T47DCO cells, genetically unstable and containing estrogen receptor mutations, are a model for the progression of breast cancers to hormone resistance

We postulate that one mechanism for the progression of breast cancers to hormone resistance involves the acquisition of mutant estrogen receptors (ER)4 by genetically unstable cell subpopulations. The T47D human breast cancer cell line may be a model for such progression, having sublines that are ER...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1990-10, Vol.50 (19), p.6208-6217
Hauptverfasser:	Graham, 2nd, M L, Krett, N L, Miller, L A, Leslie, K K, Gordon, D F, Wood, W M, Wei, L L, Horwitz, K B
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence breast Breast Neoplasms - genetics Breast Neoplasms - pathology DNA, Neoplasm - analysis Drug Resistance - genetics Estradiol - pharmacology Gene Library Humans Molecular Sequence Data Mutation Phenotype Polyploidy Receptors, Estrogen - genetics Receptors, Progesterone - antagonists & inhibitors Receptors, Progesterone - drug effects Receptors, Progesterone - genetics T47DCO cells Tamoxifen - pharmacology Tumor Cells, Cultured
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