The effect on human sex ratio at birth by assisted reproductive technology (ART) procedures – an assessment of babies born following single embryo transfers, Australia and New Zealand, 2002–2006
Please cite this paper as: Dean J, Chapman M, Sullivan E. The effect on human sex ratio at birth by assisted reproductive technology (ART) procedures – an assessment of babies born following single embryo transfers, Australia and New Zealand, 2002–2006. BJOG 2010;117:1628–1634. Objective To assess...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 2010-12, Vol.117 (13), p.1628-1634 |
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| container_title | BJOG : an international journal of obstetrics and gynaecology |
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| creator | Dean, JH Chapman, MG Sullivan, EA |
| description | Please cite this paper as: Dean J, Chapman M, Sullivan E. The effect on human sex ratio at birth by assisted reproductive technology (ART) procedures – an assessment of babies born following single embryo transfers, Australia and New Zealand, 2002–2006. BJOG 2010;117:1628–1634.
Objective To assess the effect on the human sex ratio at birth by assisted reproductive technology (ART) procedures.
Design Retrospective population‐based study.
Setting Fertility clinics in Australia and New Zealand.
Population The study included 13 368 babies by 13 165 women who had a single embryo transfer (SET) between 2002 and 2006.
Methods Logistic regression was used to model the effect on the sex ratio at birth of ART characteristics [in vitro fertilisation (IVF) or intracytoplasmic sperm insemination (ICSI) SET, cleavage‐stage or blastocyst SET, and fresh or thawed SET] and biological characteristics (woman’s and partner’s age and cause of infertility).
Main outcome measures Proportion of male births.
Results The crude sex ratio at birth was 51.3%. Individual ART procedures had a significant effect on the sex ratio at birth. More males were born following IVF SET (53.0%) than ICSI SET (50.0%), and following blastocyst SET (54.1%) than cleavage‐stage SET (49.9%). For a specific ART regimen, IVF blastocyst SET produced more males (56.1%) and ICSI cleavage‐stage SET produced fewer males (48.7%).
Conclusions The change in the sex ratio at birth of SET babies is associated with the ART regimen. The mechanism of these effects remains unclear. Fertility clinics and patients should be aware of the bias in the sex ratio at birth when using ART procedures. |
| doi_str_mv | 10.1111/j.1471-0528.2010.02731.x |
| format | Article |
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Objective To assess the effect on the human sex ratio at birth by assisted reproductive technology (ART) procedures.
Design Retrospective population‐based study.
Setting Fertility clinics in Australia and New Zealand.
Population The study included 13 368 babies by 13 165 women who had a single embryo transfer (SET) between 2002 and 2006.
Methods Logistic regression was used to model the effect on the sex ratio at birth of ART characteristics [in vitro fertilisation (IVF) or intracytoplasmic sperm insemination (ICSI) SET, cleavage‐stage or blastocyst SET, and fresh or thawed SET] and biological characteristics (woman’s and partner’s age and cause of infertility).
Main outcome measures Proportion of male births.
Results The crude sex ratio at birth was 51.3%. Individual ART procedures had a significant effect on the sex ratio at birth. More males were born following IVF SET (53.0%) than ICSI SET (50.0%), and following blastocyst SET (54.1%) than cleavage‐stage SET (49.9%). For a specific ART regimen, IVF blastocyst SET produced more males (56.1%) and ICSI cleavage‐stage SET produced fewer males (48.7%).
Conclusions The change in the sex ratio at birth of SET babies is associated with the ART regimen. The mechanism of these effects remains unclear. Fertility clinics and patients should be aware of the bias in the sex ratio at birth when using ART procedures.</description><identifier>ISSN: 1470-0328</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/j.1471-0528.2010.02731.x</identifier><identifier>PMID: 20875033</identifier><identifier>CODEN: BIOGFQ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; ART births ; Australia - epidemiology ; Biological and medical sciences ; Birth control ; Births ; blastocyst ; cleavage‐stage embryo ; Embryo Transfer - methods ; Embryo Transfer - statistics & numerical data ; Embryos ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; ICSI ; Infant, Newborn ; Infertility, Female - epidemiology ; Infertility, Female - therapy ; Infertility, Male - epidemiology ; Infertility, Male - therapy ; IVF ; logistic regression ; Male ; Medical procedures ; Medical sciences ; New Zealand - epidemiology ; Reproductive technologies ; Retrospective Studies ; Sex Ratio ; sex ratio at birth ; single embryo transfer ; Sterility. Assisted procreation</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 2010-12, Vol.117 (13), p.1628-1634</ispartof><rights>2010 The Authors Journal compilation © RCOG 2010 BJOG An International Journal of Obstetrics and Gynaecology</rights><rights>2015 INIST-CNRS</rights><rights>2010 The Authors Journal compilation © RCOG 2010 BJOG An International Journal of Obstetrics and Gynaecology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4751-df1096932d0af1ae12b36e8230d1ab8ab903a116b8469d20e3a78bf8c5a935f43</citedby><cites>FETCH-LOGICAL-c4751-df1096932d0af1ae12b36e8230d1ab8ab903a116b8469d20e3a78bf8c5a935f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-0528.2010.02731.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-0528.2010.02731.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23419833$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20875033$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dean, JH</creatorcontrib><creatorcontrib>Chapman, MG</creatorcontrib><creatorcontrib>Sullivan, EA</creatorcontrib><title>The effect on human sex ratio at birth by assisted reproductive technology (ART) procedures – an assessment of babies born following single embryo transfers, Australia and New Zealand, 2002–2006</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>BJOG</addtitle><description>Please cite this paper as: Dean J, Chapman M, Sullivan E. The effect on human sex ratio at birth by assisted reproductive technology (ART) procedures – an assessment of babies born following single embryo transfers, Australia and New Zealand, 2002–2006. BJOG 2010;117:1628–1634.
