Is decreased imipramine binding by platelet membranes in major depression associated with plasma autoantibodies to imipramine binding sites?
Decreases in super(3)H-imipramine binding sites on platelets (B sub(max)) without a significant change in the ligand affinity (K sub(d)) are found in some patients with major depression. The mechanism underlying the reduction in binding site density is not understood. IgGautoantibodies binding to a...
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| Veröffentlicht in: | Biological psychiatry (1969) 1990-08, Vol.28 (4), p.365-368 |
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| container_end_page | 368 |
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| container_issue | 4 |
| container_start_page | 365 |
| container_title | Biological psychiatry (1969) |
| container_volume | 28 |
| creator | Alosachie, Iyad Peter, James B. Tsuchihashi, Hiroshi Knight, David L. Nemeroff, Charles B. |
| description | Decreases in super(3)H-imipramine binding sites on platelets (B sub(max)) without a significant change in the ligand affinity (K sub(d)) are found in some patients with major depression. The mechanism underlying the reduction in binding site density is not understood. IgGautoantibodies binding to a variety of specific receptors are known to be important in the pathogenesis of several diseases, including Addison's disease, Graves' disease, myasthenia gravis, and insulin-resistant diabetes mellitus. Accordingly, we studied the effects of IgG from untreated patients with major depression on super(3)H-imipramine binding on platelets from normal volunteers. |
| doi_str_mv | 10.1016/0006-3223(90)90665-O |
| format | Article |
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Accordingly, we studied the effects of IgG from untreated patients with major depression on super(3)H-imipramine binding on platelets from normal volunteers.</description><subject>autoantibodies</subject><subject>Autoantibodies - analysis</subject><subject>Blood Platelets - immunology</subject><subject>Carrier Proteins</subject><subject>depression</subject><subject>Depressive Disorder - immunology</subject><subject>Humans</subject><subject>imipramine</subject><subject>Imipramine - pharmacokinetics</subject><subject>Immunoglobulin G - analysis</subject><subject>mental disorders</subject><subject>plasma membranes</subject><subject>Radioligand Assay</subject><subject>Receptors, Drug</subject><subject>Receptors, Neurotransmitter - immunology</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQhy1EVbaFNwDJJwSHtI7tJPYFhCr-VKq0l3K2HHsMrpI4eLxFfQceGi-76gnBybbm983I8xHysmUXLWv7S8ZY3wjOxRvN3mrW912zfUI2rRpEwyXjT8nmMfKMnCHe1efAeXtKTnnbq6EXG_LrGqkHl8EieBrnuGY7xwXoGBcfl290fKDrZAtMUOgM85jtAkjjQmd7l3Jl1wyIMS3UIiYXa9TTn7F832M4W2p3JdmlxDH5WMmS_jYFYwF8_5ycBDshvDie5-Trp4-3V1-am-3n66sPN40TSpVGDlaDc5x5AKaC5BJ4qPcwcNX5EZToBQscYAhBB80ldx56JRyXOsjOi3Py-tB3zenHDrCYOaKDaap_Szs0g9aqG7T6b7DtlKyb7GpQHoIuJ8QMwaw5zjY_mJaZvS2zV2H2Koxm5o8ts63Yq2P_3TiDf4SOemr93aEOdRv3EbJBF2Fx4GMGV4xP8d8DfgMRwagb</recordid><startdate>19900815</startdate><enddate>19900815</enddate><creator>Alosachie, Iyad</creator><creator>Peter, James B.</creator><creator>Tsuchihashi, Hiroshi</creator><creator>Knight, David L.</creator><creator>Nemeroff, Charles B.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19900815</creationdate><title>Is decreased imipramine binding by platelet membranes in major depression associated with plasma autoantibodies to imipramine binding sites?</title><author>Alosachie, Iyad ; 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| fulltext | fulltext |
| identifier | ISSN: 0006-3223 |
| ispartof | Biological psychiatry (1969), 1990-08, Vol.28 (4), p.365-368 |
| issn | 0006-3223 1873-2402 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79985798 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | autoantibodies Autoantibodies - analysis Blood Platelets - immunology Carrier Proteins depression Depressive Disorder - immunology Humans imipramine Imipramine - pharmacokinetics Immunoglobulin G - analysis mental disorders plasma membranes Radioligand Assay Receptors, Drug Receptors, Neurotransmitter - immunology |
| title | Is decreased imipramine binding by platelet membranes in major depression associated with plasma autoantibodies to imipramine binding sites? |
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