Footshock-induced rise of rat blood histamine depends upon the activation of postganglionic sympathetic neurons
We have previously shown the existence of a novel peripheral reflex inhibitorily modulating the vas deferens sympathetic activity. An interaction between noradrenergic and histamine-containing neurons is involved in this reflex. As an overall mechanism of sympathetic autoregulation, we found that en...
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| Veröffentlicht in: | European journal of pharmacology 1998-04, Vol.347 (2), p.159-164 |
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| container_title | European journal of pharmacology |
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| creator | Campos, H.Augusto Montenegro, Martha |
| description | We have previously shown the existence of a novel peripheral reflex inhibitorily modulating the vas deferens sympathetic activity. An interaction between noradrenergic and histamine-containing neurons is involved in this reflex. As an overall mechanism of sympathetic autoregulation, we found that enhanced sympathetic activity in the rat during the stress induced by brief inescapable footshocks caused a marked rise of blood histamine that was seemingly dependent upon sympathetic activity. This rise was prevented by either previous ganglionic blockade with hexamethonium or chronic guanethidine-induced sympathectomy. Previous adrenal demedullation did not impair this rise. Thus, it appears that only the sympathetic postganglionic neuron, interacting with a histamine-containing neuron, is involved in the rise of blood histamine induced by footshocks. |
| doi_str_mv | 10.1016/S0014-2999(98)00097-1 |
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An interaction between noradrenergic and histamine-containing neurons is involved in this reflex. As an overall mechanism of sympathetic autoregulation, we found that enhanced sympathetic activity in the rat during the stress induced by brief inescapable footshocks caused a marked rise of blood histamine that was seemingly dependent upon sympathetic activity. This rise was prevented by either previous ganglionic blockade with hexamethonium or chronic guanethidine-induced sympathectomy. Previous adrenal demedullation did not impair this rise. Thus, it appears that only the sympathetic postganglionic neuron, interacting with a histamine-containing neuron, is involved in the rise of blood histamine induced by footshocks.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/S0014-2999(98)00097-1</identifier><identifier>PMID: 9653876</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adrenal Medulla - physiology ; Adrenergic Agents - pharmacology ; Animals ; Antihypertensive agents ; Biological and medical sciences ; Blood ; Cardiovascular system ; Electric Stimulation ; Ganglia, Sympathetic - drug effects ; Ganglia, Sympathetic - metabolism ; Ganglionic Blockers - pharmacology ; Guanethidine - pharmacology ; Hexamethonium - pharmacology ; Histamine ; Histamine - blood ; Male ; Medical sciences ; Neuronal ; Neurons - drug effects ; Neurons - metabolism ; Noradrenergic neuron ; Peripheral ; Pharmacology. Drug treatments ; Rats ; Rats, Sprague-Dawley ; Reflex ; Stress ; Stress, Physiological - blood ; Sympathectomy ; Sympathetic autoregulation ; Time Factors</subject><ispartof>European journal of pharmacology, 1998-04, Vol.347 (2), p.159-164</ispartof><rights>1998 Elsevier Science B.V.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-7c8aaa8cdfb521e13d3ede7494c5d7f3f55ef1839e41a88ebf2ef32eee5582f53</citedby><cites>FETCH-LOGICAL-c455t-7c8aaa8cdfb521e13d3ede7494c5d7f3f55ef1839e41a88ebf2ef32eee5582f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0014-2999(98)00097-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2305209$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9653876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Campos, H.Augusto</creatorcontrib><creatorcontrib>Montenegro, Martha</creatorcontrib><title>Footshock-induced rise of rat blood histamine depends upon the activation of postganglionic sympathetic neurons</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>We have previously shown the existence of a novel peripheral reflex inhibitorily modulating the vas deferens sympathetic activity. An interaction between noradrenergic and histamine-containing neurons is involved in this reflex. As an overall mechanism of sympathetic autoregulation, we found that enhanced sympathetic activity in the rat during the stress induced by brief inescapable footshocks caused a marked rise of blood histamine that was seemingly dependent upon sympathetic activity. This rise was prevented by either previous ganglionic blockade with hexamethonium or chronic guanethidine-induced sympathectomy. Previous adrenal demedullation did not impair this rise. Thus, it appears that only the sympathetic postganglionic neuron, interacting with a histamine-containing neuron, is involved in the rise of blood histamine induced by footshocks.