Prospective New Developments in Laboratory Research and Clinical Trials in Prostatic Cancer
Laboratory research continues to develop new methods supporting clinicians in the management of prostatic cancer. Routine measurements of serum prostate‐specific antigen (PSA) levels improve diagnosis, provide insight into tumor burden, and sharpen prognostication. New organ‐specific antigenic targe...
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| Veröffentlicht in: | Cancer 1990-09, Vol.66 (5), p.1083-1085 |
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| container_issue | 5 |
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| container_title | Cancer |
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| creator | Horoszewicz, Julius S. Murphy, Gerald P. |
| description | Laboratory research continues to develop new methods supporting clinicians in the management of prostatic cancer. Routine measurements of serum prostate‐specific antigen (PSA) levels improve diagnosis, provide insight into tumor burden, and sharpen prognostication. New organ‐specific antigenic targets are identified for monoclonal antibody‐directed diagnostic and radiotherapeutic reagents. Such new immunospecific conjugates are already under evaluation in clinical trials. Cell culture techniques carry the promise of noninvasive early detection and prognostic evaluation of prostatic malignancy in preclinical stages. Molecular mechanisms responsible for androgen regulation of proliferation and malignancy of prostatic cancer are becoming open for scientific inquiry. |
| doi_str_mv | 10.1002/cncr.1990.66.s5.1083 |
| format | Article |
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Molecular mechanisms responsible for androgen regulation of proliferation and malignancy of prostatic cancer are becoming open for scientific inquiry.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.1990.66.s5.1083</identifier><identifier>PMID: 2203519</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York, NY: Wiley-Liss</publisher><subject>Animals ; Antineoplastic agents ; Biological and medical sciences ; Clinical Trials as Topic ; General aspects ; Humans ; Male ; Medical sciences ; Mice ; Mice, Nude ; Pharmacology. 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Routine measurements of serum prostate‐specific antigen (PSA) levels improve diagnosis, provide insight into tumor burden, and sharpen prognostication. New organ‐specific antigenic targets are identified for monoclonal antibody‐directed diagnostic and radiotherapeutic reagents. Such new immunospecific conjugates are already under evaluation in clinical trials. Cell culture techniques carry the promise of noninvasive early detection and prognostic evaluation of prostatic malignancy in preclinical stages. Molecular mechanisms responsible for androgen regulation of proliferation and malignancy of prostatic cancer are becoming open for scientific inquiry.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Clinical Trials as Topic</subject><subject>General aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Pharmacology. Drug treatments</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Prostatic Neoplasms - therapy</subject><subject>Tumor Cells, Cultured</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9P3DAQxS1URBfKN6CSL-WWxX9iOz62oaWVVlBRkJA4WI4zEUbZJNjZRfvt6-yu4MrJ8rw3b2Z-CJ1RMqeEsAvXuTCnWpO5lPMoUrHgB2hGiVYZoTn7hGaEkCITOX_4jI5jfE5fxQQ_QkeMES6onqHHv6GPA7jRrwFfwyu-hDW0_bCEbozYd3hhqz7YsQ8bfAsRbHBP2HY1LlvfeWdbfBe8bbfWKWq0o3e4tJ2D8AUdNkmC0_17gu5__bwrf2eLm6s_5fdF5nKueOaoTesIIrSTVOcSLJesqS0IxptGplttXlSKKFnLhpOC1UpWuVKqqFxRkIafoPNd7hD6lxXE0Sx9dNC2toN-FY3SWklOeDLmO6NLm8YAjRmCX9qwMZSYiamZmJqJqZHSRGEmpqnt6z5_VS2hfmvaQ0z6t71uYyLShHS9j-_ZWuaCSZV8P3a-V9_C5kOzTXld3k41Kf-J7TL_AcUelAI</recordid><startdate>199009</startdate><enddate>199009</enddate><creator>Horoszewicz, Julius S.</creator><creator>Murphy, Gerald P.</creator><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199009</creationdate><title>Prospective New Developments in Laboratory Research and Clinical Trials in Prostatic Cancer</title><author>Horoszewicz, Julius S. ; Murphy, Gerald P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4373-c1a2205059c61946ea362fdae523ff6100a48b7076d6f3082d76b47778bc880f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Clinical Trials as Topic</topic><topic>General aspects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Pharmacology. Drug treatments</topic><topic>Prostatic Neoplasms - diagnosis</topic><topic>Prostatic Neoplasms - therapy</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horoszewicz, Julius S.</creatorcontrib><creatorcontrib>Murphy, Gerald P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horoszewicz, Julius S.</au><au>Murphy, Gerald P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective New Developments in Laboratory Research and Clinical Trials in Prostatic Cancer</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1990-09</date><risdate>1990</risdate><volume>66</volume><issue>5</issue><spage>1083</spage><epage>1085</epage><pages>1083-1085</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>Laboratory research continues to develop new methods supporting clinicians in the management of prostatic cancer. 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| fulltext | fulltext |
| identifier | ISSN: 0008-543X |
| ispartof | Cancer, 1990-09, Vol.66 (5), p.1083-1085 |
| issn | 0008-543X 1097-0142 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79976303 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Antineoplastic agents Biological and medical sciences Clinical Trials as Topic General aspects Humans Male Medical sciences Mice Mice, Nude Pharmacology. Drug treatments Prostatic Neoplasms - diagnosis Prostatic Neoplasms - therapy Tumor Cells, Cultured |
| title | Prospective New Developments in Laboratory Research and Clinical Trials in Prostatic Cancer |
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