Prediction of the DST results in depressives by means of urinary-free cortisol excretion, dexamethasone levels, and age
This study investigates the relationships between cortisol escape from suppression by dexamethasone during a depressive episode, and the baseline activity of the hypothalamic-pituitary-adrenal (HPA) axis, circulating dexamethasone levels, and age. To this end, we measured urinary-free cortisol (UFC)...
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| Veröffentlicht in: | Biological psychiatry (1969) 1990-08, Vol.28 (4), p.349-357 |
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| container_title | Biological psychiatry (1969) |
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| creator | Maes, M. Jacobs, M.-P. Suy, E. Minner, B. Raus, J. |
| description | This study investigates the relationships between cortisol escape from suppression by dexamethasone during a depressive episode, and the baseline activity of the hypothalamic-pituitary-adrenal (HPA) axis, circulating dexamethasone levels, and age. To this end, we measured urinary-free cortisol (UFC) excretion in 24-hr urine samples and the 8
am cortisol and dexamethasone levels after administration of 1 mg dexamethasone in 50 depressive patients. We found that up to 54% of the variance in the postdexamethasone cortisol values could be explained by the multiple regression on UFC, age, and dexamethasone levels. By utilizing these three parameters, the dexamethasone suppression test (DST) nonsuppressor/suppressor state was correctly identified in 92% of the subjects. It was shown that an important part of the variance in postdexamethasone cortisol is actually background variance, irrelevant to depression and produced by the cumulative effects of the three aforementioned parameters. Only a small part ( |
| doi_str_mv | 10.1016/0006-3223(90)90662-L |
| format | Article |
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am cortisol and dexamethasone levels after administration of 1 mg dexamethasone in 50 depressive patients. We found that up to 54% of the variance in the postdexamethasone cortisol values could be explained by the multiple regression on UFC, age, and dexamethasone levels. By utilizing these three parameters, the dexamethasone suppression test (DST) nonsuppressor/suppressor state was correctly identified in 92% of the subjects. It was shown that an important part of the variance in postdexamethasone cortisol is actually background variance, irrelevant to depression and produced by the cumulative effects of the three aforementioned parameters. Only a small part (<20%) of the variance in postdexamethasone cortisol is determined by the actual depressive state. It was concluded that (1) baseline hypersecretion of cortisol, (2) decrements in the bicavailability of the test substance, (3) increasing age, and (4) the depressive state per se—all of which are cumulative—contribute independently to cortisol escape from suppression by 1 mg dexamethasone.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/0006-3223(90)90662-L</identifier><identifier>PMID: 2397250</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Age Factors ; Aged ; Biological and medical sciences ; Depression ; Depressive Disorder - diagnosis ; Depressive Disorder - psychology ; Depressive Disorder - urine ; Dexamethasone - pharmacokinetics ; Female ; Humans ; Hydrocortisone - urine ; Male ; Medical sciences ; Middle Aged ; Mood disorders ; Personality Tests ; Prospective Studies ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry</subject><ispartof>Biological psychiatry (1969), 1990-08, Vol.28 (4), p.349-357</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-d84448a471e95a4418ff3cbe795d848ad992d82c50bae2f5124c47b29742fdba3</citedby><cites>FETCH-LOGICAL-c387t-d84448a471e95a4418ff3cbe795d848ad992d82c50bae2f5124c47b29742fdba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/000632239090662L$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19644363$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2397250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maes, M.</creatorcontrib><creatorcontrib>Jacobs, M.-P.</creatorcontrib><creatorcontrib>Suy, E.</creatorcontrib><creatorcontrib>Minner, B.</creatorcontrib><creatorcontrib>Raus, J.</creatorcontrib><title>Prediction of the DST results in depressives by means of urinary-free cortisol excretion, dexamethasone levels, and age</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>This study investigates the relationships between cortisol escape from suppression by dexamethasone during a depressive episode, and the baseline activity of the hypothalamic-pituitary-adrenal (HPA) axis, circulating dexamethasone levels, and age. To this end, we measured urinary-free cortisol (UFC) excretion in 24-hr urine samples and the 8
