Treatment of cutaneous and subcutaneous tumors with electrochemotherapy using intralesional bleomycin
BACKGROUND Electrochemotherapy (ECT) is performed by locally administering a chemotherapeutic agent in combination with electric pulses. Previous clinical studies have demonstrated the effectiveness of ECT. In these initial trials, the drug was administered intravenously, followed by administration...
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| Veröffentlicht in: | Cancer 1998-07, Vol.83 (1), p.148-157 |
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| creator | Heller, Richard Jaroszeski, Mark J. Reintgen, Douglas S. Puleo, Chris A. DeConti, Ronald C. Gilbert, Richard A. Glass, Lewis F. |
| description | BACKGROUND
Electrochemotherapy (ECT) is performed by locally administering a chemotherapeutic agent in combination with electric pulses. Previous clinical studies have demonstrated the effectiveness of ECT. In these initial trials, the drug was administered intravenously, followed by administration of electric pulses directly to the tumor. This study was initiated to determine whether an intralesional injection of the drug in combination with electric pulses could provide an improved result. A group of 34 patients was studied.
METHODS
The dose of intralesional bleomycin was based on tumor volume. This was followed 10 minutes later by 6 or 8 99‐μsec pulses of electricity at an amplitude of 1.3 kV/cm. Both the bleomycin and the electric pulses were administered after 1% lidocaine with ephinephrine solution was injected around the treatment site.
RESULTS
All patients responded to the treatment. Responses were observed in 142 (99%) of 143 metastatic nodules or primary tumors within 12 weeks, with complete responses observed in 130 (91%) of the nodules. No complete responses were observed in nodules treated with bleomycin only or electric pulses only. Random biopsies confirmed the clinical findings. All patients tolerated the procedure well, and no significant side effects were noted. Muscle contraction was evident during administration of each electric pulse but promptly subsided after the pulse.
CONCLUSIONS
ECT was shown to be an effective local treatment for cutaneous malignancies. The results suggest that ECT may have a tissue‐sparing effect and result in minimal scarring. ECT may be a suitable alternative therapy for the treatment of basal cell carcinoma, local or regional recurrent melanoma, and other skin cancers. Cancer 1998;83:148‐157. © 1998 American Cancer Society.
A novel method for administering chemotherapeutic agents in the treatment of cutaneous tumors is described. Electrochemotherapy was used successfully in this study to treat basal cell carcinoma, melanoma, and other skin cancers. |
| doi_str_mv | 10.1002/(SICI)1097-0142(19980701)83:1<148::AID-CNCR20>3.0.CO;2-W |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79981384</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79981384</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3990-b5e205e615634accdeebfe7e83f9a00a040ac1419510c4ddd332edc2382594c73</originalsourceid><addsrcrecordid>eNqFkV9r1EAUxQdR6rb1Iwh5EGkfsr0zk9lkVhFL1LpQXNBKiy-XyeTGjeTPOpNQ9ts3S-L6oNCnYe49czhzfoy95zDnAOLi7NsqXZ1z0HEIPBJnXOsEYuDniVzytzxKlsvL1Ycw_ZJ-FfBOzmGert-I8PYJmx0ePWUzAEhCFcm75-zY-1_DNRZKHrEjvVBKgpoxunFkupqaLmiLwPadaajtfWCaPPB99nfQ9XXrfHBfdpuAKrKda-2G6rbbkDPbXdD7svkZlE3nTEW-bBtTBVlFbb2zZXPKnhWm8vRiOk_Y908fb9LP4fX6apVeXodWag1hpkiAogVXCxkZa3OirKCYElloA2AgAmN5xLXiYKM8z6UUlFshE6F0ZGN5wl6PvlvX_u7Jd1iX3lJVjZ_AeKiRyyQahHej0LrWe0cFbl1ZG7dDDrgngLgngPsycV8m_iGAiUSOAwHEgQCOBFAiYLpGgbeD9cspQ5_VlB-Mp8qH_atpb7w1VeFMY0t_kAmxiHmiB9mPUXZfVrT7J96j6f4bbprIBxqeseM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79981384</pqid></control><display><type>article</type><title>Treatment of cutaneous and subcutaneous tumors with electrochemotherapy using intralesional bleomycin</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library (Open Access Collection)</source><source>Alma/SFX Local Collection</source><creator>Heller, Richard ; Jaroszeski, Mark J. ; Reintgen, Douglas S. ; Puleo, Chris A. ; DeConti, Ronald C. ; Gilbert, Richard A. ; Glass, Lewis F.</creator><creatorcontrib>Heller, Richard ; Jaroszeski, Mark J. ; Reintgen, Douglas S. ; Puleo, Chris A. ; DeConti, Ronald C. ; Gilbert, Richard A. ; Glass, Lewis F.</creatorcontrib><description>BACKGROUND
Electrochemotherapy (ECT) is performed by locally administering a chemotherapeutic agent in combination with electric pulses. Previous clinical studies have demonstrated the effectiveness of ECT. In these initial trials, the drug was administered intravenously, followed by administration of electric pulses directly to the tumor. This study was initiated to determine whether an intralesional injection of the drug in combination with electric pulses could provide an improved result. A group of 34 patients was studied.
