Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury
The mechanism of immunodepression after brain injury is not yet clear. Here we demonstrate rapid systemic release of the immunoinhibitory cytokine interleukin-10, monocytic deactivation and a high incidence of infection in patients with ‘sympathetic storm’ due to acute accidental or iatrogenic brain...
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| Veröffentlicht in: | Nature medicine 1998-07, Vol.4 (7), p.808-813 |
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| creator | Woiciechowsky, Christian Asadullah, Khusru Nestler, Dirk Eberhardt, Beatrice Platzer, Cornelia Schöning, Britta Glöckner, Frauke Lanksch, Wolfgang R. Volk, Hans-Dieter Döcke, Wolf-Diatrich |
| description | The mechanism of immunodepression after brain injury is not yet clear. Here we demonstrate rapid systemic release of the immunoinhibitory cytokine interleukin-10, monocytic deactivation and a high incidence of infection in patients with ‘sympathetic storm’ due to acute accidental or iatrogenic brain trauma.
In vitro
studies showed that within minutes catecholamines trigger the secretion of interleukin-10 from unstimulated monocytes through a β-adrenoreceptor-mediated, cAMP/protein kinase A-dependent pathway. We found that in a rat model of acute brain injury, the βreceptor antagonist propranolol prevented the increase of interleukin-10 plasma levels. Rapid monocytic interleukin-10 release after sympathetic activation may represent a common pathway for immunodepression induced by stress and injury. |
| doi_str_mv | 10.1038/nm0798-808 |
| format | Article |
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In vitro
studies showed that within minutes catecholamines trigger the secretion of interleukin-10 from unstimulated monocytes through a β-adrenoreceptor-mediated, cAMP/protein kinase A-dependent pathway. We found that in a rat model of acute brain injury, the βreceptor antagonist propranolol prevented the increase of interleukin-10 plasma levels. Rapid monocytic interleukin-10 release after sympathetic activation may represent a common pathway for immunodepression induced by stress and injury.</description><identifier>ISSN: 1078-8956</identifier><identifier>EISSN: 1546-170X</identifier><identifier>DOI: 10.1038/nm0798-808</identifier><identifier>PMID: 9662372</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Adrenergic beta-Antagonists - pharmacology ; Adult ; Aged ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Brain - surgery ; Brain Injuries - blood ; Brain Injuries - complications ; Brain Injuries - physiopathology ; Brain Neoplasms - blood ; Brain Neoplasms - surgery ; Brain Stem - physiopathology ; Cancer Research ; Catecholamines - pharmacology ; Humans ; Immune Tolerance ; Infectious Diseases ; Interleukin-10 - blood ; Male ; Metabolic Diseases ; Middle Aged ; Molecular Medicine ; Neoplasms, Nerve Tissue - blood ; Neoplasms, Nerve Tissue - surgery ; Neurosciences ; Propranolol - pharmacology ; Rats ; Rats, Sprague-Dawley ; Sympathetic Nervous System - drug effects ; Sympathetic Nervous System - physiopathology ; Sympatholytics - pharmacology ; Sympathomimetics - pharmacology</subject><ispartof>Nature medicine, 1998-07, Vol.4 (7), p.808-813</ispartof><rights>Springer Nature America, Inc. 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-c44f37c543ad3f81214108782da4d54d82f47e8117082a7ae8808177ea5af90a3</citedby><cites>FETCH-LOGICAL-c415t-c44f37c543ad3f81214108782da4d54d82f47e8117082a7ae8808177ea5af90a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nm0798-808$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nm0798-808$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9662372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Woiciechowsky, Christian</creatorcontrib><creatorcontrib>Asadullah, Khusru</creatorcontrib><creatorcontrib>Nestler, Dirk</creatorcontrib><creatorcontrib>Eberhardt, Beatrice</creatorcontrib><creatorcontrib>Platzer, Cornelia</creatorcontrib><creatorcontrib>Schöning, Britta</creatorcontrib><creatorcontrib>Glöckner, Frauke</creatorcontrib><creatorcontrib>Lanksch, Wolfgang R.</creatorcontrib><creatorcontrib>Volk, Hans-Dieter</creatorcontrib><creatorcontrib>Döcke, Wolf-Diatrich</creatorcontrib><title>Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury</title><title>Nature medicine</title><addtitle>Nat Med</addtitle><addtitle>Nat Med</addtitle><description>The mechanism of immunodepression after brain injury is not yet clear. Here we demonstrate rapid systemic release of the immunoinhibitory cytokine interleukin-10, monocytic deactivation and a high incidence of infection in patients with ‘sympathetic storm’ due to acute accidental or iatrogenic brain trauma.
