In vitro assessment of the effects of granulocyte-macrophage colony-stimulating factor on primary human tumors and derived lines
One hundred eighty-nine human tumor specimens were tested in a human tumor cloning assay to determine their growth response to human recombinant granulocyte-macrophage colony-stimulating factor. Of these samples 48 were evaluable for response. Growth stimulation to greater than 150% of controls was...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1990-10, Vol.50 (19), p.6264-6267 |
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| creator | Foulke, R S Marshall, M H Trotta, P P Von Hoff, D D |
| description | One hundred eighty-nine human tumor specimens were tested in a human tumor cloning assay to determine their growth response to human recombinant granulocyte-macrophage colony-stimulating factor. Of these samples 48 were evaluable for response. Growth stimulation to greater than 150% of controls was noted in 1 of 12 lung cancers (8%) and 1 of 14 breast cancers (7%) but in no other instances for an overall rate of 2 of 48 (4.2%). A dose-response effect was not seen with each of the two stimulated samples responding only at the two lowest concentrations tested. In addition, 7 cell lines derived from human tumors were tested using a metabolic CO2 production assay without evidence of growth stimulation. Samples of normal bone marrow displayed the usual dose-dependent stimulation whether grown in agar or assayed metabolically. We conclude that human recombinant granulocyte-macrophage colony-stimulating factor has minimal effect on the growth of the solid tumors tested and that clinical trials to reduce chemotherapy-associated myelo-suppression may proceed without undue concern for enhancement of tumor growth. |
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Of these samples 48 were evaluable for response. Growth stimulation to greater than 150% of controls was noted in 1 of 12 lung cancers (8%) and 1 of 14 breast cancers (7%) but in no other instances for an overall rate of 2 of 48 (4.2%). A dose-response effect was not seen with each of the two stimulated samples responding only at the two lowest concentrations tested. In addition, 7 cell lines derived from human tumors were tested using a metabolic CO2 production assay without evidence of growth stimulation. Samples of normal bone marrow displayed the usual dose-dependent stimulation whether grown in agar or assayed metabolically. We conclude that human recombinant granulocyte-macrophage colony-stimulating factor has minimal effect on the growth of the solid tumors tested and that clinical trials to reduce chemotherapy-associated myelo-suppression may proceed without undue concern for enhancement of tumor growth.</description><identifier>ISSN: 0008-5472</identifier><identifier>PMID: 2205378</identifier><language>eng</language><publisher>United States</publisher><subject>Adenocarcinoma - pathology ; Breast Neoplasms - pathology ; Carcinoma, Squamous Cell - pathology ; Colonic Neoplasms - pathology ; Colony-Forming Units Assay ; Colony-Stimulating Factors - pharmacology ; Granulocyte-Macrophage Colony-Stimulating Factor ; Growth Substances - pharmacology ; Humans ; Lung Neoplasms - pathology ; Recombinant Proteins - pharmacology ; Tumor Cells, Cultured ; Tumor Stem Cell Assay</subject><ispartof>Cancer research (Chicago, Ill.), 1990-10, Vol.50 (19), p.6264-6267</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2205378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Foulke, R S</creatorcontrib><creatorcontrib>Marshall, M H</creatorcontrib><creatorcontrib>Trotta, P P</creatorcontrib><creatorcontrib>Von Hoff, D D</creatorcontrib><title>In vitro assessment of the effects of granulocyte-macrophage colony-stimulating factor on primary human tumors and derived lines</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>One hundred eighty-nine human tumor specimens were tested in a human tumor cloning assay to determine their growth response to human recombinant granulocyte-macrophage colony-stimulating factor. Of these samples 48 were evaluable for response. Growth stimulation to greater than 150% of controls was noted in 1 of 12 lung cancers (8%) and 1 of 14 breast cancers (7%) but in no other instances for an overall rate of 2 of 48 (4.2%). A dose-response effect was not seen with each of the two stimulated samples responding only at the two lowest concentrations tested. In addition, 7 cell lines derived from human tumors were tested using a metabolic CO2 production assay without evidence of growth stimulation. Samples of normal bone marrow displayed the usual dose-dependent stimulation whether grown in agar or assayed metabolically. We conclude that human recombinant granulocyte-macrophage colony-stimulating factor has minimal effect on the growth of the solid tumors tested and that clinical trials to reduce chemotherapy-associated myelo-suppression may proceed without undue concern for enhancement of tumor growth.