Distribution of cardiac output during pentobarbital versus midazolam/fentanyl/fluanisone anaesthesia in the rat
Differences in effects on central haemodynamics, organ blood flow, and serum corticosterone were studied in 11 rats anaesthetized with midazolam/fentanyl/fluanisone (MFF) and 11 other rats anaesthetized with sodium pentobarbital. Compared with pentobarbital, MFF reduced aortic blood pressure by 25%,...
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| Veröffentlicht in: | Laboratory animals (London) 1990-07, Vol.24 (3), p.221-227 |
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| creator | Skolleborg, K.C Gronbech, J.E Grong, K Abyholm, F.E Lekven, J |
| description | Differences in effects on central haemodynamics, organ blood flow, and serum corticosterone were studied in 11 rats anaesthetized with midazolam/fentanyl/fluanisone (MFF) and 11 other rats anaesthetized with sodium pentobarbital. Compared with pentobarbital, MFF reduced aortic blood pressure by 25%, increased heart rate by 20%, and increased cardiae output by 80%. Unlike most tissues, MFF produced a fivefold increase in blood flow to skeletal muscle, and decreased adrenal blood flow compared to pentobarbital anaesthesia. Initial serum corticosterone levels were lower in rats given MFF anaesthesia, indicating better stress protection. This study also indicates that MFF anaesthesia is preferable to pentobarbital because tissue perfusion generally was better preserved. |
| doi_str_mv | 10.1258/002367790780866100 |
| format | Article |
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Compared with pentobarbital, MFF reduced aortic blood pressure by 25%, increased heart rate by 20%, and increased cardiae output by 80%. Unlike most tissues, MFF produced a fivefold increase in blood flow to skeletal muscle, and decreased adrenal blood flow compared to pentobarbital anaesthesia. Initial serum corticosterone levels were lower in rats given MFF anaesthesia, indicating better stress protection. This study also indicates that MFF anaesthesia is preferable to pentobarbital because tissue perfusion generally was better preserved.</description><identifier>ISSN: 0023-6772</identifier><identifier>EISSN: 1758-1117</identifier><identifier>DOI: 10.1258/002367790780866100</identifier><identifier>PMID: 2144326</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>anesthesia ; Anesthesia - veterinary ; Animals ; Butyrophenones - pharmacology ; Cardiac Output - drug effects ; Corticosterone - blood ; Fentanyl - pharmacology ; Hemodynamics - drug effects ; Hemoglobins - analysis ; Injections, Intraperitoneal - veterinary ; Injections, Subcutaneous - veterinary ; Male ; Midazolam - pharmacology ; Pentobarbital - pharmacology ; Random Allocation ; Rats ; Regional Blood Flow - drug effects ; Specific Pathogen-Free Organisms</subject><ispartof>Laboratory animals (London), 1990-07, Vol.24 (3), p.221-227</ispartof><rights>1990 Royal Society of Medicine Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-2f7b4f2c9b44ed87d483007b71e0b88a3f5a9a9d45c9b2a344a17a6598a234d03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2144326$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Skolleborg, K.C</creatorcontrib><creatorcontrib>Gronbech, J.E</creatorcontrib><creatorcontrib>Grong, K</creatorcontrib><creatorcontrib>Abyholm, F.E</creatorcontrib><creatorcontrib>Lekven, J</creatorcontrib><title>Distribution of cardiac output during pentobarbital versus midazolam/fentanyl/fluanisone anaesthesia in the rat</title><title>Laboratory animals (London)</title><addtitle>Lab Anim</addtitle><description>Differences in effects on central haemodynamics, organ blood flow, and serum corticosterone were studied in 11 rats anaesthetized with midazolam/fentanyl/fluanisone (MFF) and 11 other rats anaesthetized with sodium pentobarbital. Compared with pentobarbital, MFF reduced aortic blood pressure by 25%, increased heart rate by 20%, and increased cardiae output by 80%. Unlike most tissues, MFF produced a fivefold increase in blood flow to skeletal muscle, and decreased adrenal blood flow compared to pentobarbital anaesthesia. Initial serum corticosterone levels were lower in rats given MFF anaesthesia, indicating better stress protection. This study also indicates that MFF anaesthesia is preferable to pentobarbital because tissue perfusion generally was better preserved.