Isochromosome (8q) in four patients with adenocarcinoma of the lung
We report an isochromosome, i(8q), in combination with many other cytogenetic changes in tumor cells from four patients with lung cancer. In each case, the tumor subtype was adenocarcinoma. This isochromosome has not been identified in primary tumors from patients with other histological types of lu...
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| Veröffentlicht in: | Cancer genetics and cytogenetics 1990-09, Vol.48 (2), p.203-207 |
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| container_title | Cancer genetics and cytogenetics |
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| creator | Miura, Ikuo Resau, James Tomiyasu, Takafumi Testa, Joseph R. |
| description | We report an isochromosome, i(8q), in combination with many other cytogenetic changes in tumor cells from four patients with lung cancer. In each case, the tumor subtype was adenocarcinoma. This isochromosome has not been identified in primary tumors from patients with other histological types of lung cancer. Among the few previously reported cytogenetic analyses of pulmonary adenocarcinomas, i(8q) has been observed in four additional patients. Therefore, i(8q) represents a recurring change in this specific type of lung cancer. In addition to i(8q), tumor cells from each of our four patients had different abnormalities of 17p, and two patients had alterations of 3p as well. |
| doi_str_mv | 10.1016/0165-4608(90)90121-P |
| format | Article |
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In each case, the tumor subtype was adenocarcinoma. This isochromosome has not been identified in primary tumors from patients with other histological types of lung cancer. Among the few previously reported cytogenetic analyses of pulmonary adenocarcinomas, i(8q) has been observed in four additional patients. Therefore, i(8q) represents a recurring change in this specific type of lung cancer. In addition to i(8q), tumor cells from each of our four patients had different abnormalities of 17p, and two patients had alterations of 3p as well.</description><subject>adenocarcinoma</subject><subject>Adenocarcinoma - genetics</subject><subject>Biological and medical sciences</subject><subject>chromosome 8</subject><subject>Chromosome Aberrations</subject><subject>Chromosomes, Human, Pair 17</subject><subject>Chromosomes, Human, Pair 3</subject><subject>Chromosomes, Human, Pair 8</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EareFf9BKvoDaQ8COvy9IaNVCpUr0AGfLGdtdoyTe2klR_z1ZdlVu5TCawzzvq9GD0BklHymh8tMyouGS6AtDLg2hLW3uXqEV1Yo1nAv5Gq2ekWN0UusvQohqjTxCRy0ziot2hdY3NcOm5CHXPAR8oR8ucRpxzHPBWzelME4V_07TBjsfxgyuQBrz4HCOeNoE3M_j_Vv0Jrq-hneHfYp-Xl_9WH9rbr9_vVl_uW2AMTY1YDzIthNtlKC4N7yTQKiX4HXniQKioo8KhNGtVjxEpjUlXIiOgSIOAjtFH_a925If5lAnO6QKoe_dGPJcrTJGs1aJ_4JUKKGJUQvI9yCUXGsJ0W5LGlx5spTYnWS7M2h3Bq0h9q9ke7fEzg_9czcE_xw6WF3u7w93V8H1sbgRUv3XvbypjZYL93nPhcXaYwrFVliMQ_CpBJisz-nlR_4ALziXqA</recordid><startdate>199009</startdate><enddate>199009</enddate><creator>Miura, Ikuo</creator><creator>Resau, James</creator><creator>Tomiyasu, Takafumi</creator><creator>Testa, Joseph R.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T3</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>199009</creationdate><title>Isochromosome (8q) in four patients with adenocarcinoma of the lung</title><author>Miura, Ikuo ; Resau, James ; Tomiyasu, Takafumi ; Testa, Joseph R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c333t-c9dc62b52f6c74d94b6c01d6cd8bd07c07fdf7c5982874ef38810455b3c70ace3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>adenocarcinoma</topic><topic>Adenocarcinoma - genetics</topic><topic>Biological and medical sciences</topic><topic>chromosome 8</topic><topic>Chromosome Aberrations</topic><topic>Chromosomes, Human, Pair 17</topic><topic>Chromosomes, Human, Pair 3</topic><topic>Chromosomes, Human, Pair 8</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>online_resources</toplevel><creatorcontrib>Miura, Ikuo</creatorcontrib><creatorcontrib>Resau, James</creatorcontrib><creatorcontrib>Tomiyasu, Takafumi</creatorcontrib><creatorcontrib>Testa, Joseph R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Human Genome Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miura, Ikuo</au><au>Resau, James</au><au>Tomiyasu, Takafumi</au><au>Testa, Joseph R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isochromosome (8q) in four patients with adenocarcinoma of the lung</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>1990-09</date><risdate>1990</risdate><volume>48</volume><issue>2</issue><spage>203</spage><epage>207</epage><pages>203-207</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><coden>CGCYDF</coden><abstract>We report an isochromosome, i(8q), in combination with many other cytogenetic changes in tumor cells from four patients with lung cancer. In each case, the tumor subtype was adenocarcinoma. This isochromosome has not been identified in primary tumors from patients with other histological types of lung cancer. Among the few previously reported cytogenetic analyses of pulmonary adenocarcinomas, i(8q) has been observed in four additional patients. Therefore, i(8q) represents a recurring change in this specific type of lung cancer. In addition to i(8q), tumor cells from each of our four patients had different abnormalities of 17p, and two patients had alterations of 3p as well.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2397452</pmid><doi>10.1016/0165-4608(90)90121-P</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | adenocarcinoma Adenocarcinoma - genetics Biological and medical sciences chromosome 8 Chromosome Aberrations Chromosomes, Human, Pair 17 Chromosomes, Human, Pair 3 Chromosomes, Human, Pair 8 Female Humans Lung Neoplasms - genetics Male Medical sciences Middle Aged Pneumology Tumors of the respiratory system and mediastinum |
| title | Isochromosome (8q) in four patients with adenocarcinoma of the lung |
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