Pharmacokinetics of glycopyrronium in parturients
Summary A sensitive radioreceptor assay was used to determine the pharmacokinetics of glycopyrronium 6 μg/kg after intramuscular (deltoid muscle) administration in eight Caesarean section patients. A fast absorption rate was found with a mean maximum plasma concentration (Cmax of 6.3 (SD 1.5) ng/ml,...
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| Veröffentlicht in: | Anaesthesia 1990-08, Vol.45 (8), p.634-637 |
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| creator | ALI‐MELKKILÄ, T. KAILA, T. KANTO, J. IISALO, E. |
| description | Summary
A sensitive radioreceptor assay was used to determine the pharmacokinetics of glycopyrronium 6 μg/kg after intramuscular (deltoid muscle) administration in eight Caesarean section patients. A fast absorption rate was found with a mean maximum plasma concentration (Cmax of 6.3 (SD 1.5) ng/ml, a mean time to Cmax (Tmax) of 10.0 (3.8) minutes and the elimination half‐life (Tl of 33.4 (1.92). The respective AUC0–8 h value was 5.61 (1.27) hours ng/ml. This dose produced a significant increase in the maternal heart rate after 10 minutes (p < 0.05) and an antisialogogue effect after 30 minutes (p < 0.05) of the drug injection. Almost half of drug (48.3%) was excreted into the urine within 3 hours. There were no measurable levels of glycopyrronium in the lumbar cerebrospinal fluid (CSF) after 60 minutes of drug injection. The concentrations of glycopyrronium in the umbilical venous (0.28 (0.25) ng/ml) and in the umbilical arterial (0.18 (0.11) ng/ml) plasma after 86 minutes of drug injection were low and clinically insignificant, as was the case in the amniotic fluid (0.15 (0.08) ng/ml). |
| doi_str_mv | 10.1111/j.1365-2044.1990.tb14385.x |
| format | Article |
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A sensitive radioreceptor assay was used to determine the pharmacokinetics of glycopyrronium 6 μg/kg after intramuscular (deltoid muscle) administration in eight Caesarean section patients. A fast absorption rate was found with a mean maximum plasma concentration (Cmax of 6.3 (SD 1.5) ng/ml, a mean time to Cmax (Tmax) of 10.0 (3.8) minutes and the elimination half‐life (Tl of 33.4 (1.92). The respective AUC0–8 h value was 5.61 (1.27) hours ng/ml. This dose produced a significant increase in the maternal heart rate after 10 minutes (p < 0.05) and an antisialogogue effect after 30 minutes (p < 0.05) of the drug injection. Almost half of drug (48.3%) was excreted into the urine within 3 hours. There were no measurable levels of glycopyrronium in the lumbar cerebrospinal fluid (CSF) after 60 minutes of drug injection. The concentrations of glycopyrronium in the umbilical venous (0.28 (0.25) ng/ml) and in the umbilical arterial (0.18 (0.11) ng/ml) plasma after 86 minutes of drug injection were low and clinically insignificant, as was the case in the amniotic fluid (0.15 (0.08) ng/ml).</description><identifier>ISSN: 0003-2409</identifier><identifier>EISSN: 1365-2044</identifier><identifier>DOI: 10.1111/j.1365-2044.1990.tb14385.x</identifier><identifier>PMID: 2400072</identifier><identifier>CODEN: ANASAB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Anesthesia, Obstetrical ; Biological and medical sciences ; Cesarean Section ; Female ; Fetal Blood - analysis ; Genital system. Reproduction ; Glycopyrrolate - blood ; Glycopyrrolate - pharmacokinetics ; Glycopyrrolate - pharmacology ; Heart Rate - drug effects ; Humans ; Injections, Intramuscular ; Medical sciences ; Parasympathetic nervous system; glycopyrronium ; Pharmacokinetics ; Pharmacology. Drug treatments ; Pregnancy ; Pyrrolidines - pharmacokinetics ; Salivation - drug effects</subject><ispartof>Anaesthesia, 1990-08, Vol.45 (8), p.634-637</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4524-a0f078e8ea9f6a6658c2fdcebe5e73188d3ca889fd59f404499b66d89c2e9ddd3</citedby><cites>FETCH-LOGICAL-c4524-a0f078e8ea9f6a6658c2fdcebe5e73188d3ca889fd59f404499b66d89c2e9ddd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2044.1990.tb14385.