99mTc-HL91 : Hot spot detection of ischemic myocardium in vivo by gamma camera imaging
99mTc-HL91 is a new hypoxia imaging agent that demonstrates increased uptake and retention in globally hypoxic myocardium in vitro. The purpose of this study was to determine whether 99mTc-HL91 could detect regional ischemia in vivo by gamma camera imaging. Eight open-chest dogs with left circumflex...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1998-06, Vol.97 (25), p.2557-2566 |
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| container_title | Circulation (New York, N.Y.) |
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| creator | OKADA, R. D JOHNSON, G. III NGUYEN, K. N ZHONGLIN LIU EDWARDS, B ARCHER, C. M NORTH, T. L KING, A. C KELLY, J. D |
| description | 99mTc-HL91 is a new hypoxia imaging agent that demonstrates increased uptake and retention in globally hypoxic myocardium in vitro. The purpose of this study was to determine whether 99mTc-HL91 could detect regional ischemia in vivo by gamma camera imaging.
Eight open-chest dogs with left circumflex (LCx) stenoses were studied. Injection of 5 mCi of 99mTc-HL91 and microspheres was followed by imaging over 4 hours. Heart slices were imaged, then stained with triphenyltetrazolium chloride (TTC), and tissues were well-counted. TTC staining demonstrated no injury. Mean LCx blood flow was 0.32+/-0.04 mL x min(-1) x g(-1), and mean left anterior descending coronary artery (LAD) flow was 0.96+/-0.02 mL x min(-1) x g(-1) (ratio, 0.33). "Hot spots" were detected in 8 of 8 experiments in vivo within 60 minutes and improved over 4 hours. Region of interest analysis of LCx/LAD activity ratios demonstrated significant increases within 30 minutes (final ratio, 3.0; P |
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Eight open-chest dogs with left circumflex (LCx) stenoses were studied. Injection of 5 mCi of 99mTc-HL91 and microspheres was followed by imaging over 4 hours. Heart slices were imaged, then stained with triphenyltetrazolium chloride (TTC), and tissues were well-counted. TTC staining demonstrated no injury. Mean LCx blood flow was 0.32+/-0.04 mL x min(-1) x g(-1), and mean left anterior descending coronary artery (LAD) flow was 0.96+/-0.02 mL x min(-1) x g(-1) (ratio, 0.33). "Hot spots" were detected in 8 of 8 experiments in vivo within 60 minutes and improved over 4 hours. Region of interest analysis of LCx/LAD activity ratios demonstrated significant increases within 30 minutes (final ratio, 3.0; P<0.05). LCx and LAD washout curves demonstrated significant differences within 15 minutes. Washout curves were biexponential over 1 hour, followed by linear retention from 1 to 4 hours. Four-hour fractional retention was 0.12 for LAD and 0.44 for LCx (P<0.01). Myocardial flow versus tracer uptake demonstrated 2 phases: phase 1 (flow, 0.05 to 0.7 mL x min(-1) x g(-1)) had an inverse linear correlation (r= -0.80); phase 2, (flow, >0.7 mL x min(-1) x g(-1)) had no correlation. Ischemic heart/liver ratios remained near 1.0 for 4 hours.
99mTc-HL91 positively identifies regional myocardial ischemia in a canine model using 99mTc imaging. Quantitative techniques allowed identification of ischemic myocardium within 15 minutes of tracer administration.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>PMID: 9657477</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Biological and medical sciences ; Cardiology. Vascular system ; Contrast Media ; Coronary heart disease ; Dogs ; Gamma Cameras ; Heart ; Medical sciences ; Myocardial Ischemia - diagnosis ; Organotechnetium Compounds ; Oximes ; Radiopharmaceuticals</subject><ispartof>Circulation (New York, N.Y.), 1998-06, Vol.97 (25), p.2557-2566</ispartof><rights>1998 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Jun 30, 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2313544$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9657477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OKADA, R. D</creatorcontrib><creatorcontrib>JOHNSON, G. III</creatorcontrib><creatorcontrib>NGUYEN, K. N</creatorcontrib><creatorcontrib>ZHONGLIN LIU</creatorcontrib><creatorcontrib>EDWARDS, B</creatorcontrib><creatorcontrib>ARCHER, C. M</creatorcontrib><creatorcontrib>NORTH, T. L</creatorcontrib><creatorcontrib>KING, A. C</creatorcontrib><creatorcontrib>KELLY, J. D</creatorcontrib><title>99mTc-HL91 : Hot spot detection of ischemic myocardium in vivo by gamma camera imaging</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>99mTc-HL91 is a new hypoxia imaging agent that demonstrates increased uptake and retention in globally hypoxic myocardium in vitro. The purpose of this study was to determine whether 99mTc-HL91 could detect regional ischemia in vivo by gamma camera imaging.
