suppression of pancreatic exocrine secretion through mechanisms mediated by CCK-A receptors.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>9667521</pmid><doi>10.1097/00006676-199807000-00007</doi><tpages>8</tpages></addata></record> |
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| subjects | Achlorhydria - complications Amylases - drug effects Amylases - metabolism Animals Benzodiazepines - pharmacology Benzodiazepinones - pharmacology Biological and medical sciences Caseins - pharmacology Digestive system Dose-Response Relationship, Drug Duodenum - drug effects Famotidine - pharmacology Gastric Acid - metabolism Histamine H2 Antagonists - pharmacology Hormone Antagonists - pharmacology Hydrochloric Acid - pharmacology Indoles - pharmacology Male Medical sciences Pancreas - drug effects Pancreas - metabolism Pharmacology. Drug treatments Rats Rats, Wistar Receptor, Cholecystokinin A Receptors, Cholecystokinin - antagonists & inhibitors |
| title | Augmentation of the inhibitory effect of FK480, a CCK-A receptor antagonist, on pancreatic exocrine secretion by achlorhydria |
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