Subclinical peripheral nerve involvement in patients with rheumatoid arthritis
Objective Clinical involvement of the peripheral nervous system is uncommon in rheumatoid arthritis (RA); the most common disorders are multiple mononeuritis, sensorimotor neuropathy, and entrapment neuropathy. This study was undertaken to investigate the occurrence of electrophysiologically evident...
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| Veröffentlicht in: | Arthritis and rheumatism 1998-07, Vol.41 (7), p.1196-1202 |
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| creator | Lanzillo, B. Pappone, N. Crisci, C. Di Girolamo, C. Massini, R. Caruso, G. |
| description | Objective
Clinical involvement of the peripheral nervous system is uncommon in rheumatoid arthritis (RA); the most common disorders are multiple mononeuritis, sensorimotor neuropathy, and entrapment neuropathy. This study was undertaken to investigate the occurrence of electrophysiologically evident peripheral nerve involvement in RA patients without a clinical history of peripheral nerve involvement.
Methods
Forty RA patients were examined neurologically and electrophysiologically, and sural nerve biopsies were performed in 4.
Results
No patient reported symptoms or signs of peripheral nerve involvement. Twenty‐six patients (65%) exhibited electrophysiologic findings consistent with a sensorimotor neuropathy (in 2 of them a carpal tunnel syndrome was also present), while 3 patients showed isolated carpal tunnel syndrome. There was a moderate loss of myelinated fibers in 3 of the 4 nerve biopsy samples, and all showed an increased number of endo‐ and perineurial vessels and some signs of axonal degeneration.
Conclusion
Patients with RA may have electrophysiologic and histologic findings of peripheral nerve damage, even in the absence of clinical evidence of peripheral nerve involvement. |
| doi_str_mv | 10.1002/1529-0131(199807)41:7<1196::AID-ART8>3.0.CO;2-R |
| format | Article |
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Clinical involvement of the peripheral nervous system is uncommon in rheumatoid arthritis (RA); the most common disorders are multiple mononeuritis, sensorimotor neuropathy, and entrapment neuropathy. This study was undertaken to investigate the occurrence of electrophysiologically evident peripheral nerve involvement in RA patients without a clinical history of peripheral nerve involvement.
Methods
Forty RA patients were examined neurologically and electrophysiologically, and sural nerve biopsies were performed in 4.
Results
No patient reported symptoms or signs of peripheral nerve involvement. Twenty‐six patients (65%) exhibited electrophysiologic findings consistent with a sensorimotor neuropathy (in 2 of them a carpal tunnel syndrome was also present), while 3 patients showed isolated carpal tunnel syndrome. There was a moderate loss of myelinated fibers in 3 of the 4 nerve biopsy samples, and all showed an increased number of endo‐ and perineurial vessels and some signs of axonal degeneration.
