Mapping of distinct serologic and T cell recognition epitopes on an HLA- DR beta-chain
A new DR beta-chain allele is defined that is identical to the previously described DR6b molecule except for the first hyperpolymorphic region, where the new allele displays the same polymorphisms found on DR8 and DR12 genes. Two distinct epitopes have been mapped on this new allele. The polymorphis...
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| Veröffentlicht in: | The Journal of immunology (1950) 1990-10, Vol.145 (7), p.2020-2024 |
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| container_issue | 7 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 145 |
| creator | Gorski, J Radka, SF Masewicz, S Mickelson, EM |
| description | A new DR beta-chain allele is defined that is identical to the previously described DR6b molecule except for the first hyperpolymorphic region, where the new allele displays the same polymorphisms found on DR8 and DR12 genes. Two distinct epitopes have been mapped on this new allele. The polymorphism in common with DRw8 and DRw12 is recognized by mAb GS313-9D11. However, alloreactive T cell clones specific for DR6b cells (Dw9) recognize this allele, whereas Dw8-specific T cell clones do not. The mAb determinant maps to the first beta-sheet and probably involves a polymorphic residue lying outside the helix. The binding of mAb 9D11 to this region does not interfere with TCR binding. Alloreactive T cell recognition is associated with polymorphisms located predominantly on the alpha-helical portion of the molecule. |
| doi_str_mv | 10.4049/jimmunol.145.7.2020 |
| format | Article |
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Two distinct epitopes have been mapped on this new allele. The polymorphism in common with DRw8 and DRw12 is recognized by mAb GS313-9D11. However, alloreactive T cell clones specific for DR6b cells (Dw9) recognize this allele, whereas Dw8-specific T cell clones do not. The mAb determinant maps to the first beta-sheet and probably involves a polymorphic residue lying outside the helix. The binding of mAb 9D11 to this region does not interfere with TCR binding. Alloreactive T cell recognition is associated with polymorphisms located predominantly on the alpha-helical portion of the molecule.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.145.7.2020</identifier><identifier>PMID: 1697874</identifier><identifier>CODEN: JOIMA3</identifier><language>eng</language><publisher>Bethesda, MD: Am Assoc Immnol</publisher><subject>Alleles ; Amino Acid Sequence ; Antibodies, Monoclonal - immunology ; Antigenic determinants, haptens, artificial antigens ; Antigens ; Base Sequence ; Biological and medical sciences ; Epitopes ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; HLA-DR Antigens - genetics ; HLA-DR Antigens - immunology ; Humans ; Isoantibodies - immunology ; Models, Molecular ; Molecular immunology ; Molecular Sequence Data ; Oligonucleotides ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Protein Conformation ; T-Lymphocytes - immunology</subject><ispartof>The Journal of immunology (1950), 1990-10, Vol.145 (7), p.2020-2024</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-a19f1821762c222893a12ffcc6ca842d57442c807e34c4024b0ebae522ecb1bf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4516953$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1697874$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gorski, J</creatorcontrib><creatorcontrib>Radka, SF</creatorcontrib><creatorcontrib>Masewicz, S</creatorcontrib><creatorcontrib>Mickelson, EM</creatorcontrib><title>Mapping of distinct serologic and T cell recognition epitopes on an HLA- DR beta-chain</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>A new DR beta-chain allele is defined that is identical to the previously described DR6b molecule except for the first hyperpolymorphic region, where the new allele displays the same polymorphisms found on DR8 and DR12 genes. Two distinct epitopes have been mapped on this new allele. The polymorphism in common with DRw8 and DRw12 is recognized by mAb GS313-9D11. However, alloreactive T cell clones specific for DR6b cells (Dw9) recognize this allele, whereas Dw8-specific T cell clones do not. The mAb determinant maps to the first beta-sheet and probably involves a polymorphic residue lying outside the helix. The binding of mAb 9D11 to this region does not interfere with TCR binding. Alloreactive T cell recognition is associated with polymorphisms located predominantly on the alpha-helical portion of the molecule.