Objective To assess the effect on the human sex ratio at birth by assisted reproductive technology (ART) procedures.
Design Retrospective population‐based study.
Setting Fertility clinics in Australia and New Zealand.
Population The study included 13 368 babies by 13 165 women who had a single embryo transfer (SET) between 2002 and 2006.
Methods Logistic regression was used to model the effect on the sex ratio at birth of ART characteristics [in vitro fertilisation (IVF) or intracytoplasmic sperm insemination (ICSI) SET, cleavage‐stage or blastocyst SET, and fresh or thawed SET] and biological characteristics (woman’s and partner’s age and cause of infertility).
Main outcome measures Proportion of male births.
Results The crude sex ratio at birth was 51.3%. Individual ART procedures had a significant effect on the sex ratio at birth. More males were born following IVF SET (53.0%) than ICSI SET (50.0%), and following blastocyst SET (54.1%) than cleavage‐stage SET (49.9%). For a specific ART regimen, IVF blastocyst SET produced more males (56.1%) and ICSI cleavage‐stage SET produced fewer males (48.7%).
Conclusions The change in the sex ratio at birth of SET babies is associated with the ART regimen. The mechanism of these effects remains unclear. Fertility clinics and patients should be aware of the bias in the sex ratio at birth when using ART procedures.</description><subject>Adult</subject><subject>ART births</subject><subject>Australia - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Births</subject><subject>blastocyst</subject><subject>cleavage‐stage embryo</subject><subject>Embryo Transfer - methods</subject><subject>Embryo Transfer - statistics & numerical data</subject><subject>Embryos</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>ICSI</subject><subject>Infant, Newborn</subject><subject>Infertility, Female - epidemiology</subject><subject>Infertility, Female - therapy</subject><subject>Infertility, Male - epidemiology</subject><subject>Infertility, Male - therapy</subject><subject>IVF</subject><subject>logistic regression</subject><subject>Male</subject><subject>Medical procedures</subject><subject>Medical sciences</subject><subject>New Zealand - epidemiology</subject><subject>Reproductive technologies</subject><subject>Retrospective Studies</subject><subject>Sex Ratio</subject><subject>sex ratio at birth</subject><subject>single embryo transfer</subject><subject>Sterility. Assisted procreation</subject><issn>1470-0328</issn><issn>1471-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAQxyMEoqXwCmiEhACpu_gjmzgHDkvFpyoqoXLhYtnJuOtVErd2wu7eeAfeiQfhSZj9oEic8MEz9vzmw_5nGXA25bReLqc8L_mEzYSaCka3TJSST9d3suPbwN2dzyZMCnWUPUhpyRgvBJP3syPBVDljUh5nPy8XCOgc1gOEHhZjZ3pIuIZoBh_ADGB9HBZgN2BS8mnABiJex9CM9eC_IQxYL_rQhqsNPJ9_vnwBFKuxGSMm-PX9B1A5SsSUOuyphQNrrKeYDbEHF9o2rHx_BYm2libpbNwEGKLpk8OYTmE-Jjq13lClBj7hCr6iack_BcGYoBZkiofZPWfahI8O9iT78vbN5dn7yfnFuw9n8_NJnZczPmkcZ1VRSdEw47hBLqwsUAnJGm6sMrZi0nBeWJUXVSMYSlMq61Q9M5WcuVyeZM_2demVNyOmQXc-1djSQBjGpMuqKitRFpzIJ_-QyzDGnobTZZkrpQQTBKk9VMeQUkSnr6PvTNxozvRWab3UW0H1VlC9VVrvlNZrSn18qD_aDpvbxD_SEvD0AJhUm9bRl9Y-_eVkziu1417tuZVvcfPfA-jXHy-2nvwNrxjGig</recordid><startdate>201012</startdate><enddate>201012</enddate><creator>Dean, JH</creator><creator>Chapman, MG</creator><creator>Sullivan, EA</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201012</creationdate><title>The effect on human sex ratio at birth by assisted reproductive technology (ART) procedures – an assessment of babies born following single embryo transfers, Australia and New Zealand, 2002–2006</title><author>Dean, JH ; Chapman, MG ; Sullivan, EA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4751-df1096932d0af1ae12b36e8230d1ab8ab903a116b8469d20e3a78bf8c5a935f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>ART births</topic><topic>Australia - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Births</topic><topic>blastocyst</topic><topic>cleavage‐stage embryo</topic><topic>Embryo Transfer - methods</topic><topic>Embryo Transfer - statistics & numerical