Conclusion
Patients with RA may have electrophysiologic and histologic findings of peripheral nerve damage, even in the absence of clinical evidence of peripheral nerve involvement.</description><identifier>ISSN: 0004-3591</identifier><identifier>EISSN: 1529-0131</identifier><identifier>DOI: 10.1002/1529-0131(199807)41:7<1196::AID-ART8>3.0.CO;2-R</identifier><identifier>PMID: 9663475</identifier><identifier>CODEN: ARHEAW</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Arthritis, Rheumatoid - pathology ; Arthritis, Rheumatoid - physiopathology ; Biological and medical sciences ; Diseases of the osteoarticular system ; Electrophysiology ; Female ; Humans ; Male ; Median Nerve - physiopathology ; Medical sciences ; Middle Aged ; Peripheral Nerves - pathology ; Peripheral Nerves - physiopathology ; Reflex, Stretch ; Sural Nerve - pathology ; Tibial Nerve - physiopathology ; Tumors of striated muscle and skeleton</subject><ispartof>Arthritis and rheumatism, 1998-07, Vol.41 (7), p.1196-1202</ispartof><rights>Copyright © 1998 by the American College of Rheumatology</rights><rights>1998 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4838-f4701cce9d30972a2baf4b3fee7233739a9756b270e67d8793654acbc645b663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F1529-0131%28199807%2941%3A7%3C1196%3A%3AAID-ART8%3E3.0.CO%3B2-R$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F1529-0131%28199807%2941%3A7%3C1196%3A%3AAID-ART8%3E3.0.CO%3B2-R$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2313129$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9663475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lanzillo, B.</creatorcontrib><creatorcontrib>Pappone, N.</creatorcontrib><creatorcontrib>Crisci, C.</creatorcontrib><creatorcontrib>Di Girolamo, C.</creatorcontrib><creatorcontrib>Massini, R.</creatorcontrib><creatorcontrib>Caruso, G.</creatorcontrib><title>Subclinical peripheral nerve involvement in patients with rheumatoid arthritis</title><title>Arthritis and rheumatism</title><addtitle>Arthritis Rheum</addtitle><description>Objective
Clinical involvement of the peripheral nervous system is uncommon in rheumatoid arthritis (RA); the most common disorders are multiple mononeuritis, sensorimotor neuropathy, and entrapment neuropathy. This study was undertaken to investigate the occurrence of electrophysiologically evident peripheral nerve involvement in RA patients without a clinical history of peripheral nerve involvement.
Methods
Forty RA patients were examined neurologically and electrophysiologically, and sural nerve biopsies were performed in 4.
Results
No patient reported symptoms or signs of peripheral nerve involvement. Twenty‐six patients (65%) exhibited electrophysiologic findings consistent with a sensorimotor neuropathy (in 2 of them a carpal tunnel syndrome was also present), while 3 patients showed isolated carpal tunnel syndrome. There was a moderate loss of myelinated fibers in 3 of the 4 nerve biopsy samples, and all showed an increased number of endo‐ and perineurial vessels and some signs of axonal degeneration.
Conclusion
Patients with RA may have electrophysiologic and histologic findings of peripheral nerve damage, even in the absence of clinical evidence of peripheral nerve involvement.</description><subject>Adult</subject><subject>Aged</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Arthritis, Rheumatoid - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Diseases of the osteoarticular system</subject><subject>Electrophysiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Median Nerve - physiopathology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Peripheral Nerves - pathology</subject><subject>Peripheral Nerves - physiopathology</subject><subject>Reflex, Stretch</subject><subject>Sural Nerve - pathology</subject><subject>Tibial Nerve - physiopathology</subject><subject>Tumors of striated muscle and skeleton</subject><issn>0004-3591</issn><issn>1529-0131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUV2LEzEUDeKy1tWfIMyDyPowNcmdTCZ1EUp1dWGxUvt-yaQZGpkvk5ku--_NbEufBPEp93JPzj33HEIko3NGKf_ABFcpZcCumVIFle8ztpA3jKl8sVjefU6Xm23xCeZ0vlp_5OnmGZmdfzwnM0pploJQ7AV5GcKv2HIQcEkuVZ5DJsWMfP85lqZ2rTO6TnrrXb-3Ppat9QebuPbQ1Qfb2HaIddLrwcUyJA9u2Cd-b8dGD53bJdoPe-8GF16Ri0rXwb4-vVdke_tlu_qW3q-_3q2W96nJCijSKpOUGWPVDqiSXPNSV1kJlbWSA0hQWkmRl1xSm8tdIRXkItOmNHkmyij9irw70va--z3aMGDjgrF1rVvbjQGLeCkUXP0TyHIhgBYT4_oINL4LwdsKe-8a7R-RUZySwMlXnHzFYxKYMZQ4JYEYk8ApCQSkuFojx01kfHNaPZaN3Z35TtbH-dvTXIdofuV1a1w4wzjEVU8X_DjCHlxtH_9H1V9EPfXwB57crZw</recordid><startdate>199807</startdate><enddate>199807</enddate><creator>Lanzillo, B.