METHODS
The dose of intralesional bleomycin was based on tumor volume. This was followed 10 minutes later by 6 or 8 99‐μsec pulses of electricity at an amplitude of 1.3 kV/cm. Both the bleomycin and the electric pulses were administered after 1% lidocaine with ephinephrine solution was injected around the treatment site.
RESULTS
All patients responded to the treatment. Responses were observed in 142 (99%) of 143 metastatic nodules or primary tumors within 12 weeks, with complete responses observed in 130 (91%) of the nodules. No complete responses were observed in nodules treated with bleomycin only or electric pulses only. Random biopsies confirmed the clinical findings. All patients tolerated the procedure well, and no significant side effects were noted. Muscle contraction was evident during administration of each electric pulse but promptly subsided after the pulse.
CONCLUSIONS
ECT was shown to be an effective local treatment for cutaneous malignancies. The results suggest that ECT may have a tissue‐sparing effect and result in minimal scarring. ECT may be a suitable alternative therapy for the treatment of basal cell carcinoma, local or regional recurrent melanoma, and other skin cancers. Cancer 1998;83:148‐157. © 1998 American Cancer Society.
A novel method for administering chemotherapeutic agents in the treatment of cutaneous tumors is described. Electrochemotherapy was used successfully in this study to treat basal cell carcinoma, melanoma, and other skin cancers.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/(SICI)1097-0142(19980701)83:1<148::AID-CNCR20>3.0.CO;2-W</identifier><identifier>PMID: 9655305</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Antibiotics, Antineoplastic - therapeutic use ; Antineoplastic agents ; basal cell carcinoma ; Biological and medical sciences ; Bleomycin - therapeutic use ; Carcinoma, Basal Cell - pathology ; Carcinoma, Basal Cell - therapy ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - therapy ; Combined treatments (chemotherapy of immunotherapy associated with an other treatment) ; Electric Stimulation Therapy ; electrochemotherapy and bleomycin ; electroporation ; Female ; Humans ; Kaposi's sarcoma ; Male ; Medical sciences ; melanoma ; Melanoma - pathology ; Melanoma - therapy ; Middle Aged ; Pharmacology. Drug treatments ; Skin Neoplasms - pathology ; Skin Neoplasms - therapy ; squamous cell carcinoma</subject><ispartof>Cancer, 1998-07, Vol.83 (1), p.148-157</ispartof><rights>Copyright © 1998 American Cancer Society</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3990-b5e205e615634accdeebfe7e83f9a00a040ac1419510c4ddd332edc2382594c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-0142%2819980701%2983%3A1%3C148%3A%3AAID-CNCR20%3E3.0.CO%3B2-W$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-0142%2819980701%2983%3A1%3C148%3A%3AAID-CNCR20%3E3.0.CO%3B2-W$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>310,311,315,781,785,790,791,1418,1434,23935,23936,25145,27929,27930,45579,45580,46414,46838</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2267189$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9655305$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heller, Richard</creatorcontrib><creatorcontrib>Jaroszeski, Mark J.</creatorcontrib><creatorcontrib>Reintgen, Douglas S.</creatorcontrib><creatorcontrib>Puleo, Chris A.</creatorcontrib><creatorcontrib>DeConti, Ronald C.</creatorcontrib><creatorcontrib>Gilbert, Richard A.</creatorcontrib><creatorcontrib>Glass, Lewis F.</creatorcontrib><title>Treatment of cutaneous and subcutaneous tumors with electrochemotherapy using intralesional bleomycin</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
Electrochemotherapy (ECT) is performed by locally administering a chemotherapeutic agent in combination with electric pulses. Previous clinical studies have demonstrated the effectiveness of ECT. In these initial trials, the drug was administered intravenously, followed by administration of electric pulses directly to the tumor. This study was initiated to determine whether an intralesional injection of the drug in combination with electric pulses could provide an improved result. A group of 34 patients was studied.
