Development and evaluation of a monolithic drug-in-adhesive patch for valsartan

The purpose of this study was to investigate the feasibility of a monolithic drug-in-adhesive (DIA) patch as a transdermal therapeutic system for the administration of valsartan (VAL). To improve the penetration of VAL in the patch, several chemical penetration enhancers were investigated by in vitr...

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Veröffentlicht in:	International journal of pharmaceutics 2010-12, Vol.402 (1), p.103-109
Hauptverfasser:	Nishida, Naohiro, Taniyama, Kazuhiro, Sawabe, Toshihiro, Manome, Yoichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Angiotensin II Type 1 Receptor Blockers - administration & dosage Angiotensin II Type 1 Receptor Blockers - pharmacokinetics Animals Biological and medical sciences Diisooctyl sodium sulfosuccinate Dioctyl Sulfosuccinic Acid - chemistry Drug-in-adhesive patch Excipients - chemistry Female General pharmacology Humans Male Medical sciences Mice Mice, Hairless Myristates - chemistry Permeability Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rats Rats, Hairless Skin Absorption Species Specificity Swine Swine, Miniature Tetrazoles - administration & dosage Tetrazoles - pharmacokinetics Transdermal Transdermal Patch Valine - administration & dosage Valine - analogs & derivatives Valine - pharmacokinetics Valsartan Yucatan micro pig
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