Cell turnover parameters in small and large cell varieties of primary intestinal non‐hodgkin's lymphoma
BACKGROUND In contrast to primary gastric lymphoma, primary intestinal lymphoma is an uncommon condition with a poorer outcome, perhaps due to differences in its pathogenesis. In this study, the authors analyzed the roles of proliferation and apoptosis in the pathogenesis of intestinal lymphoma. MET...
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| Veröffentlicht in: | Cancer 1998-07, Vol.83 (1), p.158-165 |
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| creator | Gisbertz, Ingrid A. M. Schouten, Harry C. Bot, Fredrik J Arends, Jan‐Willem |
| description | BACKGROUND
In contrast to primary gastric lymphoma, primary intestinal lymphoma is an uncommon condition with a poorer outcome, perhaps due to differences in its pathogenesis. In this study, the authors analyzed the roles of proliferation and apoptosis in the pathogenesis of intestinal lymphoma.
METHODS
Fifty‐one cases of intestinal non‐Hodgkin's lymphoma (NHL) (10 small B‐cell mucosa‐associated lymphoid tissue [MALT] NHLs, 12 large B‐cell MALT NHLs, 18 large B‐cell NHLs, 2 small T‐cell NHLs, 7 large T‐cell NHLs, and 2 mantle cell NHLs) were studied for the immunohistochemical expression of MIB‐1 and the TUNEL assay as well as the expresssion of bcl‐2 and p53, both of which are regulatory gene products involved in apoptosis.
RESULTS
The median proliferation index (PI) was 37.3%, and the median apoptotic index (AI) was 1.10%. The respective values of PI and AI were 5.8% and 0.06% in small B‐cell MALT lymphoma, 52.8% and 0.24% in large B‐cell MALT lymphoma, 58.85% and 1.36% in large B‐cell lymphoma, 30.9% and 1.93% in mantle cell lymphoma, 18.13% and 1.25% in small T‐cell lymphoma, and 43.4% and 1.93% in large T‐cell lymphoma. In an analysis of B‐cell NHL only (with mantle cell NHL excluded), proliferative and apoptotic indices were positively correlated (correlation coefficient = 0.563, P < 0.001). Furthermore, high bcl‐2 expression was inversely correlated with both PI and AI. Expression of p53 was observed in 8 cases (1 small cell lymphoma and 7 large cell lymphomas).
CONCLUSIONS
Small cell lymphomas had low AI and PI values, whereas large cell lymphomas had high AI and PI values. Apoptosis and proliferation were positively correlated, and higher expression of bcl‐2 was associated with lower rates of apoptosis. Cancer 1998;83:158‐165. © 1998 American Cancer Society.
An analysis of the role of proliferation and apoptosis in primary intestinal non‐Hodgkin's lymphoma demonstrated that these cell turnover parameters are different in small and large cell varieties of the disease. |
| doi_str_mv | 10.1002/(SICI)1097-0142(19980701)83:1<158::AID-CNCR21>3.0.CO;2-V |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79982854</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79982854</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3991-6c72e91f3e43b0e15295e02be2e2ecba864cfa3fc71cdd80885c3adc76c5c0293</originalsourceid><addsrcrecordid>eNqFkc1uEzEUhS0EKiHwCEheIGgXE67tzIwdEKIa_iJVROKnqthcOR5P6zI_wZ4UZccj8Iw8CR5lyAYk5IVl3-Oj4_MR8pLBjAHwp8cfl8XyhIHKE2BzfsyUkpADO5FiwZ6zVC4Wp8tXSfG--MDZCzGDWbF6xpPzW2RyeHSbTABAJulcXNwl90K4jsecp-KIHKksTQVkE-IKW9e03_q2u7GebrTXje2tD9S1NDQ6DnVb0lr7S0vNoL3R3tne2UC7im68a7TfRXFvQ-9aXdO2a3_9-HnVlZdfXfsk0HrXbK66Rt8ndypdB_tg3Kfk85vXn4p3ydnq7bI4PUuMUIolmcm5VawSdi7WYFnKVWqBry2Py6y1zOam0qIyOTNlKUHK1AhdmjwzqQGuxJQ83vtufPdtG1Nh48KQXLe22wbMY5VcxlKm5GIvNL4LwdsKx98gAxwoIA4UcCgUh0LxDwWUAhlGCoiRAu4poEDAYoUcz6P1wzHDdt3Y8mA81h7nj8a5DkbXldetceEg4zzLQIko-7KXfXe13f0V77_p_hluvBG_Afm5s1k</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79982854</pqid></control><display><type>article</type><title>Cell turnover parameters in small and large cell varieties of primary intestinal non‐hodgkin's lymphoma</title><source>MEDLINE</source><source>Wiley Free Content</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library All Journals</source><source>Alma/SFX Local Collection</source><creator>Gisbertz, Ingrid A. M. ; Schouten, Harry C. ; Bot, Fredrik J ; Arends, Jan‐Willem</creator><creatorcontrib>Gisbertz, Ingrid A. M. ; Schouten, Harry C. ; Bot, Fredrik J ; Arends, Jan‐Willem</creatorcontrib><description>BACKGROUND
In contrast to primary gastric lymphoma, primary intestinal lymphoma is an uncommon condition with a poorer outcome, perhaps due to differences in its pathogenesis. In this study, the authors analyzed the roles of proliferation and apoptosis in the pathogenesis of intestinal lymphoma.