METHODS
The dose of intralesional bleomycin was based on tumor volume. This was followed 10 minutes later by 6 or 8 99‐μsec pulses of electricity at an amplitude of 1.3 kV/cm. Both the bleomycin and the electric pulses were administered after 1% lidocaine with ephinephrine solution was injected around the treatment site.
RESULTS
All patients responded to the treatment. Responses were observed in 142 (99%) of 143 metastatic nodules or primary tumors within 12 weeks, with complete responses observed in 130 (91%) of the nodules. No complete responses were observed in nodules treated with bleomycin only or electric pulses only. Random biopsies confirmed the clinical findings. All patients tolerated the procedure well, and no significant side effects were noted. Muscle contraction was evident during administration of each electric pulse but promptly subsided after the pulse.
CONCLUSIONS
ECT was shown to be an effective local treatment for cutaneous malignancies. The results suggest that ECT may have a tissue‐sparing effect and result in minimal scarring. ECT may be a suitable alternative therapy for the treatment of basal cell carcinoma, local or regional recurrent melanoma, and other skin cancers. Cancer 1998;83:148‐157. © 1998 American Cancer Society.
A novel method for administering chemotherapeutic agents in the treatment of cutaneous tumors is described. Electrochemotherapy was used successfully in this study to treat basal cell carcinoma, melanoma, and other skin cancers.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibiotics, Antineoplastic - therapeutic use</subject><subject>Antineoplastic agents</subject><subject>basal cell carcinoma</subject><subject>Biological and medical sciences</subject><subject>Bleomycin - therapeutic use</subject><subject>Carcinoma, Basal Cell - pathology</subject><subject>Carcinoma, Basal Cell - therapy</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</subject><subject>Electric Stimulation Therapy</subject><subject>electrochemotherapy and bleomycin</subject><subject>electroporation</subject><subject>Female</subject><subject>Humans</subject><subject>Kaposi's sarcoma</subject><subject>Male</subject><subject>Medical sciences</subject><subject>melanoma</subject><subject>Melanoma - pathology</subject><subject>Melanoma - therapy</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - therapy</subject><subject>squamous cell carcinoma</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9r1EAUxQdR6rb1Iwh5EGkfsr0zk9lkVhFL1LpQXNBKiy-XyeTGjeTPOpNQ9ts3S-L6oNCnYe49czhzfoy95zDnAOLi7NsqXZ1z0HEIPBJnXOsEYuDniVzytzxKlsvL1Ycw_ZJ-FfBOzmGert-I8PYJmx0ePWUzAEhCFcm75-zY-1_DNRZKHrEjvVBKgpoxunFkupqaLmiLwPadaajtfWCaPPB99nfQ9XXrfHBfdpuAKrKda-2G6rbbkDPbXdD7svkZlE3nTEW-bBtTBVlFbb2zZXPKnhWm8vRiOk_Y908fb9LP4fX6apVeXodWag1hpkiAogVXCxkZa3OirKCYElloA2AgAmN5xLXiYKM8z6UUlFshE6F0ZGN5wl6PvlvX_u7Jd1iX3lJVjZ_AeKiRyyQahHej0LrWe0cFbl1ZG7dDDrgngLgngPsycV8m_iGAiUSOAwHEgQCOBFAiYLpGgbeD9cspQ5_VlB-Mp8qH_atpb7w1VeFMY0t_kAmxiHmiB9mPUXZfVrT7J96j6f4bbprIBxqeseM</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>Heller, Richard</creator><creator>Jaroszeski, Mark J.</creator><creator>Reintgen, Douglas S.</creator><creator>Puleo, Chris A.</creator><creator>DeConti, Ronald C.</creator><creator>Gilbert, Richard A.</creator><creator>Glass, Lewis F.</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980701</creationdate><title>Treatment of cutaneous and subcutaneous tumors with electrochemotherapy using intralesional bleomycin</title><author>Heller, Richard ; Jaroszeski, Mark J. ; Reintgen, Douglas S. ; Puleo, Chris A. ; DeConti, Ronald C. ; Gilbert, Richard A. ; Glass, Lewis F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3990-b5e205e615634accdeebfe7e83f9a00a040ac1419510c4ddd332edc2382594c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibiotics, Antineoplastic - therapeutic use</topic><topic>Antineoplastic agents</topic><topic>basal cell carcinoma</topic><topic>Biological and medical sciences</topic><topic>Bleomycin - therapeutic use</topic><topic>Carcinoma, Basal Cell - pathology</topic><topic>Carcinoma, Basal Cell - therapy</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</topic><topic>Electric Stimulation Therapy</topic><topic>electrochemotherapy and bleomycin</topic><topic>electroporation</topic><topic>Female</topic><topic>Humans</topic><topic>Kaposi's sarcoma</topic><topic>Male</topic><topic>Medical sciences</topic><topic>melanoma</topic><topic>Melanoma - pathology</topic><topic>Melanoma - therapy</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - therapy</topic><topic>squamous cell carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heller, Richard</creatorcontrib><creatorcontrib>Jaroszeski, Mark J.