Effect of Granulocyte Colony-Stimulating Factor after Intensive Induction Therapy in Relapsed or Refractory Acute Leukemia
THROUGH recent progress in chemotherapy and bone marrow transplantation, acute leukemia has become a curable disease. It has become clear, however, that intensive therapy is required to effect a cure, especially in acute myelogenous leukemia. 1 2 3 Myelosuppression from therapy and the infections th...
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| Veröffentlicht in: | The New England journal of medicine 1990-09, Vol.323 (13), p.871-877 |
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| creator | Ohno, Ryuzo Tomonaga, Masao Kobayashi, Tohru Kanamaru, Akihisa Shirakawa, Shigeru Masaoka, Tohru Omine, Mitsuhiro Oh, Hakumei Nomura, Takeo Sakai, Yasunobu Hirano, Masami Yokomaku, Shozo Nakayama, Shiro Yoshida, Yutaka Miura, Akira B Morishima, Yasuo Dohy, Hiroo Niho, Yoshiyuki Hamajima, Nobuyuki Takaku, Fumimaro |
| description | THROUGH recent progress in chemotherapy and bone marrow transplantation, acute leukemia has become a curable disease. It has become clear, however, that intensive therapy is required to effect a cure, especially in acute myelogenous leukemia.
1
2
3
Myelosuppression from therapy and the infections that result have been the major obstacles in the treatment of acute leukemia.
Recently, colony-stimulating factors have been molecularly cloned and produced in sufficient quantities to allow their use in clinical trials.
4
Recombinant human granulocyte colony-stimulating factor (CSF) and granulocytemacrophage CSF are two of the factors that have been shown to increase the production of neutrophils in healthy volunteers . . . |
| doi_str_mv | 10.1056/NEJM199009273231304 |
| format | Article |
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1
2
3
Myelosuppression from therapy and the infections that result have been the major obstacles in the treatment of acute leukemia.
Recently, colony-stimulating factors have been molecularly cloned and produced in sufficient quantities to allow their use in clinical trials.
4
Recombinant human granulocyte colony-stimulating factor (CSF) and granulocytemacrophage CSF are two of the factors that have been shown to increase the production of neutrophils in healthy volunteers . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199009273231304</identifier><identifier>PMID: 1697646</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Acute Disease ; Acute myeloid leukemia ; Adolescent ; Adult ; Aged ; Blast crisis ; Bone marrow ; Bone Marrow - pathology ; Bone marrow transplantation ; Chemotherapy ; Chronic myeloid leukemia ; Colonies ; Colonies & territories ; Colony-stimulating factor ; Colony-Stimulating Factors - adverse effects ; Colony-Stimulating Factors - therapeutic use ; Drug dosages ; Female ; Granulocyte Colony-Stimulating Factor ; Granulocytes ; Hospitals ; Humans ; Induction therapy ; Infection Control ; Leukemia ; Leukemia - complications ; Leukemia - therapy ; Leukocyte Count ; Leukocytes (granulocytic) ; Leukocytes (neutrophilic) ; Male ; Middle Aged ; Myelodysplastic syndrome ; Myeloid leukemia ; Neutropenia ; Neutropenia - therapy ; Neutrophils ; Preventive medicine ; Prospective Studies ; Randomized Controlled Trials as Topic ; Recombinant Proteins - adverse effects ; Recombinant Proteins - therapeutic use ; Recurrence ; Remission ; Remission Induction ; Statistical analysis ; Transplantation ; Transplants & implants</subject><ispartof>The New England journal of medicine, 1990-09, Vol.323 (13), p.871-877</ispartof><rights>Copyright Massachusetts Medical Society Sep 27, 1990</rights><rights>Copyright Massachusetts Medical Society, Publishing Division Sep 27, 1990</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-d54544806d8f5b234f2905484495cd56f048f3020049e0a9b9a1ea559d8d5e413</citedby><cites>FETCH-LOGICAL-c505t-d54544806d8f5b234f2905484495cd56f048f3020049e0a9b9a1ea559d8d5e413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199009273231304$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1983424233?