METHODS
Fifty‐one cases of intestinal non‐Hodgkin's lymphoma (NHL) (10 small B‐cell mucosa‐associated lymphoid tissue [MALT] NHLs, 12 large B‐cell MALT NHLs, 18 large B‐cell NHLs, 2 small T‐cell NHLs, 7 large T‐cell NHLs, and 2 mantle cell NHLs) were studied for the immunohistochemical expression of MIB‐1 and the TUNEL assay as well as the expresssion of bcl‐2 and p53, both of which are regulatory gene products involved in apoptosis.
RESULTS
The median proliferation index (PI) was 37.3%, and the median apoptotic index (AI) was 1.10%. The respective values of PI and AI were 5.8% and 0.06% in small B‐cell MALT lymphoma, 52.8% and 0.24% in large B‐cell MALT lymphoma, 58.85% and 1.36% in large B‐cell lymphoma, 30.9% and 1.93% in mantle cell lymphoma, 18.13% and 1.25% in small T‐cell lymphoma, and 43.4% and 1.93% in large T‐cell lymphoma. In an analysis of B‐cell NHL only (with mantle cell NHL excluded), proliferative and apoptotic indices were positively correlated (correlation coefficient = 0.563, P < 0.001). Furthermore, high bcl‐2 expression was inversely correlated with both PI and AI. Expression of p53 was observed in 8 cases (1 small cell lymphoma and 7 large cell lymphomas).
CONCLUSIONS
Small cell lymphomas had low AI and PI values, whereas large cell lymphomas had high AI and PI values. Apoptosis and proliferation were positively correlated, and higher expression of bcl‐2 was associated with lower rates of apoptosis. Cancer 1998;83:158‐165. © 1998 American Cancer Society.
An analysis of the role of proliferation and apoptosis in primary intestinal non‐Hodgkin's lymphoma demonstrated that these cell turnover parameters are different in small and large cell varieties of the disease.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/(SICI)1097-0142(19980701)83:1<158::AID-CNCR21>3.0.CO;2-V</identifier><identifier>PMID: 9655306</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Apoptosis ; bcl‐2 ; Biological and medical sciences ; Cell Division ; classification ; Genes, p53 ; Hematologic and hematopoietic diseases ; Humans ; intestinal lymphoma ; Intestinal Neoplasms - genetics ; Intestinal Neoplasms - pathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma, Non-Hodgkin - genetics ; Lymphoma, Non-Hodgkin - pathology ; Medical sciences ; mucosa‐associated lymphoid tissue ; proliferation ; Proto-Oncogene Proteins c-bcl-2 - analysis ; terminal deoxynucleotidyl transferase‐mediated digoxigenin‐dUTP nick end labeling (TUNEL)</subject><ispartof>Cancer, 1998-07, Vol.83 (1), p.158-165</ispartof><rights>Copyright © 1998 American Cancer Society</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3991-6c72e91f3e43b0e15295e02be2e2ecba864cfa3fc71cdd80885c3adc76c5c0293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-0142%2819980701%2983%3A1%3C158%3A%3AAID-CNCR21%3E3.0.CO%3B2-V$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-0142%2819980701%2983%3A1%3C158%3A%3AAID-CNCR21%3E3.0.CO%3B2-V$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,1432,27923,27924,45573,45574,46408,46832</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2266093$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9655306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gisbertz, Ingrid A. M.</creatorcontrib><creatorcontrib>Schouten, Harry C.</creatorcontrib><creatorcontrib>Bot, Fredrik J</creatorcontrib><creatorcontrib>Arends, Jan‐Willem</creatorcontrib><title>Cell turnover parameters in small and large cell varieties of primary intestinal non‐hodgkin's lymphoma</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
In contrast to primary gastric lymphoma, primary intestinal lymphoma is an uncommon condition with a poorer outcome, perhaps due to differences in its pathogenesis. In this study, the authors analyzed the roles of proliferation and apoptosis in the pathogenesis of intestinal lymphoma.