</creatorcontrib><creatorcontrib>Reintgen, Douglas S.</creatorcontrib><creatorcontrib>Puleo, Chris A.</creatorcontrib><creatorcontrib>DeConti, Ronald C.</creatorcontrib><creatorcontrib>Gilbert, Richard A.</creatorcontrib><creatorcontrib>Glass, Lewis F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heller, Richard</au><au>Jaroszeski, Mark J.</au><au>Reintgen, Douglas S.</au><au>Puleo, Chris A.</au><au>DeConti, Ronald C.</au><au>Gilbert, Richard A.</au><au>Glass, Lewis F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of cutaneous and subcutaneous tumors with electrochemotherapy using intralesional bleomycin</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>83</volume><issue>1</issue><spage>148</spage><epage>157</epage><pages>148-157</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND
Electrochemotherapy (ECT) is performed by locally administering a chemotherapeutic agent in combination with electric pulses. Previous clinical studies have demonstrated the effectiveness of ECT. In these initial trials, the drug was administered intravenously, followed by administration of electric pulses directly to the tumor. This study was initiated to determine whether an intralesional injection of the drug in combination with electric pulses could provide an improved result. A group of 34 patients was studied.
METHODS
The dose of intralesional bleomycin was based on tumor volume. This was followed 10 minutes later by 6 or 8 99‐μsec pulses of electricity at an amplitude of 1.3 kV/cm. Both the bleomycin and the electric pulses were administered after 1% lidocaine with ephinephrine solution was injected around the treatment site.
RESULTS
All patients responded to the treatment. Responses were observed in 142 (99%) of 143 metastatic nodules or primary tumors within 12 weeks, with complete responses observed in 130 (91%) of the nodules. No complete responses were observed in nodules treated with bleomycin only or electric pulses only. Random biopsies confirmed the clinical findings. All patients tolerated the procedure well, and no significant side effects were noted. Muscle contraction was evident during administration of each electric pulse but promptly subsided after the pulse.
CONCLUSIONS
ECT was shown to be an effective local treatment for cutaneous malignancies. The results suggest that ECT may have a tissue‐sparing effect and result in minimal scarring. ECT may be a suitable alternative therapy for the treatment of basal cell carcinoma, local or regional recurrent melanoma, and other skin cancers. Cancer 1998;83:148‐157. © 1998 American Cancer Society.
A novel method for administering chemotherapeutic agents in the treatment of cutaneous tumors is described. Electrochemotherapy was used successfully in this study to treat basal cell carcinoma, melanoma, and other skin cancers.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>9655305</pmid><doi>10.1002/(SICI)1097-0142(19980701)83:1<148::AID-CNCR20>3.0.CO;2-W</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Aged Antibiotics, Antineoplastic - therapeutic use Antineoplastic agents basal cell carcinoma Biological and medical sciences Bleomycin - therapeutic use Carcinoma, Basal Cell - pathology Carcinoma, Basal Cell - therapy Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Electric Stimulation Therapy electrochemotherapy and bleomycin electroporation Female Humans Kaposi's sarcoma Male Medical sciences melanoma Melanoma - pathology Melanoma - therapy Middle Aged Pharmacology. Drug treatments Skin Neoplasms - pathology Skin Neoplasms - therapy squamous cell carcinoma |
| title | Treatment of cutaneous and subcutaneous tumors with electrochemotherapy using intralesional bleomycin |
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