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,2760,2761,26108,27929,27930,52387,54069,64390,64392,64394,72474</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1697646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohno, Ryuzo</creatorcontrib><creatorcontrib>Tomonaga, Masao</creatorcontrib><creatorcontrib>Kobayashi, Tohru</creatorcontrib><creatorcontrib>Kanamaru, Akihisa</creatorcontrib><creatorcontrib>Shirakawa, Shigeru</creatorcontrib><creatorcontrib>Masaoka, Tohru</creatorcontrib><creatorcontrib>Omine, Mitsuhiro</creatorcontrib><creatorcontrib>Oh, Hakumei</creatorcontrib><creatorcontrib>Nomura, Takeo</creatorcontrib><creatorcontrib>Sakai, Yasunobu</creatorcontrib><creatorcontrib>Hirano, Masami</creatorcontrib><creatorcontrib>Yokomaku, Shozo</creatorcontrib><creatorcontrib>Nakayama, Shiro</creatorcontrib><creatorcontrib>Yoshida, Yutaka</creatorcontrib><creatorcontrib>Miura, Akira B</creatorcontrib><creatorcontrib>Morishima, Yasuo</creatorcontrib><creatorcontrib>Dohy, Hiroo</creatorcontrib><creatorcontrib>Niho, Yoshiyuki</creatorcontrib><creatorcontrib>Hamajima, Nobuyuki</creatorcontrib><creatorcontrib>Takaku, Fumimaro</creatorcontrib><title>Effect of Granulocyte Colony-Stimulating Factor after Intensive Induction Therapy in Relapsed or Refractory Acute Leukemia</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>THROUGH recent progress in chemotherapy and bone marrow transplantation, acute leukemia has become a curable disease. It has become clear, however, that intensive therapy is required to effect a cure, especially in acute myelogenous leukemia.
1
2
3
Myelosuppression from therapy and the infections that result have been the major obstacles in the treatment of acute leukemia.
Recently, colony-stimulating factors have been molecularly cloned and produced in sufficient quantities to allow their use in clinical trials.
4
Recombinant human granulocyte colony-stimulating factor (CSF) and granulocytemacrophage CSF are two of the factors that have been shown to increase the production of neutrophils in healthy volunteers . . .</description><subject>Acute Disease</subject><subject>Acute myeloid leukemia</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Blast crisis</subject><subject>Bone marrow</subject><subject>Bone Marrow - pathology</subject><subject>Bone marrow transplantation</subject><subject>Chemotherapy</subject><subject>Chronic myeloid leukemia</subject><subject>Colonies</subject><subject>Colonies & territories</subject><subject>Colony-stimulating factor</subject><subject>Colony-Stimulating Factors - adverse effects</subject><subject>Colony-Stimulating Factors - therapeutic use</subject><subject>Drug dosages</subject><subject>Female</subject><subject>Granulocyte Colony-Stimulating Factor</subject><subject>Granulocytes</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Induction therapy</subject><subject>Infection Control</subject><subject>Leukemia</subject><subject>Leukemia - complications</subject><subject>Leukemia - therapy</subject><subject>Leukocyte Count</subject><subject>Leukocytes (granulocytic)</subject><subject>Leukocytes (neutrophilic)</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myelodysplastic syndrome</subject><subject>Myeloid leukemia</subject><subject>Neutropenia</subject><subject>Neutropenia - therapy</subject><subject>Neutrophils</subject><subject>Preventive medicine</subject><subject>Prospective Studies</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Recombinant Proteins - adverse effects</subject><subject>Recombinant Proteins - therapeutic