</creator><creator>Pappone, N.</creator><creator>Crisci, C.</creator><creator>Di Girolamo, C.</creator><creator>Massini, R.</creator><creator>Caruso, G.</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199807</creationdate><title>Subclinical peripheral nerve involvement in patients with rheumatoid arthritis</title><author>Lanzillo, B. ; Pappone, N. ; Crisci, C. ; Di Girolamo, C. ; Massini, R. ; Caruso, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4838-f4701cce9d30972a2baf4b3fee7233739a9756b270e67d8793654acbc645b663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>Arthritis, Rheumatoid - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Diseases of the osteoarticular system</topic><topic>Electrophysiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Median Nerve - physiopathology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Peripheral Nerves - pathology</topic><topic>Peripheral Nerves - physiopathology</topic><topic>Reflex, Stretch</topic><topic>Sural Nerve - pathology</topic><topic>Tibial Nerve - physiopathology</topic><topic>Tumors of striated muscle and skeleton</topic><toplevel>online_resources</toplevel><creatorcontrib>Lanzillo, B.</creatorcontrib><creatorcontrib>Pappone, N.</creatorcontrib><creatorcontrib>Crisci, C.</creatorcontrib><creatorcontrib>Di Girolamo, C.</creatorcontrib><creatorcontrib>Massini, R.</creatorcontrib><creatorcontrib>Caruso, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lanzillo, B.</au><au>Pappone, N.</au><au>Crisci, C.</au><au>Di Girolamo, C.</au><au>Massini, R.</au><au>Caruso, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subclinical peripheral nerve involvement in patients with rheumatoid arthritis</atitle><jtitle>Arthritis and rheumatism</jtitle><addtitle>Arthritis Rheum</addtitle><date>1998-07</date><risdate>1998</risdate><volume>41</volume><issue>7</issue><spage>1196</spage><epage>1202</epage><pages>1196-1202</pages><issn>0004-3591</issn><eissn>1529-0131</eissn><coden>ARHEAW</coden><abstract>Objective
Clinical involvement of the peripheral nervous system is uncommon in rheumatoid arthritis (RA); the most common disorders are multiple mononeuritis, sensorimotor neuropathy, and entrapment neuropathy. This study was undertaken to investigate the occurrence of electrophysiologically evident peripheral nerve involvement in RA patients without a clinical history of peripheral nerve involvement.
Methods
Forty RA patients were examined neurologically and electrophysiologically, and sural nerve biopsies were performed in 4.
Results
No patient reported symptoms or signs of peripheral nerve involvement. Twenty‐six patients (65%) exhibited electrophysiologic findings consistent with a sensorimotor neuropathy (in 2 of them a carpal tunnel syndrome was also present), while 3 patients showed isolated carpal tunnel syndrome. There was a moderate loss of myelinated fibers in 3 of the 4 nerve biopsy samples, and all showed an increased number of endo‐ and perineurial vessels and some signs of axonal degeneration.
Conclusion
Patients with RA may have electrophysiologic and histologic findings of peripheral nerve damage, even in the absence of clinical evidence of peripheral nerve involvement.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>9663475</pmid><doi>10.1002/1529-0131(199807)41:7<1196::AID-ART8>3.0.CO;2-R</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Arthritis, Rheumatoid - pathology Arthritis, Rheumatoid - physiopathology Biological and medical sciences Diseases of the osteoarticular system Electrophysiology Female Humans Male Median Nerve - physiopathology Medical sciences Middle Aged Peripheral Nerves - pathology Peripheral Nerves - physiopathology Reflex, Stretch Sural Nerve - pathology Tibial Nerve - physiopathology Tumors of striated muscle and skeleton |
| title | Subclinical peripheral nerve involvement in patients with rheumatoid arthritis |
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