31P NMR spectroscopy detects metabolic abnormalities in asymptomatic patients with hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) often causes sudden, unexpected death in adolescents and young adults. Alterations in myocardial metabolism are considered to be causes for contractile dysfunction. We examined the question of whether metabolic abnormalities antedate the manifestation of symptoms in...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1998-06, Vol.97 (25), p.2536-2542 |
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| creator | JUNG, W.-I SIEVERDING, L DIETZE, G. J BREUER, J HOESS, T WIDMAIER, S SCHMIDT, O BUNSE, M VAN ERCKELENS, F APITZ, J LUTZ, O |
| description | Hypertrophic cardiomyopathy (HCM) often causes sudden, unexpected death in adolescents and young adults. Alterations in myocardial metabolism are considered to be causes for contractile dysfunction. We examined the question of whether metabolic abnormalities antedate the manifestation of symptoms in patients with HCM.
Proton-decoupled 31P NMR spectroscopy of the anterior left ventricular wall of the heart of 14 young, asymptomatic patients with HCM was performed with a 1.5-T whole-body imager. Spectra of the phosphate metabolites were compared with those of normal control subjects. The patients exhibited a significantly reduced (P |
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Proton-decoupled 31P NMR spectroscopy of the anterior left ventricular wall of the heart of 14 young, asymptomatic patients with HCM was performed with a 1.5-T whole-body imager. Spectra of the phosphate metabolites were compared with those of normal control subjects. The patients exhibited a significantly reduced (P<0.02) ratio of phosphocreatine (PCr) to ATP of 1.98+/-0.37 (mean+/-SD), compared with 2.46+/-0.53 obtained in 11 normal control subjects. In addition, the group of patients with severe hypertrophy of the interventricular septum (n=8) showed a significantly increased (P<0.05) Pi-to-PCr ratio, with a Pi x 100/PCr of 20.0+/-8.3 versus 9.7+/-7.2 in control subjects. Both abnormalities are similar to those found in ischemic myocardium. This view is also supported by a significantly increased (P<0.01) phosphomonoester (PME)-to-PCr ratio, with a PME x 100/PCr of 20.7+/-11.2 compared with 8.4+/-6.7 in control subjects, indicating altered glucose metabolism.
31P NMR spectroscopy detects alterations of myocardial metabolism in asymptomatic patients with HCM. These alterations may contribute to the understanding of the pathophysiology and natural history of the disease.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>PMID: 9657474</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiomyopathy, Hypertrophic - metabolism ; Case-Control Studies ; Child ; Endocardial and cardiac valvular diseases ; Female ; Heart ; Humans ; Magnetic Resonance Spectroscopy - methods ; Male ; Medical sciences ; Myocardial Ischemia - metabolism ; Myocardium - metabolism ; Phosphorus Isotopes</subject><ispartof>Circulation (New York, N.Y.), 1998-06, Vol.97 (25), p.2536-2542</ispartof><rights>1998 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Jun 30, 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2314279$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9657474$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JUNG, W.-I</creatorcontrib><creatorcontrib>SIEVERDING, L</creatorcontrib><creatorcontrib>DIETZE, G. J</creatorcontrib><creatorcontrib>BREUER, J</creatorcontrib><creatorcontrib>HOESS, T</creatorcontrib><creatorcontrib>WIDMAIER, S</creatorcontrib><creatorcontrib>SCHMIDT, O</creatorcontrib><creatorcontrib>BUNSE, M</creatorcontrib><creatorcontrib>VAN ERCKELENS, F</creatorcontrib><creatorcontrib>APITZ, J</creatorcontrib><creatorcontrib>LUTZ, O</creatorcontrib><title>31P NMR spectroscopy detects metabolic abnormalities in asymptomatic patients with hypertrophic cardiomyopathy</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Hypertrophic cardiomyopathy (HCM) often causes sudden, unexpected death in adolescents and young adults. Alterations in myocardial metabolism are considered to be causes for contractile dysfunction. We examined the question of whether metabolic abnormalities antedate the manifestation of symptoms in patients with HCM.
Proton-decoupled 31P NMR spectroscopy of the anterior left ventricular wall of the heart of 14 young, asymptomatic patients with HCM was performed with a 1.5-T whole-body imager. Spectra of the phosphate metabolites were compared with those of normal control subjects. The patients exhibited a significantly reduced (P<0.02) ratio of phosphocreatine (PCr) to ATP of 1.98+/-0.37 (mean+/-SD), compared with 2.46+/-0.53 obtained in 11 normal control subjects. In addition, the group of patients with severe hypertrophy of the interventricular septum (n=8) showed a significantly increased (P<0.05) Pi-to-PCr ratio, with a Pi x 100/PCr of 20.0+/-8.3 versus 9.7+/-7.2 in control subjects. Both abnormalities are similar to those found in ischemic myocardium. This view is also supported by a significantly increased (P<0.01) phosphomonoester (PME)-to-PCr ratio, with a PME x 100/PCr of 20.7+/-11.2 compared with 8.4+/-6.7 in control subjects, indicating altered glucose metabolism.
31P NMR spectroscopy detects alterations of myocardial metabolism in asymptomatic patients with HCM. These alterations may contribute to the understanding of the pathophysiology and natural history of the disease.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cardiomyopathy, Hypertrophic - metabolism</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Endocardial and cardiac valvular diseases</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myocardial Ischemia - metabolism</subject><subject>Myocardium - metabolism</subject><subject>Phosphorus Isotopes</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLxDAUhYMo4zj6E4Qg4q7QvJulDL5gfCC6Lkma0gxNU5MW6b834ODCzb0czncPh3sE1ohhWlBG5DFYl2UpC0EwPgVnKe2z5ESwFVhJzgQVdA0Ggt7gy_M7TKM1UwzJhHGBjZ2yStDbSenQOwOVHkL0qneTswm6Aaq0-HEKXk3ZHfO0Qz74dlMHu2W0MWeNXbaMio0LfgmZ6ZZzcNKqPtmLw96Az_u7j-1jsXt9eNre7ooOMUQLWRmqsNa0ZZXUUjHdKN5og5umNZXllUHUlJJSRrEQCjPSlhYLWSHJW9NqsgE3v7ljDF-zTVPtXTK279Vgw5xqIWXFueQZvPoH7sMch9ytxghzRjgVGbo8QLP2tqnH6LyKS334YvavD75KRvVtVINx6Q_DBOWakvwAVil98Q</recordid><startdate>19980630</startdate><enddate>19980630</enddate><creator>JUNG, W.-I</creator><creator>SIEVERDING, L</creator><creator>DIETZE, G. J</creator><creator>BREUER, J</creator><creator>HOESS, T</creator><creator>WIDMAIER, S</creator><creator>SCHMIDT, O</creator><creator>BUNSE, M</creator><creator>VAN ERCKELENS, F</creator><creator>APITZ, J</creator><creator>LUTZ, O</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>19980630</creationdate><title>31P NMR spectroscopy detects metabolic abnormalities in asymptomatic patients with hypertrophic cardiomyopathy</title><author>JUNG, W.-I ; SIEVERDING, L ; DIETZE, G. J ; BREUER, J ; HOESS, T ; WIDMAIER, S ; SCHMIDT, O ; BUNSE, M ; VAN ERCKELENS, F ; APITZ, J ; LUTZ, O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h1514-98c4a2bb4f589b9a5bda6dbc2ddfc8e68c14c094454277a253f0e2798196fcfb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cardiomyopathy, Hypertrophic - metabolism</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Endocardial and cardiac valvular diseases</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Myocardial Ischemia - metabolism</topic><topic>Myocardium - metabolism</topic><topic>Phosphorus Isotopes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JUNG, W.-I</creatorcontrib><creatorcontrib>SIEVERDING, L</creatorcontrib><creatorcontrib>DIETZE, G. J</creatorcontrib><creatorcontrib>BREUER, J</creatorcontrib><creatorcontrib>HOESS, T</creatorcontrib><creatorcontrib>WIDMAIER, S</creatorcontrib><creatorcontrib>SCHMIDT, O</creatorcontrib><creatorcontrib>BUNSE, M</creatorcontrib><creatorcontrib>VAN ERCKELENS, F</creatorcontrib><creatorcontrib>APITZ, J</creatorcontrib><creatorcontrib>LUTZ, O</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JUNG, W.-I</au><au>SIEVERDING, L</au><au>DIETZE, G. J</au><au>BREUER, J</au><au>HOESS, T</au><au>WIDMAIER, S</au><au>SCHMIDT, O</au><au>BUNSE, M</au><au>VAN ERCKELENS, F</au><au>APITZ, J</au><au>LUTZ, O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>31P NMR spectroscopy detects metabolic abnormalities in asymptomatic patients with hypertrophic cardiomyopathy</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>1998-06-30</date><risdate>1998</risdate><volume>97</volume><issue>25</issue><spage>2536</spage><epage>2542</epage><pages>2536-2542</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Hypertrophic cardiomyopathy (HCM) often causes sudden, unexpected death in adolescents and young adults. Alterations in myocardial metabolism are considered to be causes for contractile dysfunction. We examined the question of whether metabolic abnormalities antedate the manifestation of symptoms in patients with HCM.
Proton-decoupled 31P NMR spectroscopy of the anterior left ventricular wall of the heart of 14 young, asymptomatic patients with HCM was performed with a 1.5-T whole-body imager. Spectra of the phosphate metabolites were compared with those of normal control subjects. The patients exhibited a significantly reduced (P<0.02) ratio of phosphocreatine (PCr) to ATP of 1.98+/-0.37 (mean+/-SD), compared with 2.46+/-0.53 obtained in 11 normal control subjects. In addition, the group of patients with severe hypertrophy of the interventricular septum (n=8) showed a significantly increased (P<0.05) Pi-to-PCr ratio, with a Pi x 100/PCr of 20.0+/-8.3 versus 9.7+/-7.2 in control subjects. Both abnormalities are similar to those found in ischemic myocardium. This view is also supported by a significantly increased (P<0.01) phosphomonoester (PME)-to-PCr ratio, with a PME x 100/PCr of 20.7+/-11.2 compared with 8.4+/-6.7 in control subjects, indicating altered glucose metabolism.
31P NMR spectroscopy detects alterations of myocardial metabolism in asymptomatic patients with HCM. These alterations may contribute to the understanding of the pathophysiology and natural history of the disease.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>9657474</pmid><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Biological and medical sciences Cardiology. Vascular system Cardiomyopathy, Hypertrophic - metabolism Case-Control Studies Child Endocardial and cardiac valvular diseases Female Heart Humans Magnetic Resonance Spectroscopy - methods Male Medical sciences Myocardial Ischemia - metabolism Myocardium - metabolism Phosphorus Isotopes |
| title | 31P NMR spectroscopy detects metabolic abnormalities in asymptomatic patients with hypertrophic cardiomyopathy |
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