Differential effect of membrane depolarization on levels of tyrosine hydroxylase and dopamine β-hydroxylase mRNAs in PC12 pheochromocytoma cells

Membrane depolarization has been widely used to elucidate the response of the nervous system to prolonged neuronal activity or stress. We studied the effect of treating PC12 cells with membrane depolarizing stimuli, 50 mM KCl, or 150 μM veratridine, and the subsequent changes in the mRNA levels of t...

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Veröffentlicht in:	Brain research. Molecular brain research. 1990-07, Vol.8 (2), p.121-127
Hauptverfasser:	Kilbourne, Edward J., Sabban, Esther L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Gland Neoplasms - enzymology Adrenal Gland Neoplasms - pathology Animals Calcimycin - pharmacology Calcium - physiology Calcium channel Calcium Channel Blockers - pharmacology Calmodulin - antagonists & inhibitors Catecholamine Dopamine beta-Hydroxylase - biosynthesis Dopamine beta-Hydroxylase - genetics Dopamine β-hydroxylase Enzyme Induction - drug effects Membrane depolarization Membrane Potentials - drug effects Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics PC12 cell Pheochromocytoma - enzymology Pheochromocytoma - pathology Potassium Chloride - pharmacology Rats RNA, Messenger - biosynthesis RNA, Neoplasm - biosynthesis Second Messenger Systems - drug effects Tumor Cells, Cultured - enzymology Tyrosine 3-Monooxygenase - biosynthesis Tyrosine 3-Monooxygenase - genetics Tyrosine hydroxylase Veratridine - pharmacology
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