5-HT2 and D2 Receptor Occupancy of Olanzapine in Schizophrenia: A PET Investigation

OBJECTIVE: Olanzapine is a new atypical antipsychotic recently introduced for the treatment of schizophrenia. The purpose of this study was to investigate olanzapine's binding to the serotonin 5-HT2 and dopamine D2 receptors in schizophrenic patients being treated with clinically relevant doses...

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Veröffentlicht in:	The American journal of psychiatry 1998-07, Vol.155 (7), p.921-928
Hauptverfasser:	Kapur, Shitij, Zipursky, Robert B., Remington, Gary, Jones, Corey, DaSilva, Jean, Wilson, Alan A., Houle, Sylvain
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antipsychotic Agents - pharmacokinetics Antipsychotic Agents - therapeutic use Benzodiazepines Biological and medical sciences Carbon Radioisotopes Dose-Response Relationship, Drug Drug Administration Schedule Drug therapy Female Fluorine Radioisotopes Humans Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Pirenzepine - analogs & derivatives Pirenzepine - pharmacokinetics Pirenzepine - therapeutic use Prolactin - blood Psychiatry Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Pyrimidinones Raclopride Receptors, Dopamine D2 - drug effects Receptors, Dopamine D2 - metabolism Receptors, Serotonin - drug effects Receptors, Serotonin - metabolism Salicylamides Schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - drug therapy Schizophrenia - metabolism Tomography, Emission-Computed Treatment Outcome
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