Coordination of Growth and Cell Division in the Drosophila Wing
In most tissues, cell division is coordinated with increases in mass (i.e., growth). To understand this coordination, we altered rates of division in cell clones or compartments of the Drosophila wing and measured the effects on growth. Constitutive overproduction of the transcriptional regulator dE...
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| Veröffentlicht in: | Cell 1998-06, Vol.93 (7), p.1183-1193 |
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| creator | Neufeld, Thomas P de la Cruz, Aida Flor A Johnston, Laura A Edgar, Bruce A |
| description | In most tissues, cell division is coordinated with increases in mass (i.e., growth). To understand this coordination, we altered rates of division in cell clones or compartments of the
Drosophila wing and measured the effects on growth. Constitutive overproduction of the transcriptional regulator dE2F increased expression of the S- and M-phase initiators Cyclin E and String (Cdc25), thereby accelerating cell proliferation. Loss of dE2F or overproduction of its corepressor, RBF, retarded cell proliferation. These manipulations altered cell numbers over a 4- to 5-fold range but had little effect on clone or compartment sizes. Instead, changes in cell division rates were offset by changes in cell size. We infer that dE2F and RBF function specifically in cell cycle control, and that cell cycle acceleration is insufficient to stimulate growth. Variations in dE2F activity could be used to coordinate cell division with growth. |
| doi_str_mv | 10.1016/S0092-8674(00)81462-2 |
| format | Article |
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Drosophila wing and measured the effects on growth. Constitutive overproduction of the transcriptional regulator dE2F increased expression of the S- and M-phase initiators Cyclin E and String (Cdc25), thereby accelerating cell proliferation. Loss of dE2F or overproduction of its corepressor, RBF, retarded cell proliferation. These manipulations altered cell numbers over a 4- to 5-fold range but had little effect on clone or compartment sizes. Instead, changes in cell division rates were offset by changes in cell size. We infer that dE2F and RBF function specifically in cell cycle control, and that cell cycle acceleration is insufficient to stimulate growth. Variations in dE2F activity could be used to coordinate cell division with growth.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/S0092-8674(00)81462-2</identifier><identifier>PMID: 9657151</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Carrier Proteins ; Cell Cycle - physiology ; Cell Cycle Proteins ; Cell Death ; Cell Division ; Cell Size ; Clone Cells ; Cyclin E - genetics ; Cyclin E - physiology ; DNA - analysis ; DNA-Binding Proteins ; Drosophila melanogaster - embryology ; Drosophila melanogaster - growth & development ; Drosophila Proteins ; E2F Transcription Factors ; Homeodomain Proteins - genetics ; Larva ; Mitosis ; Phosphoprotein Phosphatases - genetics ; Phosphoprotein Phosphatases - physiology ; Protein Tyrosine Phosphatases ; Retinoblastoma Protein ; Retinoblastoma-Binding Protein 1 ; RNA, Messenger - analysis ; S Phase ; Trans-Activators ; Transcription Factors - genetics ; Transcription Factors - physiology ; Transgenes ; Wings, Animal - cytology ; Wings, Animal - growth & development</subject><ispartof>Cell, 1998-06, Vol.93 (7), p.1183-1193</ispartof><rights>1998 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c556t-657626f62150d089bee6fb340af84595e2498b1400c14b2340fb37f9024837bb3</citedby><cites>FETCH-LOGICAL-c556t-657626f62150d089bee6fb340af84595e2498b1400c14b2340fb37f9024837bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0092867400814622$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9657151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Neufeld, Thomas P</creatorcontrib><creatorcontrib>de la Cruz, Aida Flor A</creatorcontrib><creatorcontrib>Johnston, Laura A</creatorcontrib><creatorcontrib>Edgar, Bruce A</creatorcontrib><title>Coordination of Growth and Cell Division in the Drosophila Wing</title><title>Cell</title><addtitle>Cell</addtitle><description>In most tissues, cell division is coordinated with increases in mass (i.e., growth). To understand this coordination, we altered rates of division in cell clones or compartments of the
Drosophila wing and measured the effects on growth. Constitutive overproduction of the transcriptional regulator dE2F increased expression of the S- and M-phase initiators Cyclin E and String (Cdc25), thereby accelerating cell proliferation. Loss of dE2F or overproduction of its corepressor, RBF, retarded cell proliferation. These manipulations altered cell numbers over a 4- to 5-fold range but had little effect on clone or compartment sizes. Instead, changes in cell division rates were offset by changes in cell size. We infer that dE2F and RBF function specifically in cell cycle control, and that cell cycle acceleration is insufficient to stimulate growth. Variations in dE2F activity could be used to coordinate cell division with growth.