Bacterial adhesion on PEG modified polyurethane surfaces
Polyurethane surface was modified with poly(ethylene glycol) (mol. wt. 1000, PEG1k) carrying terminal hydroxyl, amino and sulfonate groups, poly(ethylene glucol) (mol. wt. 3350, PEG3.4k) and PEG3.4k-Heparin, respectively. These surfaces were investigatted for bacterial adhesion using S. epidermidis...
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| Veröffentlicht in: | Biomaterials 1998-04, Vol.19 (7), p.851-859 |
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| creator | Park, Ki Dong Kim, Young Soo Han, Dong Keun Kim, Young Ha Lee, Eun Hee Bae Suh, Hwal Choi, Kyu Suk |
| description | Polyurethane surface was modified with poly(ethylene glycol) (mol. wt. 1000, PEG1k) carrying terminal hydroxyl, amino and sulfonate groups, poly(ethylene glucol) (mol. wt. 3350, PEG3.4k) and PEG3.4k-Heparin, respectively. These surfaces were investigatted for bacterial adhesion using
S. epidermidis and
E. coli in tryptic soya broth (TSB), brain heart infusion (BHI), and human plasma. All PEG modified surfaces reduced bacterial adhesion significantly and the adhesion level differs depending on surfaces as well as media. In the case of PEG1k surfaces, no reduction of
S. epidermidis adhesion was demonstrated in TSB media, regardless of terminal functional groups of PEG1k. However, adhesioin in plasma was reduced to the different degree, depending on terminal groups of PEG1k (least adhesion on sulfonated PEG surface). Relatively longer PEG surface (PEG3.4k) and PEG3.4k-heparin surface minimized bacterial adhesion in both media. In the case of
E. coli adhesion, significant reduction in adherent bacteria was observed on all PEG1k, PEG3.4k, and PEG-heparin surfaces in both media compared to controls. In contrast, no reductioin in bacterial adhesion was demonstrated on poly(propylene glycol) (PPG1k) grafted PU surface as compared to control PU. These results suggest that surface modification with PEG1k-SO
3, PEG3.4k and PEG3.4k-heparin seems to be effective for prevention of bacterial adhesion and subsequent infection. |
| doi_str_mv | 10.1016/S0142-9612(97)00245-7 |
| format | Article |
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S. epidermidis and
E. coli in tryptic soya broth (TSB), brain heart infusion (BHI), and human plasma. All PEG modified surfaces reduced bacterial adhesion significantly and the adhesion level differs depending on surfaces as well as media. In the case of PEG1k surfaces, no reduction of
S. epidermidis adhesion was demonstrated in TSB media, regardless of terminal functional groups of PEG1k. However, adhesioin in plasma was reduced to the different degree, depending on terminal groups of PEG1k (least adhesion on sulfonated PEG surface). Relatively longer PEG surface (PEG3.4k) and PEG3.4k-heparin surface minimized bacterial adhesion in both media. In the case of
E. coli adhesion, significant reduction in adherent bacteria was observed on all PEG1k, PEG3.4k, and PEG-heparin surfaces in both media compared to controls. In contrast, no reductioin in bacterial adhesion was demonstrated on poly(propylene glycol) (PPG1k) grafted PU surface as compared to control PU. These results suggest that surface modification with PEG1k-SO
3, PEG3.4k and PEG3.4k-heparin seems to be effective for prevention of bacterial adhesion and subsequent infection.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/S0142-9612(97)00245-7</identifier><identifier>PMID: 9663762</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Bacterial Adhesion ; Biological and medical sciences ; Cattle ; Culture Media ; Escherichia coli - growth & development ; Heparin ; Heparin - chemistry ; Humans ; Medical sciences ; Poly(ethylene glycol) ; Polyethylene Glycols - chemistry ; Polyurethanes - chemistry ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Staphylococcus epidermidis - growth & development ; Sulfonic Acids - chemistry ; Surface modification ; Surface Properties ; Technology. Biomaterials. Equipments. Material. Instrumentation</subject><ispartof>Biomaterials, 