Relative Frequency of Upper Gastrointestinal and Colonic Lesions in Patients with Positive Fecal Occult-Blood Tests
When used to screen large populations, guaiac-based fecal occult-blood tests have been shown to prevent death from colorectal cancer. 1 – 3 Nonetheless, drawbacks associated with their use remain, including a high rate of false positive tests (i.e., a lack of specificity), 4 – 6 which can lead to fu...
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| Veröffentlicht in: | The New England journal of medicine 1998-07, Vol.339 (3), p.153-159 |
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| container_title | The New England journal of medicine |
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| creator | Rockey, Don C Koch, Johannes Cello, John P Sanders, Linda L McQuaid, Kenneth |
| description | When used to screen large populations, guaiac-based fecal occult-blood tests have been shown to prevent death from colorectal cancer.
1
–
3
Nonetheless, drawbacks associated with their use remain, including a high rate of false positive tests (i.e., a lack of specificity),
4
–
6
which can lead to further testing and expense.
5
,
7
,
8
Bleeding lesions anywhere in the gastrointestinal tract may produce positive results on guaiac-based fecal occult-blood tests. Guaiac-based tests are thought to be unreliable for the detection of occult bleeding from the upper gastrointestinal tract because hemoglobin (or heme), which is the component in blood that causes a positive reaction, . . . |
| doi_str_mv | 10.1056/NEJM199807163390303 |
| format | Article |
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1
–
3
Nonetheless, drawbacks associated with their use remain, including a high rate of false positive tests (i.e., a lack of specificity),
4
–
6
which can lead to further testing and expense.
5
,
7
,
8
Bleeding lesions anywhere in the gastrointestinal tract may produce positive results on guaiac-based fecal occult-blood tests. Guaiac-based tests are thought to be unreliable for the detection of occult bleeding from the upper gastrointestinal tract because hemoglobin (or heme), which is the component in blood that causes a positive reaction, . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199807163390303</identifier><identifier>PMID: 9664091</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Aged ; Biological and medical sciences ; Colonic Diseases - diagnosis ; Colonic Diseases - epidemiology ; Colorectal cancer ; Endoscopy, Digestive System ; False Positive Reactions ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrointestinal diseases ; Gastrointestinal Diseases - diagnosis ; Gastrointestinal Diseases - epidemiology ; Humans ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Occult Blood ; Other diseases. Semiology ; Prevalence ; Prospective Studies ; Sensitivity and Specificity ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><ispartof>The New England journal of medicine, 1998-07, Vol.339 (3), p.153-159</ispartof><rights>Copyright © 1998 Massachusetts Medical Society. All rights reserved.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c524t-88f22c71d784971dfc953013a2f2bf5c1a5a2cf58ed17a0d549e1ce42b88c0913</citedby><cites>FETCH-LOGICAL-c524t-88f22c71d784971dfc953013a2f2bf5c1a5a2cf58ed17a0d549e1ce42b88c0913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199807163390303$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199807163390303$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2312676$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9664091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rockey, Don C</creatorcontrib><creatorcontrib>Koch, Johannes</creatorcontrib><creatorcontrib>Cello, John P</creatorcontrib><creatorcontrib>Sanders, Linda L</creatorcontrib><creatorcontrib>McQuaid, Kenneth</creatorcontrib><title>Relative Frequency of Upper Gastrointestinal and Colonic Lesions in Patients with Positive Fecal Occult-Blood Tests</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>When used to screen large populations, guaiac-based fecal occult-blood tests have been shown to prevent death from colorectal cancer.
1
–
3
Nonetheless, drawbacks associated with their use remain, including a high rate of false positive tests (i.e., a lack of specificity),
4
–
6
which can lead to further testing and expense.
5
,
7
,
8
Bleeding lesions anywhere in the gastrointestinal tract may produce positive results on guaiac-based fecal occult-blood tests. Guaiac-based tests are thought to be unreliable for the detection of occult bleeding from the upper gastrointestinal tract because hemoglobin (or heme), which is the component in blood that causes a positive reaction, . . .</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Colonic Diseases - diagnosis</subject><subject>Colonic Diseases - epidemiology</subject><subject>Colorectal cancer</subject><subject>Endoscopy, Digestive System</subject><subject>False Positive Reactions</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastrointestinal diseases</subject><subject>Gastrointestinal Diseases - diagnosis</subject><subject>Gastrointestinal Diseases - epidemiology</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Occult Blood</subject><subject>Other diseases. Semiology</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Liver. Pancreas. Abdomen</topic><topic>Gastrointestinal diseases</topic><topic>Gastrointestinal Diseases - diagnosis</topic><topic>Gastrointestinal Diseases - epidemiology</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Occult Blood</topic><topic>Other diseases. Semiology</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. 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1
–
3
Nonetheless, drawbacks associated with their use remain, including a high rate of false positive tests (i.e., a lack of specificity),
4
–
6
which can lead to further testing and expense.
5
,
7
,
8
Bleeding lesions anywhere in the gastrointestinal tract may produce positive results on guaiac-based fecal occult-blood tests. Guaiac-based tests are thought to be unreliable for the detection of occult bleeding from the upper gastrointestinal tract because hemoglobin (or heme), which is the component in blood that causes a positive reaction, . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>9664091</pmid><doi>10.1056/NEJM199807163390303</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 1998-07, Vol.339 (3), p.153-159 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Aged Biological and medical sciences Colonic Diseases - diagnosis Colonic Diseases - epidemiology Colorectal cancer Endoscopy, Digestive System False Positive Reactions Female Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal diseases Gastrointestinal Diseases - diagnosis Gastrointestinal Diseases - epidemiology Humans Logistic Models Male Medical sciences Middle Aged Occult Blood Other diseases. Semiology Prevalence Prospective Studies Sensitivity and Specificity Stomach. Duodenum. Small intestine. Colon. Rectum. Anus |
| title | Relative Frequency of Upper Gastrointestinal and Colonic Lesions in Patients with Positive Fecal Occult-Blood Tests |
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