Hereditary cerebral hemorrhage with amyloidosis ― Dutch type : Tc-99m HM-PAO single photon emission computed tomography
We performed single photon emission computed tomography (SPECT) and cerebral CT-scans in nine patients with hereditary cerebral amyloid angiopathy. CT-scans showed 23 focal hypodense lesions, 13 of which were visible on SPECT as a CBF-defect. One patient showed a CBF-defect on SPECT without CT-scan...
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| Veröffentlicht in: | Neuroradiology 1990-03, Vol.32 (2), p.142-145 |
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| container_title | Neuroradiology |
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| creator | HAAN, J VAN KROONENBURGH, M. J. P. G ALGRA, P. R BURUMA, O. J. S PAUWELS, E. K. J BLOEM, B. R ROOS, R. A. C |
| description | We performed single photon emission computed tomography (SPECT) and cerebral CT-scans in nine patients with hereditary cerebral amyloid angiopathy. CT-scans showed 23 focal hypodense lesions, 13 of which were visible on SPECT as a CBF-defect. One patient showed a CBF-defect on SPECT without CT-scan lesion and had a cerebral hemorrhage three months later in that particular region. In two additional patients, who were 50% at risk for this autosomal dominant disease, CBF-defects on SPECT, but no cortical lesions on CT-scan were found. CT-scans may be more sensitive than SPECT to detect chronic lesions caused by cerebral hemorrhages, but another possibility is that hemorrhages do not always lead to persistent CBF-defects. SPECT can show the effect of amyloid deposits on CBF before the angiopathy causes clinical symptoms. |
| doi_str_mv | 10.1007/BF00588564 |
| format | Article |
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SPECT can show the effect of amyloid deposits on CBF before the angiopathy causes clinical symptoms.</description><identifier>ISSN: 0028-3940</identifier><identifier>EISSN: 1432-1920</identifier><identifier>DOI: 10.1007/BF00588564</identifier><identifier>PMID: 2398939</identifier><identifier>CODEN: NRDYAB</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Amyloidosis - diagnostic imaging ; Amyloidosis - genetics ; Biological and medical sciences ; Brain Diseases - diagnostic imaging ; Brain Diseases - genetics ; Cerebral Hemorrhage - diagnostic imaging ; Cerebral Hemorrhage - genetics ; Cerebrovascular Circulation ; Cerebrovascular Disorders - diagnostic imaging ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Neurology ; Organotechnetium Compounds ; Oximes ; Single-Blind Method ; Technetium Tc 99m Exametazime ; Tomography, Emission-Computed, Single-Photon ; Tomography, X-Ray Computed ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Neuroradiology, 1990-03, Vol.32 (2), p.142-145</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c185t-9cfa837095e80aa6c11f4b38273555d39d9e2bbb05a530cd69bdface3dca80c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6950126$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2398939$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HAAN, J</creatorcontrib><creatorcontrib>VAN KROONENBURGH, M. 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In two additional patients, who were 50% at risk for this autosomal dominant disease, CBF-defects on SPECT, but no cortical lesions on CT-scan were found. CT-scans may be more sensitive than SPECT to detect chronic lesions caused by cerebral hemorrhages, but another possibility is that hemorrhages do not always lead to persistent CBF-defects. SPECT can show the effect of amyloid deposits on CBF before the angiopathy causes clinical symptoms.