Is decreased imipramine binding by platelet membranes in major depression associated with plasma autoantibodies to imipramine binding sites?

Decreases in super(3)H-imipramine binding sites on platelets (B sub(max)) without a significant change in the ligand affinity (K sub(d)) are found in some patients with major depression. The mechanism underlying the reduction in binding site density is not understood. IgGautoantibodies binding to a...

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Veröffentlicht in:	Biological psychiatry (1969) 1990-08, Vol.28 (4), p.365-368
Hauptverfasser:	Alosachie, Iyad, Peter, James B., Tsuchihashi, Hiroshi, Knight, David L., Nemeroff, Charles B.
Format:	Artikel
Sprache:	eng
Schlagworte:	autoantibodies Autoantibodies - analysis Blood Platelets - immunology Carrier Proteins depression Depressive Disorder - immunology Humans imipramine Imipramine - pharmacokinetics Immunoglobulin G - analysis mental disorders plasma membranes Radioligand Assay Receptors, Drug Receptors, Neurotransmitter - immunology
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