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2044.1990.tb14385.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19247852$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2400072$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ALI‐MELKKILÄ, T.</creatorcontrib><creatorcontrib>KAILA, T.</creatorcontrib><creatorcontrib>KANTO, J.</creatorcontrib><creatorcontrib>IISALO, E.</creatorcontrib><title>Pharmacokinetics of glycopyrronium in parturients</title><title>Anaesthesia</title><addtitle>Anaesthesia</addtitle><description>Summary
A sensitive radioreceptor assay was used to determine the pharmacokinetics of glycopyrronium 6 μg/kg after intramuscular (deltoid muscle) administration in eight Caesarean section patients. A fast absorption rate was found with a mean maximum plasma concentration (Cmax of 6.3 (SD 1.5) ng/ml, a mean time to Cmax (Tmax) of 10.0 (3.8) minutes and the elimination half‐life (Tl of 33.4 (1.92). The respective AUC0–8 h value was 5.61 (1.27) hours ng/ml. This dose produced a significant increase in the maternal heart rate after 10 minutes (p < 0.05) and an antisialogogue effect after 30 minutes (p < 0.05) of the drug injection. Almost half of drug (48.3%) was excreted into the urine within 3 hours. There were no measurable levels of glycopyrronium in the lumbar cerebrospinal fluid (CSF) after 60 minutes of drug injection. The concentrations of glycopyrronium in the umbilical venous (0.28 (0.25) ng/ml) and in the umbilical arterial (0.18 (0.11) ng/ml) plasma after 86 minutes of drug injection were low and clinically insignificant, as was the case in the amniotic fluid (0.15 (0.08) ng/ml).</description><subject>Adult</subject><subject>Anesthesia, Obstetrical</subject><subject>Biological and medical sciences</subject><subject>Cesarean Section</subject><subject>Female</subject><subject>Fetal Blood - analysis</subject><subject>Genital system. Reproduction</subject><subject>Glycopyrrolate - blood</subject><subject>Glycopyrrolate - pharmacokinetics</subject><subject>Glycopyrrolate - pharmacology</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Injections, Intramuscular</subject><subject>Medical sciences</subject><subject>Parasympathetic nervous system; glycopyrronium</subject><subject>Pharmacokinetics</subject><subject>Pharmacology. Drug treatments</subject><subject>Pregnancy</subject><subject>Pyrrolidines - pharmacokinetics</subject><subject>Salivation - drug effects</subject><issn>0003-2409</issn><issn>1365-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkFtLxDAQhYMo63r5CUIR9K01t7aJL7Is6wUW9UGfQ5ommrU3kxa3_96WLeuz8zIw58yc4QPgEsEIDXWziRBJ4hBDSiPEOYzaDFHC4mh7AOZ76RDMIYQkxBTyY3Di_QZChBliMzAbZhCmeA7Q66d0pVT1l610a5UPahN8FL2qm965urJdGdgqaKRrO2d11fozcGRk4fX51E_B-_3qbfkYrl8enpaLdahojGkooYEp00xLbhKZJDFT2ORKZzrWKUGM5URJxrjJY27o8C7nWZLkjCuseZ7n5BRc7-42rv7utG9Fab3SRSErXXdepJxzzFM-GG93RuVq7502onG2lK4XCIqRl9iIEYoYoYiRl5h4ie2wfDGldFmp8_3qBGjQryZdeiUL42SlrP9L4JimLB59dzvfjy10_48PxOJ5sUoIJb9Ul4h5</recordid><startdate>199008</startdate><enddate>199008</enddate><creator>ALI‐MELKKILÄ, T.</creator><creator>KAILA, T.</creator><creator>KANTO, J.</creator><creator>IISALO, E.