Facile, solvent and ligand free iron catalyzed direct functionalization of N-protected tetrahydroisoquinolines and isochroman

An efficient method for an iron catalyzed oxidative indolation and methoxyphenylation of N-protected tetrahydroisoquinolines and isochroman is described including subsequent facile deprotection.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2010-12, Vol.46 (46), p.8836-8838
Hauptverfasser:	Ghobrial, Michael, Harhammer, Karin, Mihovilovic, Marko D, Schnürch, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Chromans - chemical synthesis Chromans - chemistry Iron - chemistry Ligands Molecular Structure Solvents - chemistry Stereoisomerism Tetrahydroisoquinolines - chemical synthesis Tetrahydroisoquinolines - chemistry
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Beschreibung
Zusammenfassung:	An efficient method for an iron catalyzed oxidative indolation and methoxyphenylation of N-protected tetrahydroisoquinolines and isochroman is described including subsequent facile deprotection.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c0cc02491k