Normotensive Offspring with Non-Dipper Hypertensive Parents Have Abnormal Sleep Pattern
The objective of this study was to determine whether abnormal microstructure of sleep in non-dipper hypertensive patients was present in their offspring. Subjects included 11 normotensive offspring of non-dipper hypertensive parents (FH + ND), 6 of dipper hypertensive parents (FH + D) and 5 of normo...
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Veröffentlicht in: | Blood pressure 1998-05, Vol.7 (2), p.76-80 |
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description | The objective of this study was to determine whether abnormal microstructure of sleep in non-dipper hypertensive patients was present in their offspring. Subjects included 11 normotensive offspring of non-dipper hypertensive parents (FH + ND), 6 of dipper hypertensive parents (FH + D) and 5 of normotensive parents (Controls). We measured blood pressure beat-to-beat by Finapres and all stages of sleep by polysomnographically recording simultaneously during spontaneous nocturnal sleep. We analysed blood pressure pattern for 4-min long random periods while the subjects were awake and during all stages of sleep; sleep efficiency (SE), sleep latency (SL), delta-sleep latency (delta-SL), REM sleep latency (REM-SL), Stage 1, Stage 2, Stage 3, Stage 4 and REM duration and percentage values, and microstructural aspects of sleep (arousal and microarousal temporization and features). FH + D and controls showed a fall in blood pressure greater than 10% in all stages of NREM sleep and in the FH + ND blood pressure fall in less than 10% of waking values in all NREM stages. REM sleep and heart rate were similar in the three groups during all stages of sleep. FH + ND showed the same number of arousals but more microarousals than FH + D and controls (p < 0.0001). Microarousals induced several stage shifts through lighter sleep. For this reason, FH + ND spent more time in stage 2 than FH + D and controls. In conclusion, offspring of non-dipper hypertension parents showed a greater number of microarousals than the other two groups. |
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Subjects included 11 normotensive offspring of non-dipper hypertensive parents (FH + ND), 6 of dipper hypertensive parents (FH + D) and 5 of normotensive parents (Controls). We measured blood pressure beat-to-beat by Finapres and all stages of sleep by polysomnographically recording simultaneously during spontaneous nocturnal sleep. We analysed blood pressure pattern for 4-min long random periods while the subjects were awake and during all stages of sleep; sleep efficiency (SE), sleep latency (SL), delta-sleep latency (delta-SL), REM sleep latency (REM-SL), Stage 1, Stage 2, Stage 3, Stage 4 and REM duration and percentage values, and microstructural aspects of sleep (arousal and microarousal temporization and features). FH + D and controls showed a fall in blood pressure greater than 10% in all stages of NREM sleep and in the FH + ND blood pressure fall in less than 10% of waking values in all NREM stages. REM sleep and heart rate were similar in the three groups during all stages of sleep. FH + ND showed the same number of arousals but more microarousals than FH + D and controls (p < 0.0001). Microarousals induced several stage shifts through lighter sleep. For this reason, FH + ND spent more time in stage 2 than FH + D and controls. In conclusion, offspring of non-dipper hypertension parents showed a greater number of microarousals than the other two groups.</description><identifier>ISSN: 0803-7051</identifier><identifier>EISSN: 1651-1999</identifier><identifier>DOI: 10.1080/080370598437439</identifier><identifier>PMID: 9657533</identifier><language>eng</language><publisher>Stockholm: Informa UK Ltd</publisher><subject>Adult ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - physiology ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Humans ; Hypertension - genetics ; Hypertension - physiopathology ; Male ; Medical sciences ; Sleep - physiology</subject><ispartof>Blood pressure, 1998-05, Vol.7 (2), p.76-80</ispartof><rights>1998 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3789-f5ed89d532be5fb28ba7af4ed31f0eeaac9380d0d1ba716522c0204a4b5993873</citedby><cites>FETCH-LOGICAL-c3789-f5ed89d532be5fb28ba7af4ed31f0eeaac9380d0d1ba716522c0204a4b5993873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/080370598437439$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/080370598437439$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>315,781,785,27926,27927,59649,60438,61223,61404</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2266625$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9657533$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FRISINA, N</creatorcontrib><creatorcontrib>PEDULLA, M</creatorcontrib><creatorcontrib>MENTO, G</creatorcontrib><creatorcontrib>MORANO, E</creatorcontrib><creatorcontrib>LANUZZA, B</creatorcontrib><creatorcontrib>BUEMI, M</creatorcontrib><title>Normotensive Offspring with Non-Dipper Hypertensive Parents Have Abnormal Sleep Pattern</title><title>Blood pressure</title><addtitle>Blood Press</addtitle><description>The objective of this study was to determine whether abnormal microstructure of sleep in non-dipper hypertensive patients was present in their offspring. Subjects included 11 normotensive offspring of non-dipper hypertensive parents (FH + ND), 6 of dipper hypertensive parents (FH + D) and 5 of normotensive parents (Controls). We measured blood pressure beat-to-beat by Finapres and all stages of sleep by polysomnographically recording simultaneously during spontaneous