</description><subject>anesthesia</subject><subject>Anesthesia - veterinary</subject><subject>Animals</subject><subject>Butyrophenones - pharmacology</subject><subject>Cardiac Output - drug effects</subject><subject>Corticosterone - blood</subject><subject>Fentanyl - pharmacology</subject><subject>Hemodynamics - drug effects</subject><subject>Hemoglobins - analysis</subject><subject>Injections, Intraperitoneal - veterinary</subject><subject>Injections, Subcutaneous - veterinary</subject><subject>Male</subject><subject>Midazolam - pharmacology</subject><subject>Pentobarbital - pharmacology</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Regional Blood Flow - drug effects</subject><subject>Specific Pathogen-Free Organisms</subject><issn>0023-6772</issn><issn>1758-1117</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1rFTEUxYNU2mf1HxCkWbkbX75mkiylrbZQcKFdhzszyTNlJnnNh1D_elPeoxuhq3sv53cOyUHoIyVfKOvVlhDGByk1kYqoYaCEvEEbKnvVUUrlCdo8A10j2Bl6l_NDO6lQ5BSdtik4GzYoXvlckh9r8THg6PAEafYw4VjLvhY81-TDDu9tKHGENPoCC_5jU64Zr36Gv3GBdeuaDOFp2bqlQvA5BoshgM3lt80esA-4bThBeY_eOliy_XCc5-j-2_Wvy5vu7sf328uvd90kyFA65uQoHJv0KISdlZyF4oTIUVJLRqWAux406Fn0DWHAhQAqYei1AsbFTPg5-nzI3af4WNtDzOrzZJcFgo01G6m11IOmDWQHcEox52Sd2Se_QnoylJjnls3_LTfTp2N6HVc7v1iOtTZ9e9Az7Kx5iDWF9tnXEy8ODgfRwC75bO5_MkI5oVIqQST_B9dfkDo</recordid><startdate>19900701</startdate><enddate>19900701</enddate><creator>Skolleborg, K.C</creator><creator>Gronbech, J.E</creator><creator>Grong, K</creator><creator>Abyholm, F.E</creator><creator>Lekven, J</creator><general>SAGE Publications</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900701</creationdate><title>Distribution of cardiac output during pentobarbital versus midazolam/fentanyl/fluanisone anaesthesia in the rat</title><author>Skolleborg, K.C ; Gronbech, J.E ; Grong, K ; Abyholm, F.E ; Lekven, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-2f7b4f2c9b44ed87d483007b71e0b88a3f5a9a9d45c9b2a344a17a6598a234d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>anesthesia</topic><topic>Anesthesia - veterinary</topic><topic>Animals</topic><topic>Butyrophenones - pharmacology</topic><topic>Cardiac Output - drug effects</topic><topic>Corticosterone - blood</topic><topic>Fentanyl - pharmacology</topic><topic>Hemodynamics - drug effects</topic><topic>Hemoglobins - analysis</topic><topic>Injections, Intraperitoneal - veterinary</topic><topic>Injections, Subcutaneous - veterinary</topic><topic>Male</topic><topic>Midazolam - pharmacology</topic><topic>Pentobarbital - pharmacology</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Regional Blood Flow - drug effects</topic><topic>Specific Pathogen-Free Organisms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Skolleborg, K.C</creatorcontrib><creatorcontrib>Gronbech, J.E</creatorcontrib><creatorcontrib>Grong, K</creatorcontrib><creatorcontrib>Abyholm, F.E</creatorcontrib><creatorcontrib>Lekven, J</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Laboratory animals (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Skolleborg, K.C</au><au>Gronbech, J.E</au><au>Grong, K</au><au>Abyholm, F.E</au><au>Lekven, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of cardiac output during pentobarbital versus midazolam/fentanyl/fluanisone anaesthesia in the rat</atitle><jtitle>Laboratory animals (London)</jtitle><addtitle>Lab Anim</addtitle><date>1990-07-01</date><risdate>1990</risdate><volume>24</volume><issue>3</issue><spage>221</spage><epage>227</epage><pages>221-227</pages><issn>0023-6772</issn><eissn>1758-1117</eissn><abstract>Differences in effects on central haemodynamics, organ blood flow, and serum corticosterone were studied in 11 rats anaesthetized with midazolam/fentanyl/fluanisone (MFF) and 11 other rats anaesthetized with sodium pentobarbital. Compared with pentobarbital, MFF reduced aortic blood pressure by 25%, increased heart rate by 20%, and increased cardiae output by 80%. Unlike most tissues, MFF produced a fivefold increase in blood flow to skeletal muscle, and decreased adrenal blood flow compared to pentobarbital anaesthesia. Initial serum corticosterone levels were lower in rats given MFF anaesthesia, indicating better stress protection. This study also indicates that MFF anaesthesia is preferable to pentobarbital because tissue perfusion generally was better preserved.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>2144326</pmid><doi>10.1258/002367790780866100</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0023-6772 |
| ispartof | Laboratory animals (London), 1990-07, Vol.24 (3), p.221-227 |
| issn | 0023-6772 1758-1117 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | anesthesia Anesthesia - veterinary Animals Butyrophenones - pharmacology Cardiac Output - drug effects Corticosterone - blood Fentanyl - pharmacology Hemodynamics - drug effects Hemoglobins - analysis Injections, Intraperitoneal - veterinary Injections, Subcutaneous - veterinary Male Midazolam - pharmacology Pentobarbital - pharmacology Random Allocation Rats Regional Blood Flow - drug effects Specific Pathogen-Free Organisms |
| title | Distribution of cardiac output during pentobarbital versus midazolam/fentanyl/fluanisone anaesthesia in the rat |
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