Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry

Viral induction of autoimmunity is thought to occur by either bystander T-cell activation or molecular mimicry. Coxsackie B4 virus is strongly associated with the development of insulin-dependent diabetes mellitus in humans and shares sequence similarity with the islet autoantigen glutamic acid deca...

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Veröffentlicht in:	Nature medicine 1998-07, Vol.4 (7), p.781-785
Hauptverfasser:	Horwitz, Marc S, Bradley, Linda M, Harbertson, Judith, Krahl, Troy, Lee, Jae, Sarvennick, Nora
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biomedical and Life Sciences Biomedicine Cancer Research Cells, Cultured Chaperonin 60 - immunology Coxsackievirus Infections - immunology Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - virology Disease Models, Animal Enterovirus B, Human - immunology Female Glutamate Decarboxylase - immunology HeLa Cells Humans Hyaluronan Receptors - immunology Infectious Diseases L-Selectin - immunology Lymphocytic Choriomeningitis - immunology Metabolic Diseases Mice Mice, Inbred NOD Mice, SCID Mice, Transgenic Molecular Medicine Molecular Sequence Data Neurosciences Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - immunology Receptors, Interleukin-2 - immunology T-Lymphocytes - immunology
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