Adoptive immunotherapy of human cancer: the cytokine cascade and monocyte activation following high-dose interleukin 2 bolus treatment
Serum concentration kinetics of gamma-interferon (IFN-gamma), neopterin, 2'-5' A synthetase and tumor necrosis factor alpha were determined in five cancer patients undergoing adoptive immunotherapy with high-dose interleukin 2 (IL-2) bolus infusion and lymphokine-activated killer cells acc...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1990-09, Vol.50 (18), p.5795-5800 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | Boccoli, G Masciulli, R Ruggeri, E M Carlini, P Giannella, G Montesoro, E Mastroberardino, G Isacchi, G Testa, U Calabresi, F |
| description | Serum concentration kinetics of gamma-interferon (IFN-gamma), neopterin, 2'-5' A synthetase and tumor necrosis factor alpha were determined in five cancer patients undergoing adoptive immunotherapy with high-dose interleukin 2 (IL-2) bolus infusion and lymphokine-activated killer cells according to the National Cancer Institute, NIH protocol. In all cases a significant increase of these markers was observed after IL-2 treatment. This suggests that the antitumor effect of high-dose IL-2 bolus administration may be in part mediated by activation of a cascade of endogenous cytokines including IFN-gamma and tumor necrosis factor alpha. After IL-2 bolus injection, the kinetics of neopterin was similar but delayed when compared to that of IFN-gamma: this suggests that macrophages, the specific source of neopterin, become activated by IFN-gamma following IL-2-mediated lymphocyte induction, thus implying a possible role for macrophages in the antitumor effects mediated by IL-2 and lymphokine-activated killer cells. |
| format | Article |
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In all cases a significant increase of these markers was observed after IL-2 treatment. This suggests that the antitumor effect of high-dose IL-2 bolus administration may be in part mediated by activation of a cascade of endogenous cytokines including IFN-gamma and tumor necrosis factor alpha. 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In all cases a significant increase of these markers was observed after IL-2 treatment. This suggests that the antitumor effect of high-dose IL-2 bolus administration may be in part mediated by activation of a cascade of endogenous cytokines including IFN-gamma and tumor necrosis factor alpha. After IL-2 bolus injection, the kinetics of neopterin was similar but delayed when compared to that of IFN-gamma: this suggests that macrophages, the specific source of neopterin, become activated by IFN-gamma following IL-2-mediated lymphocyte induction, thus implying a possible role for macrophages in the antitumor effects mediated by IL-2 and lymphokine-activated killer cells.</description><subject>2',5'-Oligoadenylate Synthetase - blood</subject><subject>Biopterins - analogs & derivatives</subject><subject>Biopterins - blood</subject><subject>Cells, Cultured</subject><subject>Humans</subject><subject>Immunization, Passive</subject><subject>Interferon-gamma - blood</subject><subject>Interleukin-2 - therapeutic use</subject><subject>Killer Cells, Lymphokine-Activated - immunology</subject><subject>Macrophage Activation</subject><subject>Monocytes - drug effects</subject><subject>Monocytes - immunology</subject><subject>Neoplasms - therapy</subject><subject>Neopterin</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><issn>0008-5472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLtOxDAQRVOAlmXhE5Bc0UWyEzuO6VYrXtJKNFBHfkw2htgOsQPaH-C7scT2VDN37tEp5qxYY4zbklFeXRSXMb7nyAhmq2JVEdLSiqyLn60JU7JfgKxziw9pgFlORxR6NCxOeqSl1zDfoVwgfUzhw_q8yKilASS9QS74kIscdPbIZINHfRjH8G39AQ32MJQmxOz3CeYRlixAFVJhXCJKM8jkwKer4ryXY4Tr09wUbw_3r7uncv_y-Lzb7suh4iSVtaha1jRCaSWx5qwlRmmQjJpGgjIUYxCmFoZTxjkxON9Vq_pec2pYVct6U9z-eac5fC4QU-ds1DCO0kNYYseF4JQy8S9IWMsFoU0Gb07gohyYbpqtk_OxO324_gWaZnnr</recordid><startdate>19900915</startdate><enddate>19900915</enddate><creator>Boccoli, G</creator><creator>Masciulli, R</creator><creator>Ruggeri, E M</creator><creator>Carlini, P</creator><creator>Giannella, G</creator><creator>Montesoro, E</creator><creator>Mastroberardino, G</creator><creator>Isacchi, G</creator><creator>Testa, U</creator><creator>Calabresi, F</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19900915</creationdate><title>Adoptive immunotherapy of human cancer: the cytokine cascade and monocyte activation following high-dose interleukin 2 bolus treatment</title><author>Boccoli, G ; 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In all cases a significant increase of these markers was observed after IL-2 treatment. This suggests that the antitumor effect of high-dose IL-2 bolus administration may be in part mediated by activation of a cascade of endogenous cytokines including IFN-gamma and tumor necrosis factor alpha. After IL-2 bolus injection, the kinetics of neopterin was similar but delayed when compared to that of IFN-gamma: this suggests that macrophages, the specific source of neopterin, become activated by IFN-gamma following IL-2-mediated lymphocyte induction, thus implying a possible role for macrophages in the antitumor effects mediated by IL-2 and lymphokine-activated killer cells.</abstract><cop>United States</cop><pmid>2118421</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Cancer research (Chicago, Ill.), 1990-09, Vol.50 (18), p.5795-5800 |
| issn | 0008-5472 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research |
| subjects | 2',5'-Oligoadenylate Synthetase - blood Biopterins - analogs & derivatives Biopterins - blood Cells, Cultured Humans Immunization, Passive Interferon-gamma - blood Interleukin-2 - therapeutic use Killer Cells, Lymphokine-Activated - immunology Macrophage Activation Monocytes - drug effects Monocytes - immunology Neoplasms - therapy Neopterin Tumor Necrosis Factor-alpha - analysis |
| title | Adoptive immunotherapy of human cancer: the cytokine cascade and monocyte activation following high-dose interleukin 2 bolus treatment |
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