Suramin inhibits laminin- and thrombospondin-mediated melanoma cell adhesion and migration and binding of these adhesive proteins to sulfatide

Suramin is a polysulfonated drug with several biological activities including inhibition of binding of some growth factors to cells, inhibition of tumor cell growth, and of glycosaminoglycan metabolism. We report here that suramin also inhibits binding of the adhesive glycoproteins, thrombospondin a...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1990-09, Vol.50 (18), p.5937-5942
Hauptverfasser:	ZABRENETZKY, V. S, KOHN, E. C, ROBERTS, D. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Binding Sites Biological and medical sciences Cell Adhesion - drug effects Cell Movement - drug effects Chemotherapy Heparin - metabolism Humans laminin Laminin - antagonists & inhibitors Laminin - metabolism Laminin - pharmacology Medical sciences Melanoma - metabolism Melanoma - pathology Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - metabolism Membrane Glycoproteins - pharmacology Pharmacology. Drug treatments Protein Binding Sulfoglycosphingolipids - metabolism suramin Suramin - pharmacology thrombospondin Thrombospondins Tumor Cells, Cultured
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