</description><subject>Animals</subject><subject>Carrier Proteins</subject><subject>Cell Cycle - physiology</subject><subject>Cell Cycle Proteins</subject><subject>Cell Death</subject><subject>Cell Division</subject><subject>Cell Size</subject><subject>Clone Cells</subject><subject>Cyclin E - genetics</subject><subject>Cyclin E - physiology</subject><subject>DNA - analysis</subject><subject>DNA-Binding Proteins</subject><subject>Drosophila melanogaster - embryology</subject><subject>Drosophila melanogaster - growth & development</subject><subject>Drosophila Proteins</subject><subject>E2F Transcription Factors</subject><subject>Homeodomain Proteins - genetics</subject><subject>Larva</subject><subject>Mitosis</subject><subject>Phosphoprotein Phosphatases - genetics</subject><subject>Phosphoprotein Phosphatases - physiology</subject><subject>Protein Tyrosine Phosphatases</subject><subject>Retinoblastoma Protein</subject><subject>Retinoblastoma-Binding Protein 1</subject><subject>RNA, Messenger - analysis</subject><subject>S Phase</subject><subject>Trans-Activators</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - physiology</subject><subject>Transgenes</subject><subject>Wings, Animal - cytology</subject><subject>Wings, Animal - growth & development</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMotVYfoZCV6GL0JM1lsioy1SoUXKi4DHPJ2Mh0UpNpxbc3vdBtV2fx_Sf_yYfQkMAdASLu3wAUTVIh2Q3AbUqYoAk9QX0CSiaMSHqK-ofIOboI4RsAUs55D_WU4JJw0kfjzDlf2TbvrGuxq_HUu99ujvO2wplpGjyxaxs2zLa4mxs88S645dw2Of607dclOqvzJpir_Rygj6fH9-w5mb1OX7KHWVJyLrok1gkqakEJhwpSVRgj6mLEIK9TxhU3lKm0IAygJKygEUQqawWUpSNZFKMBut69u_TuZ2VCpxc2lPHAvDVuFbRUKipg_GiQCE5SKSEG-S5Yxh8Fb2q99HaR-z9NQG8M661hvdGnAfTWsKZxb7gvWBULUx229kojH--4iTrW1ngdSmva0lTWm7LTlbNHGv4BWSKIUw</recordid><startdate>19980626</startdate><enddate>19980626</enddate><creator>Neufeld, Thomas P</creator><creator>de la Cruz, Aida Flor A</creator><creator>Johnston, Laura A</creator><creator>Edgar, Bruce A</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19980626</creationdate><title>Coordination of Growth and Cell Division in the Drosophila Wing</title><author>Neufeld, Thomas P ; de la Cruz, Aida Flor A ; Johnston, Laura A ; Edgar, Bruce A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c556t-657626f62150d089bee6fb340af84595e2498b1400c14b2340fb37f9024837bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Carrier Proteins</topic><topic>Cell Cycle - physiology</topic><topic>Cell Cycle Proteins</topic><topic>Cell Death</topic><topic>Cell Division</topic><topic>Cell Size</topic><topic>Clone Cells</topic><topic>Cyclin E - genetics</topic><topic>Cyclin E - physiology</topic><topic>DNA - analysis</topic><topic>DNA-Binding Proteins</topic><topic>Drosophila melanogaster - embryology</topic><topic>Drosophila melanogaster - growth & development</topic><topic>Drosophila Proteins</topic><topic>E2F Transcription Factors</topic><topic>Homeodomain Proteins - genetics</topic><topic>Larva</topic><topic>Mitosis</topic><topic>Phosphoprotein Phosphatases - genetics</topic><topic>Phosphoprotein Phosphatases - physiology</topic><topic>Protein Tyrosine Phosphatases</topic><topic>Retinoblastoma Protein</topic><topic>Retinoblastoma-Binding Protein 1</topic><topic>RNA, Messenger - analysis</topic><topic>S Phase</topic><topic>Trans-Activators</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - physiology</topic><topic>Transgenes</topic><topic>Wings, Animal - cytology</topic><topic>Wings, Animal - growth & development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neufeld, Thomas P</creatorcontrib><creatorcontrib>de la Cruz, Aida Flor A</creatorcontrib><creatorcontrib>Johnston, Laura A</creatorcontrib><creatorcontrib>Edgar, Bruce A</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neufeld, Thomas P</au><au>de la Cruz, Aida Flor A</au><au>Johnston, Laura A</au><au>Edgar, Bruce A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coordination of Growth and Cell Division in the Drosophila Wing</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>1998-06-26</date><risdate>1998</risdate><volume>93</volume><issue>7</issue><spage>1183</spage><epage>1193</epage><pages>1183-1193</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>In most tissues, cell division is coordinated with increases in mass (i.e., growth). To understand this coordination, we altered rates of division in cell clones or compartments of the
Drosophila wing and measured the effects on growth. Constitutive overproduction of the transcriptional regulator dE2F increased expression of the S- and M-phase initiators Cyclin E and String (Cdc25), thereby accelerating cell proliferation. Loss of dE2F or overproduction of its corepressor, RBF, retarded cell proliferation. These manipulations altered cell numbers over a 4- to 5-fold range but had little effect on clone or compartment sizes. Instead, changes in cell division rates were offset by changes in cell size. We infer that dE2F and RBF function specifically in cell cycle control, and that cell cycle acceleration is insufficient to stimulate growth. Variations in dE2F activity could be used to coordinate cell division with growth.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>9657151</pmid><doi>10.1016/S0092-8674(00)81462-2</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Carrier Proteins Cell Cycle - physiology Cell Cycle Proteins Cell Death Cell Division Cell Size Clone Cells Cyclin E - genetics Cyclin E - physiology DNA - analysis DNA-Binding Proteins Drosophila melanogaster - embryology Drosophila melanogaster - growth & development Drosophila Proteins E2F Transcription Factors Homeodomain Proteins - genetics Larva Mitosis Phosphoprotein Phosphatases - genetics Phosphoprotein Phosphatases - physiology Protein Tyrosine Phosphatases Retinoblastoma Protein Retinoblastoma-Binding Protein 1 RNA, Messenger - analysis S Phase Trans-Activators Transcription Factors - genetics Transcription Factors - physiology Transgenes Wings, Animal - cytology Wings, Animal - growth & development |
| title | Coordination of Growth and Cell Division in the Drosophila Wing |
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