Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle
Tubulin is the biochemical target for several clinically used anticancer drugs, including paclitaxel and the vinca alkaloids vincristine and vinblastine. This review describes both the natural and synthetic agents which are known to interact with tubulin. Syntheses of the more complex agents are ref...
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| Veröffentlicht in: | Medicinal research reviews 1998-07, Vol.18 (4), p.259-296 |
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| creator | Jordan, Allan Hadfield, John A. Lawrence, Nicholas J. McGown, Alan T. |
| description | Tubulin is the biochemical target for several clinically used anticancer drugs, including paclitaxel and the vinca alkaloids vincristine and vinblastine. This review describes both the natural and synthetic agents which are known to interact with tubulin. Syntheses of the more complex agents are referenced and the potential clinical use of the compounds is discussed. This review describes the biochemistry of tubulin, microtubules, and the mitotic spindle. The agents are discussed in relation to the type of binding site on the protein with which they interact. These are the colchicine, vinca alkaloid, rhizoxin/maytansine, and tubulin sulfhydryl binding sites. Also included are the agents which either bind at other sites or unknown sites on tubulin. The literature is reviewed up to October 1997. © 1998 John Wiley & Sons, Inc., Med Res Rev, 18, No. 4, 259–296, 1998. |
| doi_str_mv | 10.1002/(SICI)1098-1128(199807)18:4<259::AID-MED3>3.0.CO;2-U |
| format | Article |
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Res. Rev</addtitle><description>Tubulin is the biochemical target for several clinically used anticancer drugs, including paclitaxel and the vinca alkaloids vincristine and vinblastine. This review describes both the natural and synthetic agents which are known to interact with tubulin. Syntheses of the more complex agents are referenced and the potential clinical use of the compounds is discussed. This review describes the biochemistry of tubulin, microtubules, and the mitotic spindle. The agents are discussed in relation to the type of binding site on the protein with which they interact. These are the colchicine, vinca alkaloid, rhizoxin/maytansine, and tubulin sulfhydryl binding sites. Also included are the agents which either bind at other sites or unknown sites on tubulin. The literature is reviewed up to October 1997. © 1998 John Wiley & Sons, Inc., Med Res Rev, 18, No. 4, 259–296, 1998.</description><subject>Antibiotics, Antineoplastic - pharmacology</subject><subject>antimitotic</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>binding site</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>cancer</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Chemical agents</subject><subject>Colchicine - pharmacology</subject><subject>Drug Design</subject><subject>Humans</subject><subject>Lactones - pharmacology</subject><subject>Macrolides</subject><subject>Maytansine - pharmacology</subject><subject>Medical sciences</subject><subject>Microtubules - chemistry</subject><subject>Microtubules - drug effects</subject><subject>Paclitaxel - pharmacology</subject><subject>Protein Binding</subject><subject>Spindle Apparatus - chemistry</subject><subject>Spindle Apparatus - drug effects</subject><subject>Sulfhydryl Reagents - pharmacology</subject><subject>tubulin</subject><subject>Tubulin - chemistry</subject><subject>Tubulin - drug effects</subject><subject>Tubulin Modulators</subject><subject>Tumors</subject><subject>Vinblastine - pharmacology</subject><subject>Vinca</subject><subject>Vincristine - pharmacology</subject><issn>0198-6325</issn><issn>1098-1128</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUGP0zAQhSMEWsrCT0DyAaHdQ8rYbuKku0Kq0mWpVOiBVt3byHGc1pAmxXZU9t-T0KpCAmlPtjVv3jzPFwS3FIYUgH24-jbLZtcU0iSklCVXNE0TENc0GY9uWZSOx5PZNPxyN-Uf-RCG2eKGhatnweDc8DwYAO3uMWfRy-CVc98BKI0ovwgu0jgesZQNgodlm7eVqYl0RBIv7UZ7UjaWyNobJWulLSlsu3FjMtno2jty2Bq1Jab22krlycH4LfFbTXbGN10LcXtTF5V-HbwoZeX0m9N5Gaw-3S2zz-F8cT_LJvNQccF5KDiDWACPmZRCJbkqRF4kIpc5BxGzotRaqO7fMhaRVkmqEqWhLCOhZKEYLfhl8P7ou7fNz1Y7jzvjlK4qWeumdZgAAB-NxJNCRjlwxuNOuDwKlW2cs7rEvTU7aR-RAvZkEHsy2C8a-0XjkQzSBEfYkUHsyGBPBjkCZgtkuOps357mt_lOF2fTE4qu_u5Ul07JqrTd8o07yxgHSNlf6Q6m0o__RHsi2X-C_Xl3tuHR1jivf51tpf2BseAiwvXXe8wepnO6zjiu-W9x28Sk</recordid><startdate>199807</startdate><enddate>199807</enddate><creator>Jordan, Allan</creator><creator>Hadfield, John A.