Ovarian stimulation using human menopausal gonadotrophins with or without LHRH analogues in a long protocol for in-vitro fertilization: a prospective randomized comparison
In order to evaluate the exact role of GnRH agonists, we have undertaken a randomized prospective study comparing two groups of 90 normo-ovulatory patients, aged
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| Veröffentlicht in: | Human reproduction (Oxford) 1990-07, Vol.5 (5), p.565-569 |
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| container_title | Human reproduction (Oxford) |
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| creator | Antoine, J.M. Salat-Baroux, J. Alvarez, S. Cornet, D. Tibi, Ch Mandelbaum, J. Plachot, M. |
| description | In order to evaluate the exact role of GnRH agonists, we have undertaken a randomized prospective study comparing two groups of 90 normo-ovulatory patients, aged |
| doi_str_mv | 10.1093/oxfordjournals.humrep.a137144 |
| format | Article |
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Apart from the well known results demonstrated in the literature of a reduced incidence of inadequate responses, an absence of premature luteinization and a greater number of oocytes per retrieval (8.8 ± 4.9 versus 6.8 ± 3.2, P < 0.01 in group II), this study confirms the higher pregnancy rate (21.1 versus 12.2% per cycle and 24.7 versus 17.1% per oocyte retrieval, not significant) and underlines the higher plasma progesterone levels and lower E2/P ratio in group I from D − 1 to D + 5, which could explain a better maturation of the oocytes and the endometrium.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/oxfordjournals.humrep.a137144</identifier><identifier>PMID: 2144296</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Clinical Trials as Topic ; Estradiol - blood ; Female ; Fertilization in Vitro ; Gonadotropin-Releasing Hormone - administration & dosage ; Gonadotropin-Releasing Hormone - analogs & derivatives ; Gonadotropin-Releasing Hormone - therapeutic use ; Humans ; in-vitro fertilization ; Infertility, Female - therapy ; LHRH agonists ; Luteinizing Hormone - blood ; Menotropins - administration & dosage ; Menotropins - therapeutic use ; Ovulation Induction ; Pregnancy ; Progesterone - blood ; Prospective Studies ; Random Allocation ; Triptorelin Pamoate</subject><ispartof>Human reproduction (Oxford), 1990-07, Vol.5 (5), p.565-569</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c273t-5f06f7588142ad32fa75bcdfb88cc4a8fe4c927686222bfcdf2d4c9de2e53b53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2144296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Antoine, J.M.</creatorcontrib><creatorcontrib>Salat-Baroux, J.</creatorcontrib><creatorcontrib>Alvarez, S.</creatorcontrib><creatorcontrib>Cornet, D.</creatorcontrib><creatorcontrib>Tibi, Ch</creatorcontrib><creatorcontrib>Mandelbaum, J.</creatorcontrib><creatorcontrib>Plachot, M.</creatorcontrib><title>Ovarian stimulation using human menopausal gonadotrophins with or without LHRH analogues in a long protocol for in-vitro fertilization: a prospective randomized comparison</title><title>Human reproduction (Oxford)</title><addtitle>Hum Reprod</addtitle><description>In order to evaluate the exact role of GnRH agonists, we have undertaken a randomized prospective study comparing two groups of 90 normo-ovulatory patients, aged <38 years and with tubal infertility with no male factor. Luteinizing hormone releasing hormone analogue (DTRP6 administered in a long protocol, for at least 15 days) was associated with human menopausal gonadotrophin (HMG) induction in group I. In group II, stimulation was performed using HMG alone (three ampoules per day in general, from days 2 to 7 of the cycle). Apart from the well known results demonstrated in the literature of a reduced incidence of inadequate responses, an absence of premature luteinization and a greater number of oocytes per retrieval (8.8 ± 4.9 versus 6.8 ± 3.2, P < 0.01 in group II), this study confirms the higher pregnancy rate (21.1 versus 12.2% per cycle and 24.7 versus 17.1% per oocyte retrieval, not significant) and underlines the higher plasma progesterone levels and lower E2/P ratio in group I from D − 1 to D + 5, which could explain a better maturation of the oocytes and the endometrium.</description><subject>Adult</subject><subject>Clinical Trials as Topic</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Gonadotropin-Releasing Hormone - administration & dosage</subject><subject>Gonadotropin-Releasing Hormone - analogs & derivatives</subject><subject>Gonadotropin-Releasing Hormone - therapeutic use</subject><subject>Humans</subject><subject>in-vitro fertilization</subject><subject>Infertility, Female - therapy</subject><subject>LHRH agonists</subject><subject>Luteinizing Hormone - blood</subject><subject>Menotropins - administration & dosage</subject><subject>Menotropins - therapeutic use</subject><subject>Ovulation Induction</subject><subject>Pregnancy</subject><subject>Progesterone - blood</subject><subject>Prospective Studies</subject><subject>Random Allocation</subject><subject>Triptorelin Pamoate</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUV2LFDEQDKKc6-lPEPKib7PmYyaZEXyQ43SFxQM5UHwJmUyym3MmGZPMet5f8k_a3i4HPnXTVV1dTSH0ipI1JR1_E29dTMNNXFLQY17vlynZea0pl7SuH6EVrQWpGG_IY7QiTLQVpYI-Rc9yviEE2lacoTMGXNaJFfpzddDJ64Bz8dMy6uJjwEv2YYdBGeaTDXHWS9Yj3sWgh1hSnPc-ZPzLlz2O6b7GpeDt5ssGazAVd4vN2Aes8RhBaE6xRBNHDMZhXB08aGBnU_Gjv7s_-Ra4QMuzNcUfLE46DHHyd3bAJk4zWMwxPEdPHLxsX5zqObr-cHl9sam2Vx8_XbzfVoZJXqrGEeFk07a0ZnrgzGnZ9GZwfdsaU-vW2dp0TIpWMMZ6BwgbYDJYZhveN_wcvT7KgqGf8ElRk8_GjqMONi5Zya6TkrQciO-ORAPOc7JOzclPOv1WlKh_Wan_s1LHrNQpK9h_eTq09JMdHrZP4QBeHXGfi719gHX6oYTkslGbb9_VZ97UX8WWKcL_AseCrjQ</recordid><startdate>199007</startdate><enddate>199007</enddate><creator>Antoine, J.M.