Myc/p53 interactions in transgenic mouse mammary development, tumorigenesis and chromosomal instability

We have examined defects in mammary development and tumorigenesis in a transgenic model expressing the c-myc gene under the MMTV-LTR promoter. The stochastic tumors which arise from hyperplastic ductal and lobular lesions in this model are characterized by high rates both of apoptosis and of chromos...

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Veröffentlicht in:	Oncogene 1998-05, Vol.16 (21), p.2755-2766
Hauptverfasser:	MCCORMACK, S. J, WEAVER, Z, DEMING, S, NATARAJAN, G, TORRI, J, JOHNSON, M. D, LIYANAGE, M, RIED, T, DICKSON, R. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Apoptosis Biological and medical sciences Breast cancer c-Myc protein Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cells, Cultured Chromosome 11 Chromosome aberrations DNA damage Epithelial Cells - cytology Female Fundamental and applied biological sciences. Psychology Gene Expression Genes, myc - genetics Genes, p53 - genetics Genomic instability Genotypes Histology Hyperplasia Karyotyping Latency Lesions Lymphoma Mammary gland Mammary Glands, Animal - growth & development Mammary Glands, Animal - pathology Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - pathology Mammary Tumor Virus, Mouse - genetics Mice Mice, Transgenic Molecular and cellular biology Mutation Myc protein p53 Protein Phenotypes Ploidy Sequence Analysis, DNA Transgenes Transgenic mice Tumorigenesis
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