METHODS
Fifty‐one cases of intestinal non‐Hodgkin's lymphoma (NHL) (10 small B‐cell mucosa‐associated lymphoid tissue [MALT] NHLs, 12 large B‐cell MALT NHLs, 18 large B‐cell NHLs, 2 small T‐cell NHLs, 7 large T‐cell NHLs, and 2 mantle cell NHLs) were studied for the immunohistochemical expression of MIB‐1 and the TUNEL assay as well as the expresssion of bcl‐2 and p53, both of which are regulatory gene products involved in apoptosis.
RESULTS
The median proliferation index (PI) was 37.3%, and the median apoptotic index (AI) was 1.10%. The respective values of PI and AI were 5.8% and 0.06% in small B‐cell MALT lymphoma, 52.8% and 0.24% in large B‐cell MALT lymphoma, 58.85% and 1.36% in large B‐cell lymphoma, 30.9% and 1.93% in mantle cell lymphoma, 18.13% and 1.25% in small T‐cell lymphoma, and 43.4% and 1.93% in large T‐cell lymphoma. In an analysis of B‐cell NHL only (with mantle cell NHL excluded), proliferative and apoptotic indices were positively correlated (correlation coefficient = 0.563, P < 0.001). Furthermore, high bcl‐2 expression was inversely correlated with both PI and AI. Expression of p53 was observed in 8 cases (1 small cell lymphoma and 7 large cell lymphomas).
CONCLUSIONS
Small cell lymphomas had low AI and PI values, whereas large cell lymphomas had high AI and PI values. Apoptosis and proliferation were positively correlated, and higher expression of bcl‐2 was associated with lower rates of apoptosis. Cancer 1998;83:158‐165. © 1998 American Cancer Society.
An analysis of the role of proliferation and apoptosis in primary intestinal non‐Hodgkin's lymphoma demonstrated that these cell turnover parameters are different in small and large cell varieties of the disease.</description><subject>Apoptosis</subject><subject>bcl‐2</subject><subject>Biological and medical sciences</subject><subject>Cell Division</subject><subject>classification</subject><subject>Genes, p53</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>intestinal lymphoma</subject><subject>Intestinal Neoplasms - genetics</subject><subject>Intestinal Neoplasms - pathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma, Non-Hodgkin - genetics</subject><subject>Lymphoma, Non-Hodgkin - pathology</subject><subject>Medical sciences</subject><subject>mucosa‐associated lymphoid tissue</subject><subject>proliferation</subject><subject>Proto-Oncogene Proteins c-bcl-2 - analysis</subject><subject>terminal deoxynucleotidyl transferase‐mediated digoxigenin‐dUTP nick end labeling (TUNEL)</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uEzEUhS0EKiHwCEheIGgXE67tzIwdEKIa_iJVROKnqthcOR5P6zI_wZ4UZccj8Iw8CR5lyAYk5IVl3-Oj4_MR8pLBjAHwp8cfl8XyhIHKE2BzfsyUkpADO5FiwZ6zVC4Wp8tXSfG--MDZCzGDWbF6xpPzW2RyeHSbTABAJulcXNwl90K4jsecp-KIHKksTQVkE-IKW9e03_q2u7GebrTXje2tD9S1NDQ6DnVb0lr7S0vNoL3R3tne2UC7im68a7TfRXFvQ-9aXdO2a3_9-HnVlZdfXfsk0HrXbK66Rt8ndypdB_tg3Kfk85vXn4p3ydnq7bI4PUuMUIolmcm5VawSdi7WYFnKVWqBry2Py6y1zOam0qIyOTNlKUHK1AhdmjwzqQGuxJQ83vtufPdtG1Nh48KQXLe22wbMY5VcxlKm5GIvNL4LwdsKx98gAxwoIA4UcCgUh0LxDwWUAhlGCoiRAu4poEDAYoUcz6P1wzHDdt3Y8mA81h7nj8a5DkbXldetceEg4zzLQIko-7KXfXe13f0V77_p_hluvBG_Afm5s1k</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>Gisbertz, Ingrid A. M.</creator><creator>Schouten, Harry C.</creator><creator>Bot, Fredrik J</creator><creator>Arends, Jan‐Willem</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980701</creationdate><title>Cell turnover parameters in small and large cell varieties of primary intestinal non‐hodgkin's lymphoma</title><author>Gisbertz, Ingrid A. M. ; Schouten, Harry C. ; Bot, Fredrik J ; Arends, Jan‐Willem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3991-6c72e91f3e43b0e15295e02be2e2ecba864cfa3fc71cdd80885c3adc76c5c0293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Apoptosis</topic><topic>bcl‐2</topic><topic>Biological and medical sciences</topic><topic>Cell Division</topic><topic>classification</topic><topic>Genes, p53</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>intestinal lymphoma</topic><topic>Intestinal Neoplasms - genetics</topic><topic>Intestinal Neoplasms - pathology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma, Non-Hodgkin - genetics</topic><topic>Lymphoma, Non-Hodgkin - pathology</topic><topic>Medical sciences</topic><topic>mucosa‐associated lymphoid tissue</topic><topic>proliferation</topic><topic>Proto-Oncogene Proteins c-bcl-2 - analysis</topic><topic>terminal deoxynucleotidyl transferase‐mediated digoxigenin‐dUTP nick end labeling (TUNEL)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gisbertz, Ingrid A. M.