Mechanisms of filtration of morphologically abnormal human sperm by cervical mucus
It is well known that cervical mucus restricts penetration of morphologically abnormal human sperm, both in vitro and in vivo. However, the mechanisms of such restriction are not well understood. Using videomicrography to simultaneously analyze the motions and morphology of individual human sperm, w...
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| Veröffentlicht in: | Fertility and sterility 1990-09, Vol.54 (3), p.513-516 |
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| container_title | Fertility and sterility |
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| creator | Katz, David F. Morales, Patricio Samuels, Steven J. Overstreet, James W. |
| description | It is well known that cervical mucus restricts penetration of morphologically abnormal human sperm, both in vitro and in vivo. However, the mechanisms of such restriction are not well understood. Using videomicrography to simultaneously analyze the motions and morphology of individual human sperm, we analyzed differential penetration of normal and abnormal sperm into fresh human cervical mucus. Abnormal sperm swam slower in mucus than the normal sperm, but their flagellar beat parameters were not commensurately different. Multivariate statistical analysis of the relationship between individual sperm velocity and flagellar beat parameters indicated that the heads of the abnormal sperm experienced greater resistance from the mucus than did normal heads. Differential mucus resistance, more than altered motile vigor, appears to be responsible for the restriction of abnormal sperm during migration through mucus. |
| doi_str_mv | 10.1016/S0015-0282(16)53772-8 |
| format | Article |
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However, the mechanisms of such restriction are not well understood. Using videomicrography to simultaneously analyze the motions and morphology of individual human sperm, we analyzed differential penetration of normal and abnormal sperm into fresh human cervical mucus. Abnormal sperm swam slower in mucus than the normal sperm, but their flagellar beat parameters were not commensurately different. Multivariate statistical analysis of the relationship between individual sperm velocity and flagellar beat parameters indicated that the heads of the abnormal sperm experienced greater resistance from the mucus than did normal heads. Differential mucus resistance, more than altered motile vigor, appears to be responsible for the restriction of abnormal sperm during migration through mucus.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)53772-8</identifier><identifier>PMID: 2397794</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Birth control ; Cervix Mucus - physiology ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Male ; Medical sciences ; Sperm Head - physiology ; Sperm Motility - physiology ; Sperm Tail - physiology ; Sperm-Ovum Interactions - physiology ; Spermatozoa - abnormalities ; Spermatozoa - physiology ; Sterility. 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However, the mechanisms of such restriction are not well understood. Using videomicrography to simultaneously analyze the motions and morphology of individual human sperm, we analyzed differential penetration of normal and abnormal sperm into fresh human cervical mucus. Abnormal sperm swam slower in mucus than the normal sperm, but their flagellar beat parameters were not commensurately different. Multivariate statistical analysis of the relationship between individual sperm velocity and flagellar beat parameters indicated that the heads of the abnormal sperm experienced greater resistance from the mucus than did normal heads. Differential mucus resistance, more than altered motile vigor, appears to be responsible for the restriction of abnormal sperm during migration through mucus.</description><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Cervix Mucus - physiology</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Sperm Head - physiology</subject><subject>Sperm Motility - physiology</subject><subject>Sperm Tail - physiology</subject><subject>Sperm-Ovum Interactions - physiology</subject><subject>Spermatozoa - abnormalities</subject><subject>Spermatozoa - physiology</subject><subject>Sterility. 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Andrology. Obstetrics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Sperm Head - physiology</topic><topic>Sperm Motility - physiology</topic><topic>Sperm Tail - physiology</topic><topic>Sperm-Ovum Interactions - physiology</topic><topic>Spermatozoa - abnormalities</topic><topic>Spermatozoa - physiology</topic><topic>Sterility. Assisted procreation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katz, David F.</creatorcontrib><creatorcontrib>Morales, Patricio</creatorcontrib><creatorcontrib>Samuels, Steven J.</creatorcontrib><creatorcontrib>Overstreet, James W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katz, David F.</au><au>Morales, Patricio</au><au>Samuels, Steven J.</au><au>Overstreet, James W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanisms of filtration of morphologically abnormal human sperm by cervical mucus</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1990-09-01</date><risdate>1990</risdate><volume>54</volume><issue>3</issue><spage>513</spage><epage>516</epage><pages>513-516</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>It is well known that cervical mucus restricts penetration of morphologically abnormal human sperm, both in vitro and in vivo. 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| ispartof | Fertility and sterility, 1990-09, Vol.54 (3), p.513-516 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Birth control Cervix Mucus - physiology Female Gynecology. Andrology. Obstetrics Humans Male Medical sciences Sperm Head - physiology Sperm Motility - physiology Sperm Tail - physiology Sperm-Ovum Interactions - physiology Spermatozoa - abnormalities Spermatozoa - physiology Sterility. Assisted procreation |
| title | Mechanisms of filtration of morphologically abnormal human sperm by cervical mucus |
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