31P NMR study of the interactions between oligodeoxynucleotides containing (6-4) photoproduct and Fab fragments of monoclonal antibodies specific for (6-4) photoproduct

A 31P nuclear magnetic resonance (NMR) study of the interactions between oligonucleotides containing the (6-4) photoproduct and the Fab fragments of monoclonal antibodies (64M3 and 64M5) recognizing the (6-4) photoproduct is reported. The 31P chemical shift data indicate that backbone conformation o...

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Veröffentlicht in:	FEBS letters 1998-06, Vol.429 (2), p.157-161
Hauptverfasser:	Torizawa, Takuya, Kato, Koichi, Kimura, Yoshiko, Asada, Takako, Kobayashi, Hiroyuki, Komatsu, Yasuo, Morioka, Hiroshi, Nikaido, Osamu, Ohtsuka, Eiko, Shimada, Ichio
Format:	Artikel
Sprache:	eng
Schlagworte:	(6-4) Photoproduct 2D, two-dimensional 31P nuclear magnetic resonance Antibodies, Monoclonal - immunology Antibody Antigen-Antibody Reactions d(T[6-4]T), pyrimidine (6-4) pyrimidone photoproduct of thymidylyl-(3′→5′)-thymidine DNA Adducts DNA damage DQF-COSY, double-quantum filtered correlated spectroscopy EDTA, ethylenediaminetetraacetic acid Epitope Mapping Fab HMBC, heteronuclear multiple-bond correlation HPLC, high-performance liquid chromatography HSQC, heteronuclear single-quantum correlation Immunoglobulin Fab Fragments - immunology NOE, nuclear Overhauser effect Nuclear Magnetic Resonance, Biomolecular - methods Nucleic Acid Conformation Phosphorus Isotopes Protein-nucleic acid interaction Pyrimidine Dimers - chemistry Pyrimidine Dimers - immunology ROESY, rotating frame Overhauser effect spectroscopy SPR, surface plasmon resonance TOCSY, total correlation spectroscopy
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