1998-04, Vol.19 (7), p.851-859</ispartof><rights>1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-cc7dae54f869aa9cd0571b5b065f154d07bb18a880d93e685366aeb65bb443873</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0142-9612(97)00245-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2256210$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9663762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Ki Dong</creatorcontrib><creatorcontrib>Kim, Young Soo</creatorcontrib><creatorcontrib>Han, Dong Keun</creatorcontrib><creatorcontrib>Kim, Young Ha</creatorcontrib><creatorcontrib>Lee, Eun Hee Bae</creatorcontrib><creatorcontrib>Suh, Hwal</creatorcontrib><creatorcontrib>Choi, Kyu Suk</creatorcontrib><title>Bacterial adhesion on PEG modified polyurethane surfaces</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Polyurethane surface was modified with poly(ethylene glycol) (mol. wt. 1000, PEG1k) carrying terminal hydroxyl, amino and sulfonate groups, poly(ethylene glucol) (mol. wt. 3350, PEG3.4k) and PEG3.4k-Heparin, respectively. These surfaces were investigatted for bacterial adhesion using
S. epidermidis and
E. coli in tryptic soya broth (TSB), brain heart infusion (BHI), and human plasma. All PEG modified surfaces reduced bacterial adhesion significantly and the adhesion level differs depending on surfaces as well as media. In the case of PEG1k surfaces, no reduction of
S. epidermidis adhesion was demonstrated in TSB media, regardless of terminal functional groups of PEG1k. However, adhesioin in plasma was reduced to the different degree, depending on terminal groups of PEG1k (least adhesion on sulfonated PEG surface). Relatively longer PEG surface (PEG3.4k) and PEG3.4k-heparin surface minimized bacterial adhesion in both media. In the case of
E. coli adhesion, significant reduction in adherent bacteria was observed on all PEG1k, PEG3.4k, and PEG-heparin surfaces in both media compared to controls. In contrast, no reductioin in bacterial adhesion was demonstrated on poly(propylene glycol) (PPG1k) grafted PU surface as compared to control PU. These results suggest that surface modification with PEG1k-SO
3, PEG3.4k and PEG3.4k-heparin seems to be effective for prevention of bacterial adhesion and subsequent infection.</description><subject>Animals</subject><subject>Bacterial Adhesion</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Culture Media</subject><subject>Escherichia coli - growth & development</subject><subject>Heparin</subject><subject>Heparin - chemistry</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Poly(ethylene glycol)</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polyurethanes - chemistry</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Staphylococcus epidermidis - growth & development</subject><subject>Sulfonic Acids - chemistry</subject><subject>Surface modification</subject><subject>Surface Properties</subject><subject>Technology. Biomaterials. Equipments. Material. Instrumentation</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LwzAUhoMoc378hEEvRPSimqT5vBKVOQVBQb0OaXLKIt06k1bYv7dzZbeDwCGcJznveRCaEHxDMBG3H5gwmmtB6JWW1xhTxnN5gMZESZVzjfkhGu-QY3SS0jfu75jRERppIQop6BipB-taiMHWmfVzSKFZZv15n86yReNDFcBnq6ZedxHauV1ClrpYWQfpDB1Vtk5wPtRT9PU0_Xx8zl_fZi-P96-544Vqc-ekt8BZpYS2VjuPuSQlL7HgFeHMY1mWRFmlsNcFCMULISyUgpclY4WSxSm63P67is1PB6k1i5Ac1HUfpumSUbhfHRO1F6SSFZIx3YN8C7rYpBShMqsYFjauDcFmo9b8qzUbb0ZL86_WbJJMhgFduQC_ezW47PsXQ98mZ-sq2qULaYdRygUluMfuthj01n4DRJNcgKUDHyK41vgm7AnyB5BCk84</recordid><startdate>19980401</startdate><enddate>19980401</enddate><creator>Park, Ki Dong</creator><creator>Kim, Young Soo</creator><creator>Han, Dong Keun</creator><creator>Kim, Young Ha</creator><creator>Lee, Eun Hee Bae</creator><creator>Suh, Hwal</creator><creator>Choi, Kyu Suk</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope></search><sort><creationdate>19980401</creationdate><title>Bacterial adhesion on PEG modified polyurethane surfaces</title><author>Park, Ki Dong ; Kim, Young Soo ; Han, Dong Keun ; Kim, Young Ha ; Lee, Eun Hee Bae ; Suh, Hwal ; Choi, Kyu Suk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-cc7dae54f869aa9cd0571b5b065f154d07bb18a880d93e685366aeb65bb443873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Bacterial Adhesion</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Culture Media</topic><topic>Escherichia coli - growth & development</topic><topic>Heparin</topic><topic>Heparin - chemistry</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Poly(ethylene glycol)</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polyurethanes - chemistry</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Staphylococcus epidermidis - growth & development</topic><topic>Sulfonic Acids - chemistry</topic><topic>Surface modification</topic><topic>Surface Properties</topic><topic>Technology. Biomaterials. Equipments. Material. Instrumentation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Ki Dong</creatorcontrib><creatorcontrib>Kim, Young Soo</creatorcontrib><creatorcontrib>Han, Dong Keun</creatorcontrib><creatorcontrib>Kim, Young Ha</creatorcontrib><creatorcontrib>Lee, Eun Hee Bae</creatorcontrib><creatorcontrib>Suh, Hwal</creatorcontrib><creatorcontrib>Choi, Kyu Suk</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Ki Dong</au><au>Kim, Young Soo</au><au>Han, Dong Keun</au><au>Kim, Young Ha</au><au>Lee, Eun Hee Bae</au><au>Suh, Hwal</au><au>Choi, Kyu Suk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bacterial adhesion on PEG modified polyurethane surfaces</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>1998-04-01</date><risdate>1998</risdate><volume>19</volume><issue>7</issue><spage>851</spage><epage>859</epage><pages>851-859</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Polyurethane surface was modified with poly(ethylene glycol) (mol. wt. 1000, PEG1k) carrying terminal hydroxyl, amino and sulfonate groups, poly(ethylene glucol) (mol. wt. 3350, PEG3.4k) and PEG3.4k-Heparin, respectively. These surfaces were investigatted for bacterial adhesion using
S. epidermidis and
E. coli in tryptic soya broth (TSB), brain heart infusion (BHI), and human plasma. All PEG modified surfaces reduced bacterial adhesion significantly and the adhesion level differs depending on surfaces as well as media. In the case of PEG1k surfaces, no reduction of
S. epidermidis adhesion was demonstrated in TSB media, regardless of terminal functional groups of PEG1k. However, adhesioin in plasma was reduced to the different degree, depending on terminal groups of PEG1k (least adhesion on sulfonated PEG surface). Relatively longer PEG surface (PEG3.4k) and PEG3.4k-heparin surface minimized bacterial adhesion in both media. In the case of
E. coli adhesion, significant reduction in adherent bacteria was observed on all PEG1k, PEG3.4k, and PEG-heparin surfaces in both media compared to controls. In contrast, no reductioin in bacterial adhesion was demonstrated on poly(propylene glycol) (PPG1k) grafted PU surface as compared to control PU. These results suggest that surface modification with PEG1k-SO
3, PEG3.4k and PEG3.4k-heparin seems to be effective for prevention of bacterial adhesion and subsequent infection.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9663762</pmid><doi>10.1016/S0142-9612(97)00245-7</doi><tpages>9</tpages></addata></record> |
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| ispartof | Biomaterials, 1998-04, Vol.19 (7), p.851-859 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Bacterial Adhesion Biological and medical sciences Cattle Culture Media Escherichia coli - growth & development Heparin Heparin - chemistry Humans Medical sciences Poly(ethylene glycol) Polyethylene Glycols - chemistry Polyurethanes - chemistry Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Staphylococcus epidermidis - growth & development Sulfonic Acids - chemistry Surface modification Surface Properties Technology. Biomaterials. Equipments. Material. Instrumentation |
| title | Bacterial adhesion on PEG modified polyurethane surfaces |
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