The pharmacokinetic change of lidocaine by catecholamines using isolated perfused rat liver (IPRL)

We hypothesized that changes in the pharmacokinetics of lidocaine might reveal changes in portal circulation induced by catecholamines. Isolated perfused rat liver (IPRL) was selected as an experimental model, since experimental conditions in this model could be regulated. The liver was perfused wit...

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Veröffentlicht in:	Life sciences (1973) 1998, Vol.62 (26), p.2399-2405
Hauptverfasser:	Shimadzu, Kazuhisa, Nishi, Shinichi, Kariya, Nobutaka, Yamamoto, Isao, Asada, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Local - pharmacokinetics Animals Blood Pressure - drug effects Blood Pressure - physiology catecholamine Catecholamines - pharmacology In Vitro Techniques lidocaine Lidocaine - pharmacokinetics Liver - drug effects Liver - metabolism Male Models, Biological Oxygen Consumption - drug effects rat Rats Rats, Sprague-Dawley two-compartment model
Online-Zugang:	Volltext
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