</creator><creator>Salat-Baroux, J.</creator><creator>Alvarez, S.</creator><creator>Cornet, D.</creator><creator>Tibi, Ch</creator><creator>Mandelbaum, J.</creator><creator>Plachot, M.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199007</creationdate><title>Ovarian stimulation using human menopausal gonadotrophins with or without LHRH analogues in a long protocol for in-vitro fertilization: a prospective randomized comparison</title><author>Antoine, J.M. ; Salat-Baroux, J. ; Alvarez, S. ; Cornet, D. ; Tibi, Ch ; Mandelbaum, J. ; Plachot, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c273t-5f06f7588142ad32fa75bcdfb88cc4a8fe4c927686222bfcdf2d4c9de2e53b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Clinical Trials as Topic</topic><topic>Estradiol - blood</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Gonadotropin-Releasing Hormone - administration & dosage</topic><topic>Gonadotropin-Releasing Hormone - analogs & derivatives</topic><topic>Gonadotropin-Releasing Hormone - therapeutic use</topic><topic>Humans</topic><topic>in-vitro fertilization</topic><topic>Infertility, Female - therapy</topic><topic>LHRH agonists</topic><topic>Luteinizing Hormone - blood</topic><topic>Menotropins - administration & dosage</topic><topic>Menotropins - therapeutic use</topic><topic>Ovulation Induction</topic><topic>Pregnancy</topic><topic>Progesterone - blood</topic><topic>Prospective Studies</topic><topic>Random Allocation</topic><topic>Triptorelin Pamoate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Antoine, J.M.</creatorcontrib><creatorcontrib>Salat-Baroux, J.</creatorcontrib><creatorcontrib>Alvarez, S.</creatorcontrib><creatorcontrib>Cornet, D.</creatorcontrib><creatorcontrib>Tibi, Ch</creatorcontrib><creatorcontrib>Mandelbaum, J.</creatorcontrib><creatorcontrib>Plachot, M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Antoine, J.M.</au><au>Salat-Baroux, J.</au><au>Alvarez, S.</au><au>Cornet, D.</au><au>Tibi, Ch</au><au>Mandelbaum, J.</au><au>Plachot, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ovarian stimulation using human menopausal gonadotrophins with or without LHRH analogues in a long protocol for in-vitro fertilization: a prospective randomized comparison</atitle><jtitle>Human reproduction (Oxford)</jtitle><addtitle>Hum Reprod</addtitle><date>1990-07</date><risdate>1990</risdate><volume>5</volume><issue>5</issue><spage>565</spage><epage>569</epage><pages>565-569</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><abstract>In order to evaluate the exact role of GnRH agonists, we have undertaken a randomized prospective study comparing two groups of 90 normo-ovulatory patients, aged <38 years and with tubal infertility with no male factor. Luteinizing hormone releasing hormone analogue (DTRP6 administered in a long protocol, for at least 15 days) was associated with human menopausal gonadotrophin (HMG) induction in group I. In group II, stimulation was performed using HMG alone (three ampoules per day in general, from days 2 to 7 of the cycle). Apart from the well known results demonstrated in the literature of a reduced incidence of inadequate responses, an absence of premature luteinization and a greater number of oocytes per retrieval (8.8 ± 4.9 versus 6.8 ± 3.2, P < 0.01 in group II), this study confirms the higher pregnancy rate (21.1 versus 12.2% per cycle and 24.7 versus 17.1% per oocyte retrieval, not significant) and underlines the higher plasma progesterone levels and lower E2/P ratio in group I from D − 1 to D + 5, which could explain a better maturation of the oocytes and the endometrium.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>2144296</pmid><doi>10.1093/oxfordjournals.humrep.a137144</doi><tpages>5</tpages></addata></record> |
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| ispartof | Human reproduction (Oxford), 1990-07, Vol.5 (5), p.565-569 |
| issn | 0268-1161 1460-2350 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Adult Clinical Trials as Topic Estradiol - blood Female Fertilization in Vitro Gonadotropin-Releasing Hormone - administration & dosage Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - therapeutic use Humans in-vitro fertilization Infertility, Female - therapy LHRH agonists Luteinizing Hormone - blood Menotropins - administration & dosage Menotropins - therapeutic use Ovulation Induction Pregnancy Progesterone - blood Prospective Studies Random Allocation Triptorelin Pamoate |
| title | Ovarian stimulation using human menopausal gonadotrophins with or without LHRH analogues in a long protocol for in-vitro fertilization: a prospective randomized comparison |
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