data</topic><topic>Embryos</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>ICSI</topic><topic>Infant, Newborn</topic><topic>Infertility, Female - epidemiology</topic><topic>Infertility, Female - therapy</topic><topic>Infertility, Male - epidemiology</topic><topic>Infertility, Male - therapy</topic><topic>IVF</topic><topic>logistic regression</topic><topic>Male</topic><topic>Medical procedures</topic><topic>Medical sciences</topic><topic>New Zealand - epidemiology</topic><topic>Reproductive technologies</topic><topic>Retrospective Studies</topic><topic>Sex Ratio</topic><topic>sex ratio at birth</topic><topic>single embryo transfer</topic><topic>Sterility. Assisted procreation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dean, JH</creatorcontrib><creatorcontrib>Chapman, MG</creatorcontrib><creatorcontrib>Sullivan, EA</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dean, JH</au><au>Chapman, MG</au><au>Sullivan, EA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect on human sex ratio at birth by assisted reproductive technology (ART) procedures – an assessment of babies born following single embryo transfers, Australia and New Zealand, 2002–2006</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>BJOG</addtitle><date>2010-12</date><risdate>2010</risdate><volume>117</volume><issue>13</issue><spage>1628</spage><epage>1634</epage><pages>1628-1634</pages><issn>1470-0328</issn><eissn>1471-0528</eissn><coden>BIOGFQ</coden><abstract>Please cite this paper as: Dean J, Chapman M, Sullivan E. The effect on human sex ratio at birth by assisted reproductive technology (ART) procedures – an assessment of babies born following single embryo transfers, Australia and New Zealand, 2002–2006. BJOG 2010;117:1628–1634.
Objective To assess the effect on the human sex ratio at birth by assisted reproductive technology (ART) procedures.
Design Retrospective population‐based study.
Setting Fertility clinics in Australia and New Zealand.
Population The study included 13 368 babies by 13 165 women who had a single embryo transfer (SET) between 2002 and 2006.
Methods Logistic regression was used to model the effect on the sex ratio at birth of ART characteristics [in vitro fertilisation (IVF) or intracytoplasmic sperm insemination (ICSI) SET, cleavage‐stage or blastocyst SET, and fresh or thawed SET] and biological characteristics (woman’s and partner’s age and cause of infertility).
Main outcome measures Proportion of male births.
Results The crude sex ratio at birth was 51.3%. Individual ART procedures had a significant effect on the sex ratio at birth. More males were born following IVF SET (53.0%) than ICSI SET (50.0%), and following blastocyst SET (54.1%) than cleavage‐stage SET (49.9%). For a specific ART regimen, IVF blastocyst SET produced more males (56.1%) and ICSI cleavage‐stage SET produced fewer males (48.7%).
Conclusions The change in the sex ratio at birth of SET babies is associated with the ART regimen. The mechanism of these effects remains unclear. Fertility clinics and patients should be aware of the bias in the sex ratio at birth when using ART procedures.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20875033</pmid><doi>10.1111/j.1471-0528.2010.02731.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult ART births Australia - epidemiology Biological and medical sciences Birth control Births blastocyst cleavage‐stage embryo Embryo Transfer - methods Embryo Transfer - statistics & numerical data Embryos Female Gynecology. Andrology. Obstetrics Humans ICSI Infant, Newborn Infertility, Female - epidemiology Infertility, Female - therapy Infertility, Male - epidemiology Infertility, Male - therapy IVF logistic regression Male Medical procedures Medical sciences New Zealand - epidemiology Reproductive technologies Retrospective Studies Sex Ratio sex ratio at birth single embryo transfer Sterility. Assisted procreation |
| title | The effect on human sex ratio at birth by assisted reproductive technology (ART) procedures – an assessment of babies born following single embryo transfers, Australia and New Zealand, 2002–2006 |
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