Regioselective syntheses of sulfated polysaccharides: specific anti-HIV-1 activity of novel chitin sulfates

A novel and convenient method for the regioselective syntheses of sulfated analogs of chitin and chitosan is described in relation to studies on structure–biological activity. Fully protected, soluble derivatives of chitosan were found to be useful intermediates for the syntheses of a novel class of...

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Veröffentlicht in:	Carbohydrate research 1998, Vol.306 (3), p.427-433
Hauptverfasser:	Nishimura, Shin-Ichiro, Kai, Hideaki, Shinada, Katsuhiko, Yoshida, Takashi, Tokura, Seiichi, Kurita, Keisuke, Nakashima, Hideki, Yamamoto, Naoki, Uryu, Toshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Anti-HIV Anti-HIV Agents - chemical synthesis Anticoagulants - chemical synthesis Antiviral Agents - chemical synthesis Chitin Chitin - analogs & derivatives Chitin - chemistry Chitin - pharmacology Chitin sulfates Chitosan Decapoda (Crustacea) HIV Envelope Protein gp120 - metabolism Oligosaccharides - chemical synthesis Oligosaccharides - pharmacology Regioselective modifications Sulfates - chemical synthesis Sulfates - pharmacology T-Lymphocytes - virology X-Ray Diffraction
Online-Zugang:	Volltext
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