</description><subject>Alleles</subject><subject>Amino Acid Sequence</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antigenic determinants, haptens, artificial antigens</subject><subject>Antigens</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Epitopes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>HLA-DR Antigens - genetics</subject><subject>HLA-DR Antigens - immunology</subject><subject>Humans</subject><subject>Isoantibodies - immunology</subject><subject>Models, Molecular</subject><subject>Molecular immunology</subject><subject>Molecular Sequence Data</subject><subject>Oligonucleotides</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Protein Conformation</subject><subject>T-Lymphocytes - immunology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKxDAUhoMoOl6eQIQsRFcdT9I0aZfiHUYEUbchzaQzkTapSYfBtzfDjJedqxw43_nz8yF0TGDMgFUX77brFs63Y8KKsRhToLCFRqQoIOMc-DYaAVCaEcHFHtqP8R0AOFC2i3YJr0Qp2Ai9Paq-t26GfYOnNg7W6QFHE3zrZ1Zj5ab4BWvTtjgY7WfODtY7bHo7-N5EnGbl8P3kMsPXz7g2g8r0XFl3iHYa1UZztHkP0OvtzcvVfTZ5unu4upxkmuViyBSpGlLS1JBqSmlZ5YrQptGaa1UyOi0EY1SXIEzONEvVazC1MgWlRtekbvIDdLbO7YP_WJg4yM7GVV3ljF9EKaqqAlaQf0HCCSkhLxKYr0EdfIzBNLIPtlPhUxKQK-3yW7tM2qWQK-3p6mQTv6g7M_29WXtO-9PNXkWt2iYop238wVJDXhV5ws7X2NzO5ksbjIydatsUSuRyufzz4RciKpkv</recordid><startdate>19901001</startdate><enddate>19901001</enddate><creator>Gorski, J</creator><creator>Radka, SF</creator><creator>Masewicz, S</creator><creator>Mickelson, EM</creator><general>Am Assoc Immnol</general><general>American Association of Immunologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19901001</creationdate><title>Mapping of distinct serologic and T cell recognition epitopes on an HLA- DR beta-chain</title><author>Gorski, J ; Radka, SF ; Masewicz, S ; Mickelson, EM</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-a19f1821762c222893a12ffcc6ca842d57442c807e34c4024b0ebae522ecb1bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Alleles</topic><topic>Amino Acid Sequence</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antigenic determinants, haptens, artificial antigens</topic><topic>Antigens</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Epitopes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>HLA-DR Antigens - genetics</topic><topic>HLA-DR Antigens - immunology</topic><topic>Humans</topic><topic>Isoantibodies - immunology</topic><topic>Models, Molecular</topic><topic>Molecular immunology</topic><topic>Molecular Sequence Data</topic><topic>Oligonucleotides</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Protein Conformation</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gorski, J</creatorcontrib><creatorcontrib>Radka, SF</creatorcontrib><creatorcontrib>Masewicz, S</creatorcontrib><creatorcontrib>Mickelson, EM</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gorski, J</au><au>Radka, SF</au><au>Masewicz, S</au><au>Mickelson, EM</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mapping of distinct serologic and T cell recognition epitopes on an HLA- DR beta-chain</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1990-10-01</date><risdate>1990</risdate><volume>145</volume><issue>7</issue><spage>2020</spage><epage>2024</epage><pages>2020-2024</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><coden>JOIMA3</coden><abstract>A new DR beta-chain allele is defined that is identical to the previously described DR6b molecule except for the first hyperpolymorphic region, where the new allele displays the same polymorphisms found on DR8 and DR12 genes. Two distinct epitopes have been mapped on this new allele. The polymorphism in common with DRw8 and DRw12 is recognized by mAb GS313-9D11. However, alloreactive T cell clones specific for DR6b cells (Dw9) recognize this allele, whereas Dw8-specific T cell clones do not. The mAb determinant maps to the first beta-sheet and probably involves a polymorphic residue lying outside the helix. The binding of mAb 9D11 to this region does not interfere with TCR binding. Alloreactive T cell recognition is associated with polymorphisms located predominantly on the alpha-helical portion of the molecule.</abstract><cop>Bethesda, MD</cop><pub>Am Assoc Immnol</pub><pmid>1697874</pmid><doi>10.4049/jimmunol.145.7.2020</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alleles Amino Acid Sequence Antibodies, Monoclonal - immunology Antigenic determinants, haptens, artificial antigens Antigens Base Sequence Biological and medical sciences Epitopes Fundamental and applied biological sciences. Psychology Fundamental immunology HLA-DR Antigens - genetics HLA-DR Antigens - immunology Humans Isoantibodies - immunology Models, Molecular Molecular immunology Molecular Sequence Data Oligonucleotides Polymerase Chain Reaction Polymorphism, Genetic Protein Conformation T-Lymphocytes - immunology |
| title | Mapping of distinct serologic and T cell recognition epitopes on an HLA- DR beta-chain |
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