Eight open-chest dogs with left circumflex (LCx) stenoses were studied. Injection of 5 mCi of 99mTc-HL91 and microspheres was followed by imaging over 4 hours. Heart slices were imaged, then stained with triphenyltetrazolium chloride (TTC), and tissues were well-counted. TTC staining demonstrated no injury. Mean LCx blood flow was 0.32+/-0.04 mL x min(-1) x g(-1), and mean left anterior descending coronary artery (LAD) flow was 0.96+/-0.02 mL x min(-1) x g(-1) (ratio, 0.33). "Hot spots" were detected in 8 of 8 experiments in vivo within 60 minutes and improved over 4 hours. Region of interest analysis of LCx/LAD activity ratios demonstrated significant increases within 30 minutes (final ratio, 3.0; P<0.05). LCx and LAD washout curves demonstrated significant differences within 15 minutes. Washout curves were biexponential over 1 hour, followed by linear retention from 1 to 4 hours. Four-hour fractional retention was 0.12 for LAD and 0.44 for LCx (P<0.01). Myocardial flow versus tracer uptake demonstrated 2 phases: phase 1 (flow, 0.05 to 0.7 mL x min(-1) x g(-1)) had an inverse linear correlation (r= -0.80); phase 2, (flow, >0.7 mL x min(-1) x g(-1)) had no correlation. Ischemic heart/liver ratios remained near 1.0 for 4 hours.
99mTc-HL91 positively identifies regional myocardial ischemia in a canine model using 99mTc imaging. Quantitative techniques allowed identification of ischemic myocardium within 15 minutes of tracer administration.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Contrast Media</subject><subject>Coronary heart disease</subject><subject>Dogs</subject><subject>Gamma Cameras</subject><subject>Heart</subject><subject>Medical sciences</subject><subject>Myocardial Ischemia - diagnosis</subject><subject>Organotechnetium Compounds</subject><subject>Oximes</subject><subject>Radiopharmaceuticals</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE9LAzEQxYMotVY_ghBEvC3kz6bJeJNirVDwUr0u2TRpUzabutkt9NsbcPHgZYbh_Xi8eRdoSgUri1JwuERTQggUkjN2jW5SOuRzzqWYoAnMhSylnKIvgLAxxWoNFD_jVexxOuaxtb01vY8tjg77ZPY2eIPDORrdbf0QsG_xyZ8irs94p0PQ2OhgO4190Dvf7m7RldNNsnfjnqHP5etmsSrWH2_vi5d1saeCykI4ZZ001JnSslqIWhKunRHKSqoNcMqBcKqUAmHBGAqKCUdcbaXgpQLJZ-jp1_fYxe_Bpr4KOa1tGt3aOKRKAigg2XWGHv6Bhzh0bc5WMcokzXWwDN2P0FAHu62OXX6nO1djW1l_HHWdjG5cp1vj0x_Gcl5RlvwHCx1w8Q</recordid><startdate>19980630</startdate><enddate>19980630</enddate><creator>OKADA, R. D</creator><creator>JOHNSON, G. III</creator><creator>NGUYEN, K. N</creator><creator>ZHONGLIN LIU</creator><creator>EDWARDS, B</creator><creator>ARCHER, C. M</creator><creator>NORTH, T. L</creator><creator>KING, A. C</creator><creator>KELLY, J. D</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>19980630</creationdate><title>99mTc-HL91 : Hot spot detection of ischemic myocardium in vivo by gamma camera imaging</title><author>OKADA, R. D ; JOHNSON, G. III ; NGUYEN, K. N ; ZHONGLIN LIU ; EDWARDS, B ; ARCHER, C. M ; NORTH, T. L ; KING, A. C ; KELLY, J. D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h1517-5f8ef7c1fc4e2b55b703afc58e71ac9313903188895e9cc19825f0fbe75348973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Contrast Media</topic><topic>Coronary heart disease</topic><topic>Dogs</topic><topic>Gamma Cameras</topic><topic>Heart</topic><topic>Medical sciences</topic><topic>Myocardial Ischemia - diagnosis</topic><topic>Organotechnetium Compounds</topic><topic>Oximes</topic><topic>Radiopharmaceuticals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OKADA, R. D</creatorcontrib><creatorcontrib>JOHNSON, G. III</creatorcontrib><creatorcontrib>NGUYEN, K. N</creatorcontrib><creatorcontrib>ZHONGLIN LIU</creatorcontrib><creatorcontrib>EDWARDS, B</creatorcontrib><creatorcontrib>ARCHER, C. M</creatorcontrib><creatorcontrib>NORTH, T. L</creatorcontrib><creatorcontrib>KING, A. C</creatorcontrib><creatorcontrib>KELLY, J. D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OKADA, R. D</au><au>JOHNSON, G. III</au><au>NGUYEN, K. N</au><au>ZHONGLIN LIU</au><au>EDWARDS, B</au><au>ARCHER, C. M</au><au>NORTH, T. L</au><au>KING, A. C</au><au>KELLY, J. D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>99mTc-HL91 : Hot spot detection of ischemic myocardium in vivo by gamma camera imaging</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>1998-06-30</date><risdate>1998</risdate><volume>97</volume><issue>25</issue><spage>2557</spage><epage>2566</epage><pages>2557-2566</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>99mTc-HL91 is a new hypoxia imaging agent that demonstrates increased uptake and retention in globally hypoxic myocardium in vitro. The purpose of this study was to determine whether 99mTc-HL91 could detect regional ischemia in vivo by gamma camera imaging.
Eight open-chest dogs with left circumflex (LCx) stenoses were studied. Injection of 5 mCi of 99mTc-HL91 and microspheres was followed by imaging over 4 hours. Heart slices were imaged, then stained with triphenyltetrazolium chloride (TTC), and tissues were well-counted. TTC staining demonstrated no injury. Mean LCx blood flow was 0.32+/-0.04 mL x min(-1) x g(-1), and mean left anterior descending coronary artery (LAD) flow was 0.96+/-0.02 mL x min(-1) x g(-1) (ratio, 0.33). "Hot spots" were detected in 8 of 8 experiments in vivo within 60 minutes and improved over 4 hours. Region of interest analysis of LCx/LAD activity ratios demonstrated significant increases within 30 minutes (final ratio, 3.0; P<0.05). LCx and LAD washout curves demonstrated significant differences within 15 minutes. Washout curves were biexponential over 1 hour, followed by linear retention from 1 to 4 hours. Four-hour fractional retention was 0.12 for LAD and 0.44 for LCx (P<0.01). Myocardial flow versus tracer uptake demonstrated 2 phases: phase 1 (flow, 0.05 to 0.7 mL x min(-1) x g(-1)) had an inverse linear correlation (r= -0.80); phase 2, (flow, >0.7 mL x min(-1) x g(-1)) had no correlation. Ischemic heart/liver ratios remained near 1.0 for 4 hours.
99mTc-HL91 positively identifies regional myocardial ischemia in a canine model using 99mTc imaging. Quantitative techniques allowed identification of ischemic myocardium within 15 minutes of tracer administration.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>9657477</pmid><tpages>10</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Cardiology. Vascular system Contrast Media Coronary heart disease Dogs Gamma Cameras Heart Medical sciences Myocardial Ischemia - diagnosis Organotechnetium Compounds Oximes Radiopharmaceuticals |
| title | 99mTc-HL91 : Hot spot detection of ischemic myocardium in vivo by gamma camera imaging |
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