</description><subject>Adrenal Medulla - physiology</subject><subject>Adrenergic Agents - pharmacology</subject><subject>Animals</subject><subject>Antihypertensive agents</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Cardiovascular system</subject><subject>Electric Stimulation</subject><subject>Ganglia, Sympathetic - drug effects</subject><subject>Ganglia, Sympathetic - metabolism</subject><subject>Ganglionic Blockers - pharmacology</subject><subject>Guanethidine - pharmacology</subject><subject>Hexamethonium - pharmacology</subject><subject>Histamine</subject><subject>Histamine - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuronal</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Noradrenergic neuron</subject><subject>Peripheral</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reflex</subject><subject>Stress</subject><subject>Stress, Physiological - blood</subject><subject>Sympathectomy</subject><subject>Sympathetic autoregulation</subject><subject>Time Factors</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvFCEUx4nR1G31IzThYIweRoEZduBkTGOrSRMP6pmw8OiiMzDymCb99tLuZq-eeC_v9wfye4RccvaBM779-IMxPnRCa_1Oq_eMMT12_BnZcDXqjo1cPCebE_KSnCP-bpDUQp6RM72VvRq3G5Kvc664z-5PF5NfHXhaIgLNgRZb6W7K2dN9xGrnmIB6WCB5pOuSE617oNbVeG9rbG2LLBnrnU13U-ujo_gwL7ZRtdUJ1pITviIvgp0QXh_PC_Lr-svPq6_d7febb1efbzs3SFm70SlrrXI-7KTgwHvfg4dx0IOTfgx9kBICV72GgVulYBcEhF4AgJRKBNlfkLeHe5eS_66A1cwRHUyTTZBXNKPWinOxbaA8gK5kxALBLCXOtjwYzsyjaPMk2jxaNFqZJ9GGt9zl8YF1N4M_pY5m2_zNcW7R2SkUm1zEEyZ6JgXTDft0wKDJuI9QDLoIqe0hFnDV-Bz_85F_S7GdmA</recordid><startdate>19980424</startdate><enddate>19980424</enddate><creator>Campos, H.Augusto</creator><creator>Montenegro, Martha</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980424</creationdate><title>Footshock-induced rise of rat blood histamine depends upon the activation of postganglionic sympathetic neurons</title><author>Campos, H.Augusto ; Montenegro, Martha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-7c8aaa8cdfb521e13d3ede7494c5d7f3f55ef1839e41a88ebf2ef32eee5582f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adrenal Medulla - physiology</topic><topic>Adrenergic Agents - pharmacology</topic><topic>Animals</topic><topic>Antihypertensive agents</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Cardiovascular system</topic><topic>Electric Stimulation</topic><topic>Ganglia, Sympathetic - drug effects</topic><topic>Ganglia, Sympathetic - metabolism</topic><topic>Ganglionic Blockers - pharmacology</topic><topic>Guanethidine - pharmacology</topic><topic>Hexamethonium - pharmacology</topic><topic>Histamine</topic><topic>Histamine - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuronal</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Noradrenergic neuron</topic><topic>Peripheral</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reflex</topic><topic>Stress</topic><topic>Stress, Physiological - blood</topic><topic>Sympathectomy</topic><topic>Sympathetic autoregulation</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Campos, H.Augusto</creatorcontrib><creatorcontrib>Montenegro, Martha</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Campos, H.Augusto</au><au>Montenegro, Martha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Footshock-induced rise of rat blood histamine depends upon the activation of postganglionic sympathetic neurons</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1998-04-24</date><risdate>1998</risdate><volume>347</volume><issue>2</issue><spage>159</spage><epage>164</epage><pages>159-164</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>We have previously shown the existence of a novel peripheral reflex inhibitorily modulating the vas deferens sympathetic activity. An interaction between noradrenergic and histamine-containing neurons is involved in this reflex. As an overall mechanism of sympathetic autoregulation, we found that enhanced sympathetic activity in the rat during the stress induced by brief inescapable footshocks caused a marked rise of blood histamine that was seemingly dependent upon sympathetic activity. This rise was prevented by either previous ganglionic blockade with hexamethonium or chronic guanethidine-induced sympathectomy. Previous adrenal demedullation did not impair this rise. Thus, it appears that only the sympathetic postganglionic neuron, interacting with a histamine-containing neuron, is involved in the rise of blood histamine induced by footshocks.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>9653876</pmid><doi>10.1016/S0014-2999(98)00097-1</doi><tpages>6</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 1998-04, Vol.347 (2), p.159-164 |
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| subjects | Adrenal Medulla - physiology Adrenergic Agents - pharmacology Animals Antihypertensive agents Biological and medical sciences Blood Cardiovascular system Electric Stimulation Ganglia, Sympathetic - drug effects Ganglia, Sympathetic - metabolism Ganglionic Blockers - pharmacology Guanethidine - pharmacology Hexamethonium - pharmacology Histamine Histamine - blood Male Medical sciences Neuronal Neurons - drug effects Neurons - metabolism Noradrenergic neuron Peripheral Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Reflex Stress Stress, Physiological - blood Sympathectomy Sympathetic autoregulation Time Factors |
| title | Footshock-induced rise of rat blood histamine depends upon the activation of postganglionic sympathetic neurons |
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