Inhibition of Influenza Virus Sialidase and Anti-influenza Virus Activity by Plant Flavonoids
Flavonoids (103 species) were tested for inhibitory activity against influenza virus sialidase using sodium p-nitrophenyl-N-acetyl-α-D-neuraminate as substrate. 5, 7, 4'-Trihydroxy-8-methoxyflavone from the root of Scutellaria baicalensis showed the most potent activity (IC50, 55μM), and this f...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1990/05/25, Vol.38(5), pp.1329-1332 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | NAGAI, Takayuki MIYAICHI, Yukinori TOMIMORI, Tsuyoshi SUZUKI, Yujiro YAMADA, Haruki |
| description | Flavonoids (103 species) were tested for inhibitory activity against influenza virus sialidase using sodium p-nitrophenyl-N-acetyl-α-D-neuraminate as substrate. 5, 7, 4'-Trihydroxy-8-methoxyflavone from the root of Scutellaria baicalensis showed the most potent activity (IC50, 55μM), and this flavone appeared to be a non-competitive inhibitor of the enzyme, Whereas, negligible or weak inhibitory activities were observed for mouse liver sialidase, β-galactosidase and α-mannosidase as tested. This flavone also inhibited the infection by influenza virus A/PR/8/34 of Madin-Darby canine kidney cells, and replication of the virus in the allantoic sack of embryonated egg. These results suggest that flavone, which has potent influenza virus sialidase inhibitory activity, may have anti-influenza virus activity. |
| doi_str_mv | 10.1248/cpb.38.1329 |
| format | Article |
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This flavone also inhibited the infection by influenza virus A/PR/8/34 of Madin-Darby canine kidney cells, and replication of the virus in the allantoic sack of embryonated egg. These results suggest that flavone, which has potent influenza virus sialidase inhibitory activity, may have anti-influenza virus activity.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.38.1329</identifier><identifier>PMID: 2393958</identifier><identifier>CODEN: CPBTAL</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Chick Embryo ; Chickens ; Dogs ; Exact sciences and technology ; flavonoid ; Flavonoids - isolation & purification ; Flavonoids - pharmacology ; Hemagglutination Tests ; In Vitro Techniques ; infection ; Influenza A virus - drug effects ; Influenza A virus - enzymology ; influenza virus ; inhibitor ; Mathematical analysis ; Mathematics ; neuraminidase ; Neuraminidase - antagonists & inhibitors ; Potential theory ; Sciences and techniques of general use ; Scutellaria baicalensis ; Sialidase</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1990/05/25, Vol.38(5), pp.1329-1332</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1991 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1990</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5829-15b799b9c0c2da1c3cdd3ad3ffec5a3dc69dc69b7378c9500e72f8d3ce836cac3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19519803$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2393958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NAGAI, Takayuki</creatorcontrib><creatorcontrib>MIYAICHI, Yukinori</creatorcontrib><creatorcontrib>TOMIMORI, Tsuyoshi</creatorcontrib><creatorcontrib>SUZUKI, Yujiro</creatorcontrib><creatorcontrib>YAMADA, Haruki</creatorcontrib><title>Inhibition of Influenza Virus Sialidase and Anti-influenza Virus Activity by Plant Flavonoids</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>Flavonoids (103 species) were tested for inhibitory activity against influenza virus sialidase using sodium p-nitrophenyl-N-acetyl-α-D-neuraminate as substrate. 5, 7, 4'-Trihydroxy-8-methoxyflavone from the root of Scutellaria baicalensis showed the most potent activity (IC50, 55μM), and this flavone appeared to be a non-competitive inhibitor of the enzyme, Whereas, negligible or weak inhibitory activities were observed for mouse liver sialidase, β-galactosidase and α-mannosidase as tested. This flavone also inhibited the infection by influenza virus A/PR/8/34 of Madin-Darby canine kidney cells, and replication of the virus in the allantoic sack of embryonated egg. These results suggest that flavone, which has potent influenza virus sialidase inhibitory activity, may have anti-influenza virus activity.