In vitro
studies showed that within minutes catecholamines trigger the secretion of interleukin-10 from unstimulated monocytes through a β-adrenoreceptor-mediated, cAMP/protein kinase A-dependent pathway. We found that in a rat model of acute brain injury, the βreceptor antagonist propranolol prevented the increase of interleukin-10 plasma levels. Rapid monocytic interleukin-10 release after sympathetic activation may represent a common pathway for immunodepression induced by stress and injury.</description><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Adult</subject><subject>Aged</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain - surgery</subject><subject>Brain Injuries - blood</subject><subject>Brain Injuries - complications</subject><subject>Brain Injuries - physiopathology</subject><subject>Brain Neoplasms - blood</subject><subject>Brain Neoplasms - surgery</subject><subject>Brain Stem - physiopathology</subject><subject>Cancer Research</subject><subject>Catecholamines - pharmacology</subject><subject>Humans</subject><subject>Immune Tolerance</subject><subject>Infectious Diseases</subject><subject>Interleukin-10 - blood</subject><subject>Male</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Neoplasms, Nerve Tissue - blood</subject><subject>Neoplasms, Nerve Tissue - surgery</subject><subject>Neurosciences</subject><subject>Propranolol - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sympathetic Nervous System - drug effects</subject><subject>Sympathetic Nervous System - physiopathology</subject><subject>Sympatholytics - pharmacology</subject><subject>Sympathomimetics - pharmacology</subject><issn>1078-8956</issn><issn>1546-170X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1LxDAQxYMo67p68S705EGpJk3SpEdZ_ALBgwreSraZrtlt0zVJhf73Zu3iSfCSCfN-82DeIHRK8BXBVF7bFotCphLLPTQlnOUpEfh9P_6xiO2C54foyPsVxphiXkzQpMjzjIpsitYvQ7tR4QOCqRJVBfOlgulsEpxZLsH5xA8-QBtFYwO4Bvq1sSnBiYMGlIfYTkzb9rbTsHHg_XbYWN1XoJPFkCyc2hJ21bvhGB3UqvFwsqsz9HZ3-zp_SJ-e7x_nN09pxQgP8WU1FRVnVGlaS5IRRrAUMtOKac60zGomQJK4o8yUUCDj4kQIUFzVBVZ0hs5H343rPnvwoWyNr6BplIWu96XEP0Fk_4Ik54xQhiN4MYKV67x3UJcbZ1rlhpLgcnuCcjxBtJYRPtu59osW9C-6yzzql6Puo2JjyOWq652Nifzl9g32aJDf</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>Woiciechowsky, Christian</creator><creator>Asadullah, Khusru</creator><creator>Nestler, Dirk</creator><creator>Eberhardt, Beatrice</creator><creator>Platzer, Cornelia</creator><creator>Schöning, Britta</creator><creator>Glöckner, Frauke</creator><creator>Lanksch, Wolfgang R.</creator><creator>Volk, Hans-Dieter</creator><creator>Döcke, Wolf-Diatrich</creator><general>Nature Publishing Group US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19980701</creationdate><title>Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury</title><author>Woiciechowsky, Christian ; Asadullah, Khusru ; Nestler, Dirk ; Eberhardt, Beatrice ; Platzer, Cornelia ; Schöning, Britta ; Glöckner, Frauke ; Lanksch, Wolfgang R. ; Volk, Hans-Dieter ; Döcke, Wolf-Diatrich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-c44f37c543ad3f81214108782da4d54d82f47e8117082a7ae8808177ea5af90a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Adult</topic><topic>Aged</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain - surgery</topic><topic>Brain Injuries - blood</topic><topic>Brain Injuries - complications</topic><topic>Brain Injuries - physiopathology</topic><topic>Brain Neoplasms - blood</topic><topic>Brain Neoplasms - surgery</topic><topic>Brain Stem - physiopathology</topic><topic>Cancer Research</topic><topic>Catecholamines - pharmacology</topic><topic>Humans</topic><topic>Immune Tolerance</topic><topic>Infectious Diseases</topic><topic>Interleukin-10 - blood</topic><topic>Male</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Neoplasms, Nerve Tissue - blood</topic><topic>Neoplasms, Nerve Tissue - surgery</topic><topic>Neurosciences</topic><topic>Propranolol - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sympathetic Nervous System - drug effects</topic><topic>Sympathetic Nervous System - physiopathology</topic><topic>Sympatholytics - pharmacology</topic><topic>Sympathomimetics - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Woiciechowsky, Christian</creatorcontrib><creatorcontrib>Asadullah, Khusru</creatorcontrib><creatorcontrib>Nestler, Dirk</creatorcontrib><creatorcontrib>Eberhardt, Beatrice</creatorcontrib><creatorcontrib>Platzer, Cornelia</creatorcontrib><creatorcontrib>Schöning, Britta</creatorcontrib><creatorcontrib>Glöckner, Frauke</creatorcontrib><creatorcontrib>Lanksch, Wolfgang R.</creatorcontrib><creatorcontrib>Volk, Hans-Dieter</creatorcontrib><creatorcontrib>Döcke, Wolf-Diatrich</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Woiciechowsky, Christian</au><au>Asadullah, Khusru</au><au>Nestler, Dirk</au><au>Eberhardt, Beatrice</au><au>Platzer, Cornelia</au><au>Schöning, Britta</au><au>Glöckner, Frauke</au><au>Lanksch, Wolfgang R.</au><au>Volk, Hans-Dieter</au><au>Döcke, Wolf-Diatrich</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury</atitle><jtitle>Nature medicine</jtitle><stitle>Nat Med</stitle><addtitle>Nat Med</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>4</volume><issue>7</issue><spage>808</spage><epage>813</epage><pages>808-813</pages><issn>1078-8956</issn><eissn>1546-170X</eissn><abstract>The mechanism of immunodepression after brain injury is not yet clear. Here we demonstrate rapid systemic release of the immunoinhibitory cytokine interleukin-10, monocytic deactivation and a high incidence of infection in patients with ‘sympathetic storm’ due to acute accidental or iatrogenic brain trauma.
In vitro
studies showed that within minutes catecholamines trigger the secretion of interleukin-10 from unstimulated monocytes through a β-adrenoreceptor-mediated, cAMP/protein kinase A-dependent pathway. We found that in a rat model of acute brain injury, the βreceptor antagonist propranolol prevented the increase of interleukin-10 plasma levels. Rapid monocytic interleukin-10 release after sympathetic activation may represent a common pathway for immunodepression induced by stress and injury.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>9662372</pmid><doi>10.1038/nm0798-808</doi><tpages>6</tpages></addata></record> |
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| subjects | Adrenergic beta-Antagonists - pharmacology Adult Aged Animals Biomedical and Life Sciences Biomedicine Brain - surgery Brain Injuries - blood Brain Injuries - complications Brain Injuries - physiopathology Brain Neoplasms - blood Brain Neoplasms - surgery Brain Stem - physiopathology Cancer Research Catecholamines - pharmacology Humans Immune Tolerance Infectious Diseases Interleukin-10 - blood Male Metabolic Diseases Middle Aged Molecular Medicine Neoplasms, Nerve Tissue - blood Neoplasms, Nerve Tissue - surgery Neurosciences Propranolol - pharmacology Rats Rats, Sprague-Dawley Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiopathology Sympatholytics - pharmacology Sympathomimetics - pharmacology |
| title | Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury |
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