Overexpression of Human Superoxide Dismutase Inhibits Oxidation of Low-Density Lipoprotein by Endothelial Cells

Oxidation of LDL in the subendothelial space has been proposed to play a key role in atherosclerosis. Endothelial cells produce superoxide anions (O (2) sup [center dot] -) and oxidize LDL in vitro; however, the role of O2 sup [center dot] - in endothelial cell-induced LDL oxidation is unclear. Incu...

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Veröffentlicht in:	Circulation research 1998-06, Vol.82 (12), p.1289-1297
Hauptverfasser:	Fang, Xiang, Weintraub, Neal L, Rios, C. David, Chappell, David A, Zwacka, Ralf M, Engelhardt, John F, Oberley, Larry W, Yan, Tao, Heistad, Donald D, Spector, Arthur A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Animals Biological and medical sciences Cattle Cells, Cultured Endothelium, Vascular - metabolism Fundamental and applied biological sciences. Psychology Gene expression Genetic Vectors Humans Lipoproteins, LDL - metabolism Molecular and cellular biology Molecular genetics Oxidation-Reduction Oxygen - metabolism Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Transfection
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