Synthesis and Biological Evaluation of Quinocarcin Derivatives

Cyanation of quinocarcin readily opened the oxazolidine ring to provide DX-52-1 (2), which was a key compound in the synthesis of quinocarcin derivatives. Various electrophilic reactions toward aromatic ring of DX-52-1 were examined, and 10-substituted (e.g., halogen, nitro, formyl, cyano, hydroxy,...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1990/05/25, Vol.38(5), pp.1278-1285
Hauptverfasser:	SAITO, Hiromitsu, KOBAYASHI, Shigeru, UOSAKI, Youichi, SATO, Akira, FUJIMOTO, Kazuhisa, MIYOSHI, Katunori, ASHIZAWA, Tadashi, MORIMOTO, Makoto, HIRATA, Tadashi
Format:	Artikel
Sprache:	eng
Schlagworte:	10-halo quinocarcin derivative 10-substituted DX-52-1 analog Animals Antibiotics, Antineoplastic - chemical synthesis antitumor activity Chemical Phenomena Chemistry cyanation DX-52-1 electrophilic substitution Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Isoquinolines - chemical synthesis Isoquinolines - pharmacology Leukemia P388 - drug therapy Mice Mice, Inbred BALB C Mice, Inbred Strains Organic chemistry Preparations and properties quinocarcin
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