</creatorcontrib><creatorcontrib>Schouten, Harry C.</creatorcontrib><creatorcontrib>Bot, Fredrik J</creatorcontrib><creatorcontrib>Arends, Jan‐Willem</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gisbertz, Ingrid A. M.</au><au>Schouten, Harry C.</au><au>Bot, Fredrik J</au><au>Arends, Jan‐Willem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell turnover parameters in small and large cell varieties of primary intestinal non‐hodgkin's lymphoma</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>83</volume><issue>1</issue><spage>158</spage><epage>165</epage><pages>158-165</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND
In contrast to primary gastric lymphoma, primary intestinal lymphoma is an uncommon condition with a poorer outcome, perhaps due to differences in its pathogenesis. In this study, the authors analyzed the roles of proliferation and apoptosis in the pathogenesis of intestinal lymphoma.
METHODS
Fifty‐one cases of intestinal non‐Hodgkin's lymphoma (NHL) (10 small B‐cell mucosa‐associated lymphoid tissue [MALT] NHLs, 12 large B‐cell MALT NHLs, 18 large B‐cell NHLs, 2 small T‐cell NHLs, 7 large T‐cell NHLs, and 2 mantle cell NHLs) were studied for the immunohistochemical expression of MIB‐1 and the TUNEL assay as well as the expresssion of bcl‐2 and p53, both of which are regulatory gene products involved in apoptosis.
RESULTS
The median proliferation index (PI) was 37.3%, and the median apoptotic index (AI) was 1.10%. The respective values of PI and AI were 5.8% and 0.06% in small B‐cell MALT lymphoma, 52.8% and 0.24% in large B‐cell MALT lymphoma, 58.85% and 1.36% in large B‐cell lymphoma, 30.9% and 1.93% in mantle cell lymphoma, 18.13% and 1.25% in small T‐cell lymphoma, and 43.4% and 1.93% in large T‐cell lymphoma. In an analysis of B‐cell NHL only (with mantle cell NHL excluded), proliferative and apoptotic indices were positively correlated (correlation coefficient = 0.563, P < 0.001). Furthermore, high bcl‐2 expression was inversely correlated with both PI and AI. Expression of p53 was observed in 8 cases (1 small cell lymphoma and 7 large cell lymphomas).
CONCLUSIONS
Small cell lymphomas had low AI and PI values, whereas large cell lymphomas had high AI and PI values. Apoptosis and proliferation were positively correlated, and higher expression of bcl‐2 was associated with lower rates of apoptosis. Cancer 1998;83:158‐165. © 1998 American Cancer Society.
An analysis of the role of proliferation and apoptosis in primary intestinal non‐Hodgkin's lymphoma demonstrated that these cell turnover parameters are different in small and large cell varieties of the disease.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>9655306</pmid><doi>10.1002/(SICI)1097-0142(19980701)83:1<158::AID-CNCR21>3.0.CO;2-V</doi><tpages>8</tpages></addata></record> |
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| subjects | Apoptosis bcl‐2 Biological and medical sciences Cell Division classification Genes, p53 Hematologic and hematopoietic diseases Humans intestinal lymphoma Intestinal Neoplasms - genetics Intestinal Neoplasms - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Non-Hodgkin - genetics Lymphoma, Non-Hodgkin - pathology Medical sciences mucosa‐associated lymphoid tissue proliferation Proto-Oncogene Proteins c-bcl-2 - analysis terminal deoxynucleotidyl transferase‐mediated digoxigenin‐dUTP nick end labeling (TUNEL) |
| title | Cell turnover parameters in small and large cell varieties of primary intestinal non‐hodgkin's lymphoma |
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