</description><subject>Adenocarcinoma - pathology</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Colonic Neoplasms - pathology</subject><subject>Colony-Forming Units Assay</subject><subject>Colony-Stimulating Factors - pharmacology</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor</subject><subject>Growth Substances - pharmacology</subject><subject>Humans</subject><subject>Lung Neoplasms - pathology</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Tumor Cells, Cultured</subject><subject>Tumor Stem Cell Assay</subject><issn>0008-5472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkE1LxDAYhHNQ1nX1Jwg5eSu0TdO0R1n8WFjwoufyNn3TRppkzcfC3vzpVuxpGHhmYOaKbPM8bzJeifKG3IbwtVhe5HxDNmWZcyaaLfk5WHrW0TsKIWAIBm2kTtE4IUWlUMbwZ0cPNs1OXiJmBqR3pwlGpNLNzl6yELVJM0RtR6pARueps_TktQF_oVMyYGlMxvlAwQ50QK_PONBZWwx35FrBHPB-1R35fHn-2L9lx_fXw_7pmE0F5zFrC1EVKFpeCtnWTc16WUErS9GDyhGhErzoFROyZsCLphWNkENd1XwJKCZLtiOP_70n774ThtgZHSTOM1h0KXTNcg7jNV_AhxVMvcGhW2d062XsF8qbaUE</recordid><startdate>19901001</startdate><enddate>19901001</enddate><creator>Foulke, R S</creator><creator>Marshall, M H</creator><creator>Trotta, P P</creator><creator>Von Hoff, D D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19901001</creationdate><title>In vitro assessment of the effects of granulocyte-macrophage colony-stimulating factor on primary human tumors and derived lines</title><author>Foulke, R S ; Marshall, M H ; Trotta, P P ; Von Hoff, D D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h155t-91741e79527c96863bc4a9c27baf0eea4751bf37c63a5189787cd6465527f3c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adenocarcinoma - pathology</topic><topic>Breast Neoplasms - pathology</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Colonic Neoplasms - pathology</topic><topic>Colony-Forming Units Assay</topic><topic>Colony-Stimulating Factors - pharmacology</topic><topic>Granulocyte-Macrophage Colony-Stimulating Factor</topic><topic>Growth Substances - pharmacology</topic><topic>Humans</topic><topic>Lung Neoplasms - pathology</topic><topic>Recombinant Proteins - pharmacology</topic><topic>Tumor Cells, Cultured</topic><topic>Tumor Stem Cell Assay</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Foulke, R S</creatorcontrib><creatorcontrib>Marshall, M H</creatorcontrib><creatorcontrib>Trotta, P P</creatorcontrib><creatorcontrib>Von Hoff, D D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Foulke, R S</au><au>Marshall, M H</au><au>Trotta, P P</au><au>Von Hoff, D D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro assessment of the effects of granulocyte-macrophage colony-stimulating factor on primary human tumors and derived lines</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>1990-10-01</date><risdate>1990</risdate><volume>50</volume><issue>19</issue><spage>6264</spage><epage>6267</epage><pages>6264-6267</pages><issn>0008-5472</issn><abstract>One hundred eighty-nine human tumor specimens were tested in a human tumor cloning assay to determine their growth response to human recombinant granulocyte-macrophage colony-stimulating factor. Of these samples 48 were evaluable for response. Growth stimulation to greater than 150% of controls was noted in 1 of 12 lung cancers (8%) and 1 of 14 breast cancers (7%) but in no other instances for an overall rate of 2 of 48 (4.2%). A dose-response effect was not seen with each of the two stimulated samples responding only at the two lowest concentrations tested. In addition, 7 cell lines derived from human tumors were tested using a metabolic CO2 production assay without evidence of growth stimulation. Samples of normal bone marrow displayed the usual dose-dependent stimulation whether grown in agar or assayed metabolically. We conclude that human recombinant granulocyte-macrophage colony-stimulating factor has minimal effect on the growth of the solid tumors tested and that clinical trials to reduce chemotherapy-associated myelo-suppression may proceed without undue concern for enhancement of tumor growth.</abstract><cop>United States</cop><pmid>2205378</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Cancer research (Chicago, Ill.), 1990-10, Vol.50 (19), p.6264-6267 |
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| language | eng |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adenocarcinoma - pathology Breast Neoplasms - pathology Carcinoma, Squamous Cell - pathology Colonic Neoplasms - pathology Colony-Forming Units Assay Colony-Stimulating Factors - pharmacology Granulocyte-Macrophage Colony-Stimulating Factor Growth Substances - pharmacology Humans Lung Neoplasms - pathology Recombinant Proteins - pharmacology Tumor Cells, Cultured Tumor Stem Cell Assay |
| title | In vitro assessment of the effects of granulocyte-macrophage colony-stimulating factor on primary human tumors and derived lines |
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