use</subject><subject>Recurrence</subject><subject>Remission</subject><subject>Remission Induction</subject><subject>Statistical analysis</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkVuLFDEQhYMo67j6C0QICr5Ia-XayeMyzK4ro8K6PjeZ7or22J2MSVpof729zoIgXuqlCuo7pygOIY8ZvGSg9Kt3mzdvmbUAlteCCyZA3iErpoSopAR9l6wAuKlkbcV98iDnPSzFpD0hJ0zbWku9It833mNbaPT0IrkwDbGdC9J1HGKYqw-lH6fBlT58oueuLTFR5wsmehkKhtx_w2Xqprb0MdDrz5jcYaZ9oFc4uEPGji6CK_Tpp3SmZ-20eG9x-oJj7x6Se94NGR_d9lPy8XxzvX5dbd9fXK7PtlWrQJWqU1JJaUB3xqsdF9JzC0oaKa1qO6U9SOMFcABpEZzdWcfQKWU70ymUTJyS50ffQ4pfJ8ylGfvc4jC4gHHKTW1tbbUU_wWZqo0VoBbw6W_gPk4pLE80nAurtDF6gZ79DWLWCMklFzc3xZFqU8w5oW8OqR9dmhsGzU3KzR9SXlRPbr2n3YjdL80x1mX_4rgfx9wE3I__dPsBd3itEQ</recordid><startdate>19900927</startdate><enddate>19900927</enddate><creator>Ohno, Ryuzo</creator><creator>Tomonaga, Masao</creator><creator>Kobayashi, Tohru</creator><creator>Kanamaru, Akihisa</creator><creator>Shirakawa, Shigeru</creator><creator>Masaoka, Tohru</creator><creator>Omine, Mitsuhiro</creator><creator>Oh, Hakumei</creator><creator>Nomura, Takeo</creator><creator>Sakai, Yasunobu</creator><creator>Hirano, Masami</creator><creator>Yokomaku, Shozo</creator><creator>Nakayama, Shiro</creator><creator>Yoshida, Yutaka</creator><creator>Miura, Akira B</creator><creator>Morishima, Yasuo</creator><creator>Dohy, Hiroo</creator><creator>Niho, Yoshiyuki</creator><creator>Hamajima, Nobuyuki</creator><creator>Takaku, Fumimaro</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19900927</creationdate><title>Effect of Granulocyte Colony-Stimulating Factor after Intensive Induction Therapy in Relapsed or Refractory Acute Leukemia</title><author>Ohno, Ryuzo ; Tomonaga, Masao ; Kobayashi, Tohru ; Kanamaru, Akihisa ; Shirakawa, Shigeru ; Masaoka, Tohru ; Omine, Mitsuhiro ; Oh, Hakumei ; Nomura, Takeo ; Sakai, Yasunobu ; Hirano, Masami ; Yokomaku, Shozo ; Nakayama, Shiro ; Yoshida, Yutaka ; Miura, Akira B ; Morishima, Yasuo ; Dohy, Hiroo ; Niho, Yoshiyuki ; Hamajima, Nobuyuki ; Takaku, Fumimaro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-d54544806d8f5b234f2905484495cd56f048f3020049e0a9b9a1ea559d8d5e413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Acute Disease</topic><topic>Acute myeloid leukemia</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Blast crisis</topic><topic>Bone marrow</topic><topic>Bone Marrow - pathology</topic><topic>Bone marrow transplantation</topic><topic>Chemotherapy</topic><topic>Chronic myeloid leukemia</topic><topic>Colonies</topic><topic>Colonies & territories</topic><topic>Colony-stimulating factor</topic><topic>Colony-Stimulating Factors - adverse effects</topic><topic>Colony-Stimulating Factors - therapeutic use</topic><topic>Drug dosages</topic><topic>Female</topic><topic>Granulocyte Colony-Stimulating Factor</topic><topic>Granulocytes</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Induction therapy</topic><topic>Infection Control</topic><topic>Leukemia</topic><topic>Leukemia - complications</topic><topic>Leukemia - therapy</topic><topic>Leukocyte Count</topic><topic>Leukocytes (granulocytic)</topic><topic>Leukocytes (neutrophilic)</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myelodysplastic syndrome</topic><topic>Myeloid leukemia</topic><topic>Neutropenia</topic><topic>Neutropenia - therapy</topic><topic>Neutrophils</topic><topic>Preventive medicine</topic><topic>Prospective Studies</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Recombinant Proteins - adverse effects</topic><topic>Recombinant Proteins - therapeutic use</topic><topic>Recurrence</topic><topic>Remission</topic><topic>Remission Induction</topic><topic>Statistical