U73122 and U73343 inhibit receptor-mediated phospholipase D activation downstream of phospholipase C in CHO cells

The aminosteroid 1-(6-{[17 β-3-methoxyestra-1,3,5(10)-trien-17-yl]-amino}hexyl)-1 H-pyrrole-2,5-dione (U73122) and its inactive analogue 1-(6-{[17 β-3-methoxyestra-1,3,5(10)-trien-17-yl]-amino}hexyl-2,5-pyrrolidine-dione (U73343) are widely used to study the involvement of G protein-coupled 1-phosph...

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Veröffentlicht in:	European journal of pharmacology 1998-04, Vol.346 (2), p.345-351
Hauptverfasser:	Bosch, Remko R, Patel, Anjana M.P, Van Emst-de Vries, Sjenet E, Smeets, Rolf L.L, De Pont, Jan Joep H.H.M, Willems, Peter H.G.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences CCK A receptor Cell receptors Cell structures and functions CHO Cells Cricetinae Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Estrenes - pharmacology Fundamental and applied biological sciences. Psychology Miscellaneous Molecular and cellular biology Phospholipase C Phospholipase D Phospholipase D - antagonists & inhibitors Phospholipase D - metabolism Phospholipids - biosynthesis Phospholipids - isolation & purification Protein kinase C Pyrrolidinones - pharmacology Receptors, Cholecystokinin - antagonists & inhibitors Receptors, Cholecystokinin - metabolism Spectrometry, Fluorescence Type C Phospholipases - antagonists & inhibitors Type C Phospholipases - metabolism U73122 U73343
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