Germline V genes encode viable motheaten mouse autoantibodies against thymocytes and red blood cells

Autoantibodies against thymocytes and RBC may contribute to the pathophysiology of homozygous viable motheaten (mev) autoimmune disease. Whether the production of these autoantibodies in mev mouse results from polyclonal nonspecific B cell activation or specific Ag-driven stimulation is not known. T...

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Veröffentlicht in:	The Journal of immunology (1950) 1990-10, Vol.145 (7), p.2304-2311
Hauptverfasser:	Kasturi, KN, Mayer, R, Bona, CA, Scott, VE, Sidman, CL
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Ly - analysis Autoantibodies - genetics B-Lymphocytes - physiology Base Sequence Blotting, Northern Blotting, Southern Erythrocytes - immunology Genes, Immunoglobulin Immunoglobulin Heavy Chains - genetics Immunoglobulin kappa-Chains - genetics Immunoglobulin Variable Region - genetics Lymphocyte Activation Mice Mice, Mutant Strains - genetics Molecular Sequence Data Oligonucleotide Probes Polymerase Chain Reaction Thymus Gland - immunology
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