</description><subject>Amyloidosis - diagnostic imaging</subject><subject>Amyloidosis - genetics</subject><subject>Biological and medical sciences</subject><subject>Brain Diseases - diagnostic imaging</subject><subject>Brain Diseases - genetics</subject><subject>Cerebral Hemorrhage - diagnostic imaging</subject><subject>Cerebral Hemorrhage - genetics</subject><subject>Cerebrovascular Circulation</subject><subject>Cerebrovascular Disorders - diagnostic imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Organotechnetium Compounds</subject><subject>Oximes</subject><subject>Single-Blind Method</subject><subject>Technetium Tc 99m Exametazime</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>Tomography, X-Ray Computed</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0028-3940</issn><issn>1432-1920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1q3DAUhUVpSCdJN90XtChdBNxcWZYtZZf_KSSki3RtZOl6rGKPHEmmeJeX6AvmSeKQIV3dA-fjcPkI-cLgBwOoTs6vAYSUoiw-kBUreJ4xlcNHsgLIZcZVAZ_IQYx_AIBXvNon-zlXUnG1IvMaA1qXdJipWWITdE87HHwInd4g_etSR_Uw995ZH12kz0__6OWUTEfTPCI9pQ8mU2qg67vs19k9jW676ZGOnU9-S3FwMbolGD-MU0JLkx_8Juixm4_IXqv7iJ9395D8vr56uFhnt_c3Py_ObjPDpEiZMq2WvAIlUILWpWGsLRou84oLISxXVmHeNA0ILTgYW6rGttogt0ZLMJIfku9vu2PwjxPGVC9PGex7vUU_xbpSShVV9Qoev4Em-BgDtvUY3LCIqRnUr57r_54X-OtudWoGtO_oTuzSf9v1Ohrdt0FvjYvvWKkEsLzkL_YghrI</recordid><startdate>199003</startdate><enddate>199003</enddate><creator>HAAN, J</creator><creator>VAN KROONENBURGH, M. 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J. P. G</creatorcontrib><creatorcontrib>ALGRA, P. R</creatorcontrib><creatorcontrib>BURUMA, O. J. S</creatorcontrib><creatorcontrib>PAUWELS, E. K. J</creatorcontrib><creatorcontrib>BLOEM, B. R</creatorcontrib><creatorcontrib>ROOS, R. A. C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroradiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HAAN, J</au><au>VAN KROONENBURGH, M. J. P. G</au><au>ALGRA, P. R</au><au>BURUMA, O. J. S</au><au>PAUWELS, E. K. J</au><au>BLOEM, B. R</au><au>ROOS, R. A. C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hereditary cerebral hemorrhage with amyloidosis ― Dutch type : Tc-99m HM-PAO single photon emission computed tomography</atitle><jtitle>Neuroradiology</jtitle><addtitle>Neuroradiology</addtitle><date>1990-03</date><risdate>1990</risdate><volume>32</volume><issue>2</issue><spage>142</spage><epage>145</epage><pages>142-145</pages><issn>0028-3940</issn><eissn>1432-1920</eissn><coden>NRDYAB</coden><abstract>We performed single photon emission computed tomography (SPECT) and cerebral CT-scans in nine patients with hereditary cerebral amyloid angiopathy. CT-scans showed 23 focal hypodense lesions, 13 of which were visible on SPECT as a CBF-defect. One patient showed a CBF-defect on SPECT without CT-scan lesion and had a cerebral hemorrhage three months later in that particular region. In two additional patients, who were 50% at risk for this autosomal dominant disease, CBF-defects on SPECT, but no cortical lesions on CT-scan were found. CT-scans may be more sensitive than SPECT to detect chronic lesions caused by cerebral hemorrhages, but another possibility is that hemorrhages do not always lead to persistent CBF-defects. SPECT can show the effect of amyloid deposits on CBF before the angiopathy causes clinical symptoms.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>2398939</pmid><doi>10.1007/BF00588564</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroradiology, 1990-03, Vol.32 (2), p.142-145 |
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| subjects | Amyloidosis - diagnostic imaging Amyloidosis - genetics Biological and medical sciences Brain Diseases - diagnostic imaging Brain Diseases - genetics Cerebral Hemorrhage - diagnostic imaging Cerebral Hemorrhage - genetics Cerebrovascular Circulation Cerebrovascular Disorders - diagnostic imaging Female Humans Male Medical sciences Middle Aged Neurology Organotechnetium Compounds Oximes Single-Blind Method Technetium Tc 99m Exametazime Tomography, Emission-Computed, Single-Photon Tomography, X-Ray Computed Vascular diseases and vascular malformations of the nervous system |
| title | Hereditary cerebral hemorrhage with amyloidosis ― Dutch type : Tc-99m HM-PAO single photon emission computed tomography |
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