Alternative promoter usage and tissue specific expression of the mouse somatostatin receptor 2 gene
We have cloned the 5′ upstream regulatory region of the mouse somatostatin receptor 2 gene. Its genomic organization is novel among all somatostatin receptor genes. It contains two previously unrecognized exons, separated by introns larger than 25 kb, and three tissue and cell specific alternative p...
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| Veröffentlicht in: | FEBS letters 1998-05, Vol.428 (3), p.165-170 |
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| creator | Kraus, Jürgen Wöltje, Michael Schönwetter, Nadja Höllt, Volker |
| description | We have cloned the 5′ upstream regulatory region of the mouse somatostatin receptor 2 gene. Its genomic organization is novel among all somatostatin receptor genes. It contains two previously unrecognized exons, separated by introns larger than 25 kb, and three tissue and cell specific alternative promoters. The first promoter in front of exon 1 is active only in AtT-20 tumor cells. The second promoter, located 5′ to exon 2, is used in brain, pituitary, adrenals, pancreas, NG 108-15 and AtT-20 cells. Furthermore, it contains putative DNA elements for regulation by glucocorticoids, estradiol and cAMP. A third promoter, located in exon 3, is additionally used in lung, kidney and spleen. |
| doi_str_mv | 10.1016/S0014-5793(98)00520-1 |
| format | Article |
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Its genomic organization is novel among all somatostatin receptor genes. It contains two previously unrecognized exons, separated by introns larger than 25 kb, and three tissue and cell specific alternative promoters. The first promoter in front of exon 1 is active only in AtT-20 tumor cells. The second promoter, located 5′ to exon 2, is used in brain, pituitary, adrenals, pancreas, NG 108-15 and AtT-20 cells. Furthermore, it contains putative DNA elements for regulation by glucocorticoids, estradiol and cAMP. A third promoter, located in exon 3, is additionally used in lung, kidney and spleen.</description><subject>Alternative promoter usage</subject><subject>Alternative Splicing</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Cloning, Molecular</subject><subject>DNA Primers</subject><subject>Exons</subject><subject>Gene Expression Regulation</subject><subject>Introns</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Organ Specificity</subject><subject>Polymerase Chain Reaction</subject><subject>Promoter Regions, Genetic</subject><subject>Receptors, Somatostatin - biosynthesis</subject><subject>Receptors, Somatostatin - genetics</subject><subject>Recombinant Proteins - biosynthesis</subject><subject>Somatostatin receptor 2</subject><subject>Tissue specific gene expression</subject><subject>Transcription, Genetic</subject><subject>Tumor Cells, Cultured</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1vFiEUhYnR1LcfP6EJK2MXozADA6xMbVpr0sSFuiYMXCpmZhiBqe2_L-9HutUVuZxzz733Qeickg-U0P7jd0Ioa7hQ3XslLwjhLWnoK7ShUnRNx3r5Gm1eLG_Rcc6_Sa0lVUfoSPWc0VZukL0cC6TZlPAAeElxirXEazb3gM3scAk5r4DzAjb4YDE8LglyDnHG0ePyC_AU11wNcTIl5lKDZpzAwlJiwi2-hxlO0Rtvxgxnh_cE_by5_nF129x9-_L16vKusbyTtBFCUUOY9aB6IXvnBwfEO2cMSNt6xjgjwyAG4ztnpFPAHe8Fo710Q0sU607Qu31uvePPCrnoKWQL42hmqEtqoZTkPRXVyPdGm2LOCbxeUphMetKU6C1cvYOrt-S0knoHV9Pad34YsA4TuJeuA82q3-71v2GEp_8L1TfXn9udshWU3H1vR33aR0EF9hAg6WwDzBZcqHSLdjH8Y9lnrwWfbw</recordid><startdate>19980529</startdate><enddate>19980529</enddate><creator>Kraus, Jürgen</creator><creator>Wöltje, Michael</creator><creator>Schönwetter, Nadja</creator><creator>Höllt, Volker</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980529</creationdate><title>Alternative promoter usage and tissue specific expression of the mouse somatostatin receptor 2 gene</title><author>Kraus, Jürgen ; Wöltje, Michael ; Schönwetter, Nadja ; Höllt, Volker</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5381-7791a04cfe96786dfbde0fddaae8c2f44540bb7baf3da8d9e5d5674168db20943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Alternative promoter usage</topic><topic>Alternative Splicing</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Cloning, Molecular</topic><topic>DNA Primers</topic><topic>Exons</topic><topic>Gene Expression Regulation</topic><topic>Introns</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>Organ Specificity</topic><topic>Polymerase Chain Reaction</topic><topic>Promoter Regions, Genetic</topic><topic>Receptors, Somatostatin - biosynthesis</topic><topic>Receptors, Somatostatin - genetics</topic><topic>Recombinant Proteins - biosynthesis</topic><topic>Somatostatin receptor 2</topic><topic>Tissue specific gene expression</topic><topic>Transcription, Genetic</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kraus, Jürgen</creatorcontrib><creatorcontrib>Wöltje, Michael</creatorcontrib><creatorcontrib>Schönwetter, Nadja</creatorcontrib><creatorcontrib>Höllt, Volker</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kraus, Jürgen</au><au>Wöltje, Michael</au><au>Schönwetter, Nadja</au><au>Höllt, Volker</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alternative promoter usage and tissue specific expression of the mouse somatostatin receptor 2 gene</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1998-05-29</date><risdate>1998</risdate><volume>428</volume><issue>3</issue><spage>165</spage><epage>170</epage><pages>165-170</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>We have cloned the 5′ upstream regulatory region of the mouse somatostatin receptor 2 gene. Its genomic organization is novel among all somatostatin receptor genes. It contains two previously unrecognized exons, separated by introns larger than 25 kb, and three tissue and cell specific alternative promoters. The first promoter in front of exon 1 is active only in AtT-20 tumor cells. The second promoter, located 5′ to exon 2, is used in brain, pituitary, adrenals, pancreas, NG 108-15 and AtT-20 cells. Furthermore, it contains putative DNA elements for regulation by glucocorticoids, estradiol and cAMP. A third promoter, located in exon 3, is additionally used in lung, kidney and spleen.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>9654128</pmid><doi>10.1016/S0014-5793(98)00520-1</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | FEBS letters, 1998-05, Vol.428 (3), p.165-170 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; ScienceDirect Journals (5 years ago - present); Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Alternative promoter usage Alternative Splicing Amino Acid Sequence Animals Base Sequence Cloning, Molecular DNA Primers Exons Gene Expression Regulation Introns Mice Molecular Sequence Data Organ Specificity Polymerase Chain Reaction Promoter Regions, Genetic Receptors, Somatostatin - biosynthesis Receptors, Somatostatin - genetics Recombinant Proteins - biosynthesis Somatostatin receptor 2 Tissue specific gene expression Transcription, Genetic Tumor Cells, Cultured |
| title | Alternative promoter usage and tissue specific expression of the mouse somatostatin receptor 2 gene |
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