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199008</creationdate><title>Pharmacokinetics of glycopyrronium in parturients</title><author>ALI‐MELKKILÄ, T. ; KAILA, T. ; KANTO, J. ; IISALO, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4524-a0f078e8ea9f6a6658c2fdcebe5e73188d3ca889fd59f404499b66d89c2e9ddd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Anesthesia, Obstetrical</topic><topic>Biological and medical sciences</topic><topic>Cesarean Section</topic><topic>Female</topic><topic>Fetal Blood - analysis</topic><topic>Genital system. Reproduction</topic><topic>Glycopyrrolate - blood</topic><topic>Glycopyrrolate - pharmacokinetics</topic><topic>Glycopyrrolate - pharmacology</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Injections, Intramuscular</topic><topic>Medical sciences</topic><topic>Parasympathetic nervous system; glycopyrronium</topic><topic>Pharmacokinetics</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnancy</topic><topic>Pyrrolidines - pharmacokinetics</topic><topic>Salivation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ALI‐MELKKILÄ, T.</creatorcontrib><creatorcontrib>KAILA, T.</creatorcontrib><creatorcontrib>KANTO, J.</creatorcontrib><creatorcontrib>IISALO, E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anaesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ALI‐MELKKILÄ, T.</au><au>KAILA, T.</au><au>KANTO, J.</au><au>IISALO, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of glycopyrronium in parturients</atitle><jtitle>Anaesthesia</jtitle><addtitle>Anaesthesia</addtitle><date>1990-08</date><risdate>1990</risdate><volume>45</volume><issue>8</issue><spage>634</spage><epage>637</epage><pages>634-637</pages><issn>0003-2409</issn><eissn>1365-2044</eissn><coden>ANASAB</coden><abstract>Summary
A sensitive radioreceptor assay was used to determine the pharmacokinetics of glycopyrronium 6 μg/kg after intramuscular (deltoid muscle) administration in eight Caesarean section patients. A fast absorption rate was found with a mean maximum plasma concentration (Cmax of 6.3 (SD 1.5) ng/ml, a mean time to Cmax (Tmax) of 10.0 (3.8) minutes and the elimination half‐life (Tl of 33.4 (1.92). The respective AUC0–8 h value was 5.61 (1.27) hours ng/ml. This dose produced a significant increase in the maternal heart rate after 10 minutes (p < 0.05) and an antisialogogue effect after 30 minutes (p < 0.05) of the drug injection. Almost half of drug (48.3%) was excreted into the urine within 3 hours. There were no measurable levels of glycopyrronium in the lumbar cerebrospinal fluid (CSF) after 60 minutes of drug injection. The concentrations of glycopyrronium in the umbilical venous (0.28 (0.25) ng/ml) and in the umbilical arterial (0.18 (0.11) ng/ml) plasma after 86 minutes of drug injection were low and clinically insignificant, as was the case in the amniotic fluid (0.15 (0.08) ng/ml).</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2400072</pmid><doi>10.1111/j.1365-2044.1990.tb14385.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Anaesthesia, 1990-08, Vol.45 (8), p.634-637 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Adult Anesthesia, Obstetrical Biological and medical sciences Cesarean Section Female Fetal Blood - analysis Genital system. Reproduction Glycopyrrolate - blood Glycopyrrolate - pharmacokinetics Glycopyrrolate - pharmacology Heart Rate - drug effects Humans Injections, Intramuscular Medical sciences Parasympathetic nervous system glycopyrronium Pharmacokinetics Pharmacology. Drug treatments Pregnancy Pyrrolidines - pharmacokinetics Salivation - drug effects |
| title | Pharmacokinetics of glycopyrronium in parturients |
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