</creator><creator>Lawrence, Nicholas J.</creator><creator>McGown, Alan T.</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>199807</creationdate><title>Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle</title><author>Jordan, Allan ; Hadfield, John A. ; Lawrence, Nicholas J. ; McGown, Alan T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3733-7320670362aa7c8bcd7bd87bab30762dfee7c980a675ec89c8ce0ff57cadc21d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Antibiotics, Antineoplastic - pharmacology</topic><topic>antimitotic</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>binding site</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>cancer</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Chemical agents</topic><topic>Colchicine - pharmacology</topic><topic>Drug Design</topic><topic>Humans</topic><topic>Lactones - pharmacology</topic><topic>Macrolides</topic><topic>Maytansine - pharmacology</topic><topic>Medical sciences</topic><topic>Microtubules - chemistry</topic><topic>Microtubules - drug effects</topic><topic>Paclitaxel - pharmacology</topic><topic>Protein Binding</topic><topic>Spindle Apparatus - chemistry</topic><topic>Spindle Apparatus - drug effects</topic><topic>Sulfhydryl Reagents - pharmacology</topic><topic>tubulin</topic><topic>Tubulin - chemistry</topic><topic>Tubulin - drug effects</topic><topic>Tubulin Modulators</topic><topic>Tumors</topic><topic>Vinblastine - pharmacology</topic><topic>Vinca</topic><topic>Vincristine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jordan, Allan</creatorcontrib><creatorcontrib>Hadfield, John A.</creatorcontrib><creatorcontrib>Lawrence, Nicholas J.</creatorcontrib><creatorcontrib>McGown, Alan T.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Medicinal research reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jordan, Allan</au><au>Hadfield, John A.</au><au>Lawrence, Nicholas J.</au><au>McGown, Alan T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle</atitle><jtitle>Medicinal research reviews</jtitle><addtitle>Med. Res. Rev</addtitle><date>1998-07</date><risdate>1998</risdate><volume>18</volume><issue>4</issue><spage>259</spage><epage>296</epage><pages>259-296</pages><issn>0198-6325</issn><eissn>1098-1128</eissn><coden>MRREDD</coden><abstract>Tubulin is the biochemical target for several clinically used anticancer drugs, including paclitaxel and the vinca alkaloids vincristine and vinblastine. This review describes both the natural and synthetic agents which are known to interact with tubulin. Syntheses of the more complex agents are referenced and the potential clinical use of the compounds is discussed. This review describes the biochemistry of tubulin, microtubules, and the mitotic spindle. The agents are discussed in relation to the type of binding site on the protein with which they interact. These are the colchicine, vinca alkaloid, rhizoxin/maytansine, and tubulin sulfhydryl binding sites. Also included are the agents which either bind at other sites or unknown sites on tubulin. 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| subjects | Antibiotics, Antineoplastic - pharmacology antimitotic Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antineoplastic Agents, Phytogenic - pharmacology binding site Binding Sites Biological and medical sciences cancer Carcinogenesis, carcinogens and anticarcinogens Chemical agents Colchicine - pharmacology Drug Design Humans Lactones - pharmacology Macrolides Maytansine - pharmacology Medical sciences Microtubules - chemistry Microtubules - drug effects Paclitaxel - pharmacology Protein Binding Spindle Apparatus - chemistry Spindle Apparatus - drug effects Sulfhydryl Reagents - pharmacology tubulin Tubulin - chemistry Tubulin - drug effects Tubulin Modulators Tumors Vinblastine - pharmacology Vinca Vincristine - pharmacology |
| title | Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle |
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