Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia

During melanocyte development, the cytokine Steel factor activates its receptor c-Kit, initiating a signal transduction cascade, which is vital for lineage determination via unknown downstream nuclear targets. c-Kit has recently been found to trigger mitogen-activated protein kinase-mediated phospho...

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Veröffentlicht in:	The Journal of biological chemistry 1998-07, Vol.273 (29), p.17983-17986
Hauptverfasser:	Price, E R, Ding, H F, Badalian, T, Bhattacharya, S, Takemoto, C, Yao, T P, Hemesath, T J, Fisher, D E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium-Calmodulin-Dependent Protein Kinases - metabolism CREB-Binding Protein Cricetinae Dimerization DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology E1A-Associated p300 Protein Enzyme Activation Humans Melanocytes - physiology Mice Microphthalmia-Associated Transcription Factor Nuclear Proteins - physiology Phosphorylation Protein Binding Proto-Oncogene Proteins c-kit - physiology Rabbits Signal Transduction Stem Cell Factor - physiology Trans-Activators - physiology Transcription Factors - physiology Transcriptional Activation Tumor Cells, Cultured
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