Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells

Human MutT homologue ( hMTH1) mRNA was overexpressed in SV-40-transformed non-tumorigenic human bronchial epithelial cells (BEAS-2B cells) and in 11 out of 12 human lung cancer cell lines relative to normal human bronchial epithelial cells. Expression levels of hMTH1 mRNA were inversely proportional...

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Veröffentlicht in:	FEBS letters 1998-06, Vol.429 (1), p.17-20
Hauptverfasser:	Kennedy, Christopher H, Cueto, Rafael, Belinsky, Steven A, Lechner, John F, Pryor, William A
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Oxo-deoxyguanosine Adaptor Proteins, Signal Transducing Biomarkers, Tumor - metabolism Fungal Proteins - genetics Fungal Proteins - metabolism Gene expression Human MutT homologue Humans Lung cancer Lung Neoplasms - metabolism Membrane Proteins Molecular marker Neoplasm Proteins - metabolism Oxidative Stress RNA, Messenger - metabolism Saccharomyces cerevisiae Proteins Tumor Cells, Cultured
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