analysis</topic><topic>Transplantation</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohno, Ryuzo</creatorcontrib><creatorcontrib>Tomonaga, Masao</creatorcontrib><creatorcontrib>Kobayashi, Tohru</creatorcontrib><creatorcontrib>Kanamaru, Akihisa</creatorcontrib><creatorcontrib>Shirakawa, Shigeru</creatorcontrib><creatorcontrib>Masaoka, Tohru</creatorcontrib><creatorcontrib>Omine, Mitsuhiro</creatorcontrib><creatorcontrib>Oh, Hakumei</creatorcontrib><creatorcontrib>Nomura, Takeo</creatorcontrib><creatorcontrib>Sakai, Yasunobu</creatorcontrib><creatorcontrib>Hirano, Masami</creatorcontrib><creatorcontrib>Yokomaku, Shozo</creatorcontrib><creatorcontrib>Nakayama, Shiro</creatorcontrib><creatorcontrib>Yoshida, Yutaka</creatorcontrib><creatorcontrib>Miura, Akira B</creatorcontrib><creatorcontrib>Morishima, Yasuo</creatorcontrib><creatorcontrib>Dohy, Hiroo</creatorcontrib><creatorcontrib>Niho, Yoshiyuki</creatorcontrib><creatorcontrib>Hamajima, Nobuyuki</creatorcontrib><creatorcontrib>Takaku, Fumimaro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohno, Ryuzo</au><au>Tomonaga, Masao</au><au>Kobayashi, Tohru</au><au>Kanamaru, Akihisa</au><au>Shirakawa, Shigeru</au><au>Masaoka, Tohru</au><au>Omine, Mitsuhiro</au><au>Oh, Hakumei</au><au>Nomura, Takeo</au><au>Sakai, Yasunobu</au><au>Hirano, Masami</au><au>Yokomaku, Shozo</au><au>Nakayama, Shiro</au><au>Yoshida, Yutaka</au><au>Miura, Akira B</au><au>Morishima, Yasuo</au><au>Dohy, Hiroo</au><au>Niho, Yoshiyuki</au><au>Hamajima, Nobuyuki</au><au>Takaku, Fumimaro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Granulocyte Colony-Stimulating Factor after Intensive Induction Therapy in Relapsed or Refractory Acute Leukemia</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1990-09-27</date><risdate>1990</risdate><volume>323</volume><issue>13</issue><spage>871</spage><epage>877</epage><pages>871-877</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>THROUGH recent progress in chemotherapy and bone marrow transplantation, acute leukemia has become a curable disease. It has become clear, however, that intensive therapy is required to effect a cure, especially in acute myelogenous leukemia.
1
2
3
Myelosuppression from therapy and the infections that result have been the major obstacles in the treatment of acute leukemia.
Recently, colony-stimulating factors have been molecularly cloned and produced in sufficient quantities to allow their use in clinical trials.
4
Recombinant human granulocyte colony-stimulating factor (CSF) and granulocytemacrophage CSF are two of the factors that have been shown to increase the production of neutrophils in healthy volunteers . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>1697646</pmid><doi>10.1056/NEJM199009273231304</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1990-09, Vol.323 (13), p.871-877 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Acute Disease Acute myeloid leukemia Adolescent Adult Aged Blast crisis Bone marrow Bone Marrow - pathology Bone marrow transplantation Chemotherapy Chronic myeloid leukemia Colonies Colonies & territories Colony-stimulating factor Colony-Stimulating Factors - adverse effects Colony-Stimulating Factors - therapeutic use Drug dosages Female Granulocyte Colony-Stimulating Factor Granulocytes Hospitals Humans Induction therapy Infection Control Leukemia Leukemia - complications Leukemia - therapy Leukocyte Count Leukocytes (granulocytic) Leukocytes (neutrophilic) Male Middle Aged Myelodysplastic syndrome Myeloid leukemia Neutropenia Neutropenia - therapy Neutrophils Preventive medicine Prospective Studies Randomized Controlled Trials as Topic Recombinant Proteins - adverse effects Recombinant Proteins - therapeutic use Recurrence Remission Remission Induction Statistical analysis Transplantation Transplants & implants |
| title | Effect of Granulocyte Colony-Stimulating Factor after Intensive Induction Therapy in Relapsed or Refractory Acute Leukemia |
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