nocturnal sleep. We analysed blood pressure pattern for 4-min long random periods while the subjects were awake and during all stages of sleep; sleep efficiency (SE), sleep latency (SL), delta-sleep latency (delta-SL), REM sleep latency (REM-SL), Stage 1, Stage 2, Stage 3, Stage 4 and REM duration and percentage values, and microstructural aspects of sleep (arousal and microarousal temporization and features). FH + D and controls showed a fall in blood pressure greater than 10% in all stages of NREM sleep and in the FH + ND blood pressure fall in less than 10% of waking values in all NREM stages. REM sleep and heart rate were similar in the three groups during all stages of sleep. FH + ND showed the same number of arousals but more microarousals than FH + D and controls (p < 0.0001). Microarousals induced several stage shifts through lighter sleep. For this reason, FH + ND spent more time in stage 2 than FH + D and controls. In conclusion, offspring of non-dipper hypertension parents showed a greater number of microarousals than the other two groups.</description><subject>Adult</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - physiology</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Humans</subject><subject>Hypertension - genetics</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Sleep - physiology</subject><issn>0803-7051</issn><issn>1651-1999</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM9LwzAUx4Moc07PnoQexFtd0jRt4m34a4JsgorHkrYvrpIlNemU_fdmbBMUdkhC-Hzf9733ReiU4EuCOR6GQ3PMBE9pnlKxh_okYyQmQoh91F_ROGByiI68_8CYUIpxD_VExnJGaR-9Tayb2w6Mb74gmirlW9eY9-i76WbRxJr4pmlbcNF4Ge6t7Ek6MJ2PxjJ8RqUJFlJHzxqgDazrwJljdKCk9nCyeQfo9e725XocP07vH65Hj3FFcy5ixaDmomY0KYGpMuGlzKVKoaZEYQApK0E5rnFNAgibJUmFE5zKtGQikJwO0MXat3X2cwG-K-aNr0BracAufJELwXPOWRAO18LKWe8dqCIsOpduWRBcrKIs_kUZKs421otyDvWvfpNd4OcbLn0ltXLSVI3_lSVJlmXJqvHVWtYYtQrq2zpdF51cauu2NXT3DOJP8Qyk7mZVyL_4sAtnQrQ75_8BYougRQ</recordid><startdate>199805</startdate><enddate>199805</enddate><creator>FRISINA, N</creator><creator>PEDULLA, M</creator><creator>MENTO, G</creator><creator>MORANO, E</creator><creator>LANUZZA, B</creator><creator>BUEMI, M</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199805</creationdate><title>Normotensive Offspring with Non-Dipper Hypertensive Parents Have Abnormal Sleep Pattern</title><author>FRISINA, N ; PEDULLA, M ; MENTO, G ; MORANO, E ; LANUZZA, B ; BUEMI, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3789-f5ed89d532be5fb28ba7af4ed31f0eeaac9380d0d1ba716522c0204a4b5993873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - physiology</topic><topic>Cardiology. Vascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Humans</topic><topic>Hypertension - genetics</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Sleep - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FRISINA, N</creatorcontrib><creatorcontrib>PEDULLA, M</creatorcontrib><creatorcontrib>MENTO, G</creatorcontrib><creatorcontrib>MORANO, E</creatorcontrib><creatorcontrib>LANUZZA, B</creatorcontrib><creatorcontrib>BUEMI, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood pressure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FRISINA, N</au><au>PEDULLA, M</au><au>MENTO, G</au><au>MORANO, E</au><au>LANUZZA, B</au><au>BUEMI, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Normotensive Offspring with Non-Dipper Hypertensive Parents Have Abnormal Sleep Pattern</atitle><jtitle>Blood pressure</jtitle><addtitle>Blood Press</addtitle><date>1998-05</date><risdate>1998</risdate><volume>7</volume><issue>2</issue><spage>76</spage><epage>80</epage><pages>76-80</pages><issn>0803-7051</issn><eissn>1651-1999</eissn><abstract>The objective of this study was to determine whether abnormal microstructure of sleep in non-dipper hypertensive patients was present in their offspring. Subjects included 11 normotensive offspring of non-dipper hypertensive parents (FH + ND), 6 of dipper hypertensive parents (FH + D) and 5 of normotensive parents (Controls). We measured blood pressure beat-to-beat by Finapres and all stages of sleep by polysomnographically recording simultaneously during spontaneous nocturnal sleep. We analysed blood pressure pattern for 4-min long random periods while the subjects were awake and during all stages of sleep; sleep efficiency (SE), sleep latency (SL), delta-sleep latency (delta-SL), REM sleep latency (REM-SL), Stage 1, Stage 2, Stage 3, Stage 4 and REM duration and percentage values, and microstructural aspects of sleep (arousal and microarousal temporization and features). FH + D and controls showed a fall in blood pressure greater than 10% in all stages of NREM sleep and in the FH + ND blood pressure fall in less than 10% of waking values in all NREM stages. REM sleep and heart rate were similar in the three groups during all stages of sleep. FH + ND showed the same number of arousals but more microarousals than FH + D and controls (p < 0.0001). Microarousals induced several stage shifts through lighter sleep. For this reason, FH + ND spent more time in stage 2 than FH + D and controls. In conclusion, offspring of non-dipper hypertension parents showed a greater number of microarousals than the other two groups.</abstract><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>9657533</pmid><doi>10.1080/080370598437439</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - physiology Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Humans Hypertension - genetics Hypertension - physiopathology Male Medical sciences Sleep - physiology |
title | Normotensive Offspring with Non-Dipper Hypertensive Parents Have Abnormal Sleep Pattern |
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