</description><subject>Animals</subject><subject>Chick Embryo</subject><subject>Chickens</subject><subject>Dogs</subject><subject>Exact sciences and technology</subject><subject>flavonoid</subject><subject>Flavonoids - isolation & purification</subject><subject>Flavonoids - pharmacology</subject><subject>Hemagglutination Tests</subject><subject>In Vitro Techniques</subject><subject>infection</subject><subject>Influenza A virus - drug effects</subject><subject>Influenza A virus - enzymology</subject><subject>influenza virus</subject><subject>inhibitor</subject><subject>Mathematical analysis</subject><subject>Mathematics</subject><subject>neuraminidase</subject><subject>Neuraminidase - antagonists & inhibitors</subject><subject>Potential theory</subject><subject>Sciences and techniques of general use</subject><subject>Scutellaria baicalensis</subject><subject>Sialidase</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rGzEYhEVpSJ20p54LgtJcyrqSXssrHU3atIZACv24FfGupG1k1lpX2g04v75abBLIJQdJh3mY0TCEvOVszsVCfbK7Zg5qzkHoF2TGYVFXUgh4SWaMMV0JWMIrcpbzhjEhWQ2n5FSABi3VjPxZx9vQhCH0kfYtXce2G328R_o7pDHTHwG74DB7itHRVRxCFZ4gKzuEuzDsabOn3zuMA73q8K6PfXD5NTlpscv-zfE9J7-uvvy8_FZd33xdX66uKyuV0BWXTa11oy2zwiG3YJ0DdNC23koEZ5d6Ok0NtbJaMuZr0SoH1itYWrRwTi4OvrvU_xt9Hsw2ZOu78h3fj9kU97r0hWdBLpViCngB3z8BN_2YYilh-GLJBCyYFIX6eKBs6nNOvjW7FLaY9oYzM21jyjYGlJm2KfS7o-fYbL17YI9jFP3DUcdssWsTRhvyo6WWXCs2lfh84DZ5wL_-AcA0BNv5KbOwasqVh2uKf5RvMRkf4T8qbK80</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>NAGAI, Takayuki</creator><creator>MIYAICHI, Yukinori</creator><creator>TOMIMORI, Tsuyoshi</creator><creator>SUZUKI, Yujiro</creator><creator>YAMADA, Haruki</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Inhibition of Influenza Virus Sialidase and Anti-influenza Virus Activity by Plant Flavonoids</title><author>NAGAI, Takayuki ; MIYAICHI, Yukinori ; TOMIMORI, Tsuyoshi ; SUZUKI, Yujiro ; YAMADA, Haruki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5829-15b799b9c0c2da1c3cdd3ad3ffec5a3dc69dc69b7378c9500e72f8d3ce836cac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Chick Embryo</topic><topic>Chickens</topic><topic>Dogs</topic><topic>Exact sciences and technology</topic><topic>flavonoid</topic><topic>Flavonoids - isolation & purification</topic><topic>Flavonoids - pharmacology</topic><topic>Hemagglutination Tests</topic><topic>In Vitro Techniques</topic><topic>infection</topic><topic>Influenza A virus - drug effects</topic><topic>Influenza A virus - enzymology</topic><topic>influenza virus</topic><topic>inhibitor</topic><topic>Mathematical analysis</topic><topic>Mathematics</topic><topic>neuraminidase</topic><topic>Neuraminidase - antagonists & inhibitors</topic><topic>Potential theory</topic><topic>Sciences and techniques of general use</topic><topic>Scutellaria baicalensis</topic><topic>Sialidase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NAGAI, Takayuki</creatorcontrib><creatorcontrib>MIYAICHI, Yukinori</creatorcontrib><creatorcontrib>TOMIMORI, Tsuyoshi</creatorcontrib><creatorcontrib>SUZUKI, Yujiro</creatorcontrib><creatorcontrib>YAMADA, Haruki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NAGAI, Takayuki</au><au>MIYAICHI, Yukinori</au><au>TOMIMORI, Tsuyoshi</au><au>SUZUKI, Yujiro</au><au>YAMADA, Haruki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of Influenza Virus Sialidase and Anti-influenza Virus Activity by Plant Flavonoids</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1990</date><risdate>1990</risdate><volume>38</volume><issue>5</issue><spage>1329</spage><epage>1332</epage><pages>1329-1332</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>Flavonoids (103 species) were tested for inhibitory activity against influenza virus sialidase using sodium p-nitrophenyl-N-acetyl-α-D-neuraminate as substrate. 5, 7, 4'-Trihydroxy-8-methoxyflavone from the root of Scutellaria baicalensis showed the most potent activity (IC50, 55μM), and this flavone appeared to be a non-competitive inhibitor of the enzyme, Whereas, negligible or weak inhibitory activities were observed for mouse liver sialidase, β-galactosidase and α-mannosidase as tested. This flavone also inhibited the infection by influenza virus A/PR/8/34 of Madin-Darby canine kidney cells, and replication of the virus in the allantoic sack of embryonated egg. These results suggest that flavone, which has potent influenza virus sialidase inhibitory activity, may have anti-influenza virus activity.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>2393958</pmid><doi>10.1248/cpb.38.1329</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Chemical and Pharmaceutical Bulletin, 1990/05/25, Vol.38(5), pp.1329-1332 |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Chick Embryo Chickens Dogs Exact sciences and technology flavonoid Flavonoids - isolation & purification Flavonoids - pharmacology Hemagglutination Tests In Vitro Techniques infection Influenza A virus - drug effects Influenza A virus - enzymology influenza virus inhibitor Mathematical analysis Mathematics neuraminidase Neuraminidase - antagonists & inhibitors Potential theory Sciences and techniques of general use Scutellaria baicalensis Sialidase |
| title | Inhibition of Influenza Virus Sialidase and Anti-influenza Virus Activity by Plant Flavonoids |
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