am cortisol and dexamethasone levels after administration of 1 mg dexamethasone in 50 depressive patients. We found that up to 54% of the variance in the postdexamethasone cortisol values could be explained by the multiple regression on UFC, age, and dexamethasone levels. By utilizing these three parameters, the dexamethasone suppression test (DST) nonsuppressor/suppressor state was correctly identified in 92% of the subjects. It was shown that an important part of the variance in postdexamethasone cortisol is actually background variance, irrelevant to depression and produced by the cumulative effects of the three aforementioned parameters. Only a small part (<20%) of the variance in postdexamethasone cortisol is determined by the actual depressive state. It was concluded that (1) baseline hypersecretion of cortisol, (2) decrements in the bicavailability of the test substance, (3) increasing age, and (4) the depressive state per se—all of which are cumulative—contribute independently to cortisol escape from suppression by 1 mg dexamethasone.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Depression</subject><subject>Depressive Disorder - diagnosis</subject><subject>Depressive Disorder - psychology</subject><subject>Depressive Disorder - urine</subject><subject>Dexamethasone - pharmacokinetics</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocortisone - urine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Personality Tests</subject><subject>Prospective Studies</subject><subject>Psychology. 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Psychiatry</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV1rFDEUhoModVv9Bwq5USp0NMlkJpMbQeonLChYr0MmOWMjM8k2Z2Zt_70Zd6l3XoXDed6X5Akhzzh7zRlv3zDG2qoWoj7X7JVmbSuq7QOy4Z2qKyGZeEg298hjcor4q4xKCH5CTkStlWjYhvz-lsEHN4cUaRrofA30_fcrmgGXcUYaIvWwKxOGPSDt7-gENuKKLjlEm--qIQNQl_IcMI0Ubl2Gte2iBG_tBPO1xRSBjrCHES-ojZ7an_CEPBrsiPD0eJ6RHx8_XF1-rrZfP325fLetXN2pufKdlLKzUnHQjZWSd8NQux6Ubsqqs15r4TvhGtZbEEPDhXRS9UIrKQbf2_qMvDz07nK6WQBnMwV0MI42QlrQKK27Rqu2gPIAupwQMwxml8NUHmg4M6tvs8o0q0yjmfnr22xL7Pmxf-kn8Peho-Cyf3HcW3R2HLKNLuC_bt1KWbd14d4euCIJ9gGyQRcguvI5GdxsfAr_v8gfVBidWQ</recordid><startdate>19900815</startdate><enddate>19900815</enddate><creator>Maes, M.</creator><creator>Jacobs, M.-P.</creator><creator>Suy, E.</creator><creator>Minner, B.</creator><creator>Raus, J.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900815</creationdate><title>Prediction of the DST results in depressives by means of urinary-free cortisol excretion, dexamethasone levels, and age</title><author>Maes, M. ; Jacobs, M.-P. ; Suy, E. ; Minner, B. ; Raus, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-d84448a471e95a4418ff3cbe795d848ad992d82c50bae2f5124c47b29742fdba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Depression</topic><topic>Depressive Disorder - diagnosis</topic><topic>Depressive Disorder - psychology</topic><topic>Depressive Disorder - urine</topic><topic>Dexamethasone - pharmacokinetics</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocortisone - urine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Personality Tests</topic><topic>Prospective Studies</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maes, M.</creatorcontrib><creatorcontrib>Jacobs, M.-P.</creatorcontrib><creatorcontrib>Suy, E.</creatorcontrib><creatorcontrib>Minner, B.</creatorcontrib><creatorcontrib>Raus, J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maes, M.</au><au>Jacobs, M.-P.</au><au>Suy, E.</au><au>Minner, B.</au><au>Raus, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediction of the DST results in depressives by means of urinary-free cortisol excretion, dexamethasone levels, and age</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>1990-08-15</date><risdate>1990</risdate><volume>28</volume><issue>4</issue><spage>349</spage><epage>357</epage><pages>349-357</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>This study investigates the relationships between cortisol escape from suppression by dexamethasone during a depressive episode, and the baseline activity of the hypothalamic-pituitary-adrenal (HPA) axis, circulating dexamethasone levels, and age. To this end, we measured urinary-free cortisol (UFC) excretion in 24-hr urine samples and the 8
am cortisol and dexamethasone levels after administration of 1 mg dexamethasone in 50 depressive patients. We found that up to 54% of the variance in the postdexamethasone cortisol values could be explained by the multiple regression on UFC, age, and dexamethasone levels. By utilizing these three parameters, the dexamethasone suppression test (DST) nonsuppressor/suppressor state was correctly identified in 92% of the subjects. It was shown that an important part of the variance in postdexamethasone cortisol is actually background variance, irrelevant to depression and produced by the cumulative effects of the three aforementioned parameters. Only a small part (<20%) of the variance in postdexamethasone cortisol is determined by the actual depressive state. It was concluded that (1) baseline hypersecretion of cortisol, (2) decrements in the bicavailability of the test substance, (3) increasing age, and (4) the depressive state per se—all of which are cumulative—contribute independently to cortisol escape from suppression by 1 mg dexamethasone.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2397250</pmid><doi>10.1016/0006-3223(90)90662-L</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Age Factors Aged Biological and medical sciences Depression Depressive Disorder - diagnosis Depressive Disorder - psychology Depressive Disorder - urine Dexamethasone - pharmacokinetics Female Humans Hydrocortisone - urine Male Medical sciences Middle Aged Mood disorders Personality Tests Prospective Studies Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry |
| title | Prediction of the DST results in depressives by means of